Low serum prolactin levels in native women at high altitude

Gonzales, Gustavo F.; Carrillo, Carlos

doi:10.1016/0020-7292(93)90325-q

Cited by 10 publications

(4 citation statements)

References 9 publications

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“…Prolactin concentration in women born and living at 4,340 m, compared to that of women at sea level, is diminished in chronic hypoxia [ 94 ]. Increased fertility and decreased frequency of menstrual disturbances have also been observed among high-altitude women compared with women living at sea level [ 94 ].…”

Section: Other Hormones Prolactinmentioning

confidence: 96%

Endocrine Function

Richalet

2013

High Altitude

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Adaptation to a stressful environment such as altitude hypoxia will affect most hormonal systems. Stress hormones (cortisol, epinephrine, norepinephrine, prolactin) are stimulated in acute hypoxia but adrenergic system is down-regulated in prolonged hypoxia. Thyroid hormone is increased in hypoxia, with no change in TSH. Parathromone is stimulated and parathromone receptors desensitized with prolonged exposure. Leptin is increased and ghrelin decreased with exposure to hypoxia. Growth hormone is poorly affected by acute hypoxia and exercise-induced GH response is potentiated by acute hypoxia. LH and FSH decrease with acute hypoxia. The hypophyseal response to hypothalamic factors is not substantially modifi ed in altitude hypoxia. The possible role of hypoxiainducible factors in the regulation of hormones at high altitude remains to be explored.

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Section: Other Hormones Prolactinmentioning

confidence: 96%

Endocrine Function

Richalet

2013

High Altitude

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“…Las mujeres en las alturas de Perú se caracterizan por conservar su capacidad reproductiva (5) ; sin embargo, existen varios parámetros reproductivos que difieren con las mujeres residentes a nivel del mar: la menarquia es más tardía (6) y la menopausia es más temprana (7) . En mujeres en edad reproductiva, los niveles plasmáticos de estradiol, progesterona (8) y prolactina (9) son menores en la altura que a nivel del mar, mientras que sucede lo contrario al controlar los niveles séricos de la hormona folículo estimulante durante la perimenopausia (10) . La presente revisión intenta mostrar el impacto que tiene la exposición a la altura en el curso de un embarazo.…”

Section: Impacto De La Altura En El Embarazo Y En El Producto De La Gunclassified

Impacto de la altura en el embarazo y en el producto de la gestación

Gonzáles¹

2012

Rev Peru Med Exp Salud Publica

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This review describes adverse outcomes in pregnancy after brief, intermittent, or permanent residence at high altitudes. Review of literature shows that congenital malformations rates are higher at high altitudes. Additionally, rates of stillbirths, small size for gestational age, and preeclampsia are increased in populations living at high altitudes and are associated with high maternal hemoglobin levels (>14.5 g/dl). In conclusion, a pregnant woman exposed briefly, intermittently, or permanently to high altitudes results in increased risk of adverse outcomes when compared to pregnancies observed at sea level.

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“…Als ursächlicher Faktor für diese hormonellen Veränderungen wurde ein unter denselben Bedingungen festgestellter Anstieg des Serum-Prolaktins postuliert. Bei weiblichen Hochlandbewohnern wurde allerdings im Gegensatz dazu ein durchschnittlich niedrigerer Serum-Prolaktinspiegel, als bei vergleichbaren Flachlandbewohnerinnen beschrieben, und zwar sowohl bei Schwangeren als auch bei nicht Schwangeren [9]. Auch war die Inzidenz prolaktininduzierter Zyklusunregelmäßigkeiten bei Hochlandbewohnerinnen signifikant niedriger als bei Flachlandbewohnerinnen.…”

Section: Körperreife Und Gonadenunclassified

The effects of chronic hypobaric conditions

Dimai

2005

Wien Med Wochenschr

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Many studies have concentrated on investigating the effects of short and medium term hypobaric conditions in people living at low altitudes. In contrast, only little is known about long term or genetic adaptations to chronic hypobaric conditions in people living at high altitudes. A small number of phenotypic characteristics have been defined in these people so far, comprising hormonal functions, oxygen saturation of hemoglobin, skeletal growth, muscular morphology and function, cardiovascular functions, and fluid and electrolyte changes. Several of these characteristics have been attributed to genetic adaptations. However, so far, no specific genes coding for any of the specific phenotypes found in high altitude dwellers have been detected.

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Low serum prolactin levels in native women at high altitude

Abstract: It is concluded that menstrual abnormalities associated with hyperprolactinemia is a rare condition at high altitude. The low serum prolactin level observed at high altitude could be due to a high dopaminergic activity.

Cited by 10 publications

References 9 publications

Endocrine Function

Endocrine Function

Impacto de la altura en el embarazo y en el producto de la gestación

The effects of chronic hypobaric conditions

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