Low structural diversity of the O-polysaccharides of Photorhabdus asymbiotica subspp. asymbiotica and australis and their similarity to the O-polysaccharides of taxonomically remote bacteria including Francisella tularensis

Kondakova, Anna N.; Kirsheva, Nadezhda A.; Shashkov, Alexander S.; Shaikhutdinova, Rima Z.; Arabtsky, Nikolay P.; Ivanov, Sergey A.; Anisimov, Andrey P.; Knirel, Yuriy A.

doi:10.1016/j.carres.2011.05.019

Cited by 11 publications

(2 citation statements)

References 19 publications

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“…In the O-antigens of S. disenteriae type 7 and of the E. coli O121 and in the O-antigen of the emerging human pathogen Photorhabdus asymbiotica, the amino group of Vio can be acylated by an acetyl or an acetyl-glycyl group (16,18), whereas F. tularensis LPS O-antigen contains a formyl group (18). In B. anthracis spores, Vio is further modified to obtain 2-O-methy-L-4-(3-hydroxy-3-methyl butanamido)-4,6-dideoxy-D-Glc, which is named anthrose (17).…”

Section: Discussionmentioning

confidence: 99%

“…Vio is found in several bacterial glycans, such as the LPS O-antigens of Shigella disenteriae type 7 and of the Shiga toxin-producing Escherichia coli O121 (16), the fiber-associated pentasaccharide of Bacillus anthracis exosporium (17), the O-polysaccharide of Francisella tularensis and of the emerging pathogen Photorabdus asymbyotica (18), the glycans of Pseudomonas syringae flagellin (19), and the capsular polysaccharides of several marine bacteria belonging to the genus Pseudoalteromonas and Shewanella (20 -21). We also analyzed the sugar composition of Mimivirus by GC-MS and were able to demonstrate that, together with Vio, major components of the viral glycans are Rha, Glc, and (N-acetyl)-glucosamine (GlcN(Ac)).…”

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Giant DNA Virus Mimivirus Encodes Pathway for Biosynthesis of Unusual Sugar 4-Amino-4,6-dideoxy-d-glucose (Viosamine)

Piacente

Marin

Molinaro

et al. 2012

Journal of Biological Chemistry

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Background: Mimivirus is highly glycosylated; however, nothing is known about its glycan composition and structure. Results: We identified a Mimivirus UDP-viosamine synthetic pathway, and we determined the sugar composition of viral fibers. Conclusion: Our data give further support to the presence of a Mimivirus-encoded glycosylation machinery. Significance: These results contribute to shed light on the origin of viral glycosylation systems.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Giant DNA Virus Mimivirus Encodes Pathway for Biosynthesis of Unusual Sugar 4-Amino-4,6-dideoxy-d-glucose (Viosamine)

Piacente

Marin

Molinaro

et al. 2012

Journal of Biological Chemistry

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Photorhabdus asymbiotica as an Insect and Human Pathogen

Hapeshi

Waterfield

2016

Current Topics in Microbiology and Immunology

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Photorhabdus asymbiotica is a species of bacterium that is pathogenic to humans whilst retaining the ability to infect insect hosts. Currently, there are two recognised subspecies, P. asymbiotica subsp. asymbiotica and P. asymbiotica subsp. australis with strains isolated from various locations in the USA, Australia, Thailand, Nepal and Europe. Like other species of Photorhabdus, P. asymbiotica subsp. australis was shown to form a symbiotic relationship with a Heterorhabditis nematode. In contrast to most strains of Photorhabdus luminescens, P. asymbiotica can grow at 37 °C and this is a defining factor in its ability to cause human disease. Insights into other adaptations it has undergone that have enabled host switching to occur have come from whole genome sequencing and transcriptomic studies. P. asymbiotica has a smaller genome compared to P. luminenscens with a lower diversity of insecticidal toxins. However, it has acquired plasmids and several pathogenicity islands in its genome. These encode genes with similarity to effectors or systems found in other known human pathogens such as Salmonella and Yersinia and are therefore likely to contribute to human pathogenicity. Of crucial importance to virulence is the fact that P. asymbiotica undergoes a large metabolic shift at the human host temperature.

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Structure of the O-polysaccharide of Photorhabdus luminescens subsp. laumondii containing d-glycero-d-manno-heptose and 3,6-dideoxy-3-formamido-d-glucose

Kondakova¹,

Kirsheva²,

Shashkov³

et al. 2012

Carbohydrate Research

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Low structural diversity of the O-polysaccharides of Photorhabdus asymbiotica subspp. asymbiotica and australis and their similarity to the O-polysaccharides of taxonomically remote bacteria including Francisella tularensis

Cited by 11 publications

References 19 publications

Giant DNA Virus Mimivirus Encodes Pathway for Biosynthesis of Unusual Sugar 4-Amino-4,6-dideoxy-d-glucose (Viosamine)

Giant DNA Virus Mimivirus Encodes Pathway for Biosynthesis of Unusual Sugar 4-Amino-4,6-dideoxy-d-glucose (Viosamine)

Photorhabdus asymbiotica as an Insect and Human Pathogen

Structure of the O-polysaccharide of Photorhabdus luminescens subsp. laumondii containing d-glycero-d-manno-heptose and 3,6-dideoxy-3-formamido-d-glucose

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