Low Serum Vitamin D Levels in Egyptian Adults With Chronic Primary Immune Thrombocytopenia: A Single Center Study.

Abstract

Objectives:Immune thrombocytopenia (ITP) is a disorder characterized by immune-mediated accelerated platelet destruction and suppressed platelet production. Low vitamin D levels have been found in several autoimmune diseases, such as rheumatoid arthritis, SLE. The mechanisms underlying the link between vitamin D with autoimmunity are not completely understood. No currently available studies about vitamin D status in primary ITP patients. Aim: To evaluate vitamin D levels in patients with primary chronic ITP and compare these levels with normal control subjects and patients with thrombocytopenia due to other non-immune causes Methods: The study included 80 adult subjects, 40 ITP patients (They were segregated into 20 responders and 20 non-responders), 20 cases of thrombocytopenia due to non ITP causes and 20 healthy control subjects. Measurement of serum 25monohydroxyvitamin D was done with ELISA. Results: Vitamin D levels were significantly lower in patients with ITP (range=2-40ng/ml; mean±SD=17.29±10.96 ng/ml) and thrombocytopenia due to non-ITP causes (range=10-40ng/ml; mean±SD=21.05±8.31 ng/ml) in comparison to normal healthy controls (range = 10-65 ng/ml; mean±SD=36.70±16

Low serum vitamin D levels in Iranians with immune thrombocytopenia: A single-center study

“…In the present study, we have found a significantly lower mean levels of vitamin D among ITP cases compared to healthy control group, (18.85±10.87 ng/ml) vs (32-100 ng/ml) ( 14) respectively with p-value <0.001. These findings were in accordance with the findings of Soliman et al (8) and Mu et al (15). Our study has shown that the blood level of vitamin D in chronic ITP was higher than acute ITP although not statistically However, our study have some limitations.…”

“…The mean age of ITP patients in our study was 39.90 ± 16.11 years, this was higher than that described by Cines and Bussel (10) In the present study, we did not find a significant correlation between vitamin D levels and age, sex or disease duration in ITP patients. This finding is in line with the results of a study by Soliman et al (8). Also other studies did not find a significant correlation between vitamin D level and age or disease duration in SLE (12) and rheumatoid arthritis (13) patients.…”

“…The present study included 140 ITP patients (71 females and 69 males), 87 patients with acute and 53 with chronic thrombocytopenia. The proportion of females to males was nearly similar, but according to the findings of Schoonen et al (7) and Soliman et al (8), ITP in female patients was higher than male patients. But in a study in Iran this ration was equal (9).…”