Low temperature plasma-assisted chemical vapour deposition of amorphous carbon films for biomedical-polymeric substrates

McColl, I.R.; Grant, David M.; Green, S.M.; Wood, J. V.; Parker, Terry L.; Parker, Katherine L.; Goruppa, A.; Braithwaite, Nicholas

doi:10.1016/0925-9635(94)90035-3

Cited by 45 publications

(21 citation statements)

References 4 publications

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“…The excellent biocompatibility of DLC films in orthopedic and cardiovascular applications has been demonstrated [166][167][168]. DLC coatings have been deposited on biomedical implants using various CVD methods [169][170][171][172]. Ianno et al reported the deposition of DLC on Ti-6Al-4V by PECVD intended for use in hip and knee prostheses.…”

Section: Chemical Vapor Depositionmentioning

confidence: 99%

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

Liu

Chu

Ding

2004

Materials Science and Engineering: R: Reports

3,077

1,477

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Titanium and titanium alloys are widely used in biomedical devices and components, especially as hard tissue replacements as well as in cardiac and cardiovascular applications, because of their desirable properties, such as relatively low modulus, good fatigue strength, formability, machinability, corrosion resistance, and biocompatibility. However, titanium and its alloys cannot meet all of the clinical requirements. Therefore, in order to improve the biological, chemical, and mechanical properties, surface modification is often performed. This article reviews the various surface modification technologies pertaining to titanium and titanium alloys including mechanical treatment, thermal spraying, sol-gel, chemical and electrochemical treatment, and ion implantation from the perspective of biomedical engineering. Recent work has shown that the wear resistance, corrosion resistance, and biological properties of titanium and titanium alloys can be improved selectively using the appropriate surface treatment techniques while the desirable bulk attributes of the materials are retained. The proper surface treatment expands the use of titanium and titanium alloys in the biomedical fields. Some of the recent applications are also discussed in this paper. #

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Section: Chemical Vapor Depositionmentioning

confidence: 99%

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

Liu

Chu

Ding

2004

Materials Science and Engineering: R: Reports

3,077

1,477

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“…DLC coatings are widely used as scratch-resistant coatings for civilian and military optics, 5 and as hard, wear-resistant coatings for machine tools 6 and surgical instruments. 7 An increase in surface roughness and surface energy has been shown to increase the rate of bacterial colonization and biofilm formation.…”

Section: Introductionmentioning

confidence: 99%

Modulation of the soft tissue reactions to percutaneous orthopaedic implants

et al. 2006

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To evaluate soft tissue reactions and biofilm formation on percutaneous external fixator screws coated with diamond-like carbon (DLC) and hydroxyapatite (HA) coatings on stainless-steel (SS) pins in an ovine loaded osteotomy model, an Orthofix external fixator was used to stabilize a 3-mm tibial midshaft osteotomy with six tapered pins inserted into the right tibia of 32 skeletally mature Friesland ewes. Animals were divided into four groups; SS, fully coated HA, DLC, and HA-coated threads. At 10 weeks, specimens were harvested and the pins were removed en bloc to examine the interfaces between the surface coatings and the tissues. Fully coated HA pins had a significantly higher percentage of dermal contact with the pin surface than HA-coated threads (p ¼ 0.028). The presence of a biofilm was evident on all pin surfaces except DLC-coated pins. Significantly greater numbers of bacteria were present on fully coated HA and plain stainless-steel pins compared with DLC. The surface of DLC-coated pins had a significantly lower number of bacterial colonies compared to SS (p ¼ 0.028) and fully coated HA pins (p ¼ 0.005). Fully coated HA pins have greater dermal attachment to the pin surface than the other pin coatings investigated. DLC-coated pins have the potential to prevent biofilm formation and bacterial colonization that may reduce infection and consequent pin loosening. An external fixator pin that is partially coated with HA to encourage bone and soft tissue integration and with DLC to reduce biofilm formation is advocated. ß

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“…On growing mouse peritoneal macrophages and mouse fibroblast on tissue culture plates treated with a-C:H, no toxicological effects on the cells were observed 57 . a-C:H films grown by RF glow discharge promote cell attachment and normal cell growth rates 58 . Invitro studies of biocompatibility of RF PE-CVD a-C:H coatings showed no cytotoxic effects for mouse macrophages, human fibroblasts and osteoblast-like cells 59 .…”

Section: Biocompatibility Of Diamond-like Carbon Coatingsmentioning

confidence: 99%