Low serum levels of 25-hydroxyvitamin D (25-OHD) among psychiatric out-patients in Sweden: Relations with season, age, ethnic origin and psychiatric diagnosis

Humble, Mats B.; Gustafsson, Sven A.; Bejerot, Susanne

doi:10.1016/j.jsbmb.2010.03.013

Cited by 111 publications

(82 citation statements)

References 31 publications

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“…In fact, Lebanon is located at appropriate latitudes (33° 35'N) [38] for the synthesis of vitamin D [39] and thus, higher levels of total vitamin D would be expected [39]. Furthermore, our results indicated that patients with schizophrenia, as well as the healthy ones, had a vitamin D deficiency, similar to previous studies [2,4,36,37,40,41]. Other studies conducted in Lebanon had shown a hypovitaminosis D in the healthy population [35,[42][43][44][45].…”

Section: Discussionsupporting

confidence: 87%

Vitamin D Levels in Lebanese Patients with Schizophrenia: A Case-Control Study

Azar¹

2017

Ann Nutr Disord & Ther

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Objectives: To compare the vitamin D status in schizophrenics to that of healthy controls; secondary objectives were to assess the correlation between severe vitamin D deficiency and the severity of schizophrenia symptoms and to evaluate the potential factors influencing this status. Methods:A case-control study, conducted between March and July 2016, recruited 100 patients with schizophrenia and 100 controls with no known psychiatric disorders and matched for age and sex.Results: Schizophrenic patients had a more severe vitamin D deficiency compared to healthy controls (9% vs. 3%). Vitamin D insufficiency was found in 28% of schizophrenic patients compared to 37% in healthy controls (p=0.053). BCRS and MRSS scales were significantly associated with a more severe vitamin D deficiency (p=0.006). We couldn't detect any association between the total PANSS score and its three subscales with vitamin D deficiency (p>0.05). Lebanon has a high prevalence of 25(OH)-D deficiency in adults and older adults [23,24] however, data regarding vitamin D levels in psychiatric patients is still lacking. Therefore, the primary objective of this study was to compare the vitamin D status in schizophrenics to that of healthy controls; secondary objectives were to assess the

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Section: Discussionsupporting

confidence: 87%

Vitamin D Levels in Lebanese Patients with Schizophrenia: A Case-Control Study

Azar¹

2017

Ann Nutr Disord & Ther

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“…Infant cohort studies have revealed elevated risk for schizophrenia in infants with deficient vitamin D (McGrath et al, 2010) and reduced risk in those who had received supplementation (McGrath et al, 2004). Deficient serum levels of vitamin D have been observed in patients with first episode psychosis (Graham et al, 2014) as well as in patients with chronic schizophrenia (Humble et al, 2010). A recent meta-analysis on the relationship between vitamin D and psychosis reported a moderately significant reduction in serum levels of vitamin D in schizophrenia patients compared with healthy controls and a trend for lower levels compared with other psychoses (Belvederi Murri et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Serum vitamin D and hippocampal gray matter volume in schizophrenia

Shivakumar

Kalmady

Amaresha

et al. 2015

Psychiatry Research: Neuroimaging

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“…(4) reported decreased 25(OH)D in patients with autism and schizophrenia but not in the studied group of patients with ADHD. Also, no studies or case reports are found for ADHD and rickets (a childhood bone disorder caused by vitamin D deficiency).When looking at CDC data on vitamin D deficiency and inadequacy[assessed with serum 25(OH)D], there was a slight increase from 1988 to 2002, but no change between 2001 and 2006 (5), whereas the same CDC reported a significant increase in self-reported ADHD PREV from 7.8% in 2003 to 9.5% in 2007 (2), suggesting these trends do not match.…”

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confidence: 65%