Low‐Temperature Printed Hierarchically Porous Induced‐Biomineralization Polyaryletherketone Scaffold for Bone Tissue Engineering

Gao, Xinshuai; Wang, Honghua; Luan, Shifang; Zhou, Guangyuan

doi:10.1002/adhm.202200977

Cited by 15 publications

(14 citation statements)

References 56 publications

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“…[39][40][41] After implantation of the bioactive prosthesis, macrophages are recruited to the implantation area [42] and can secrete various scaffold-induced immunomodulatory chemokines that regulate the associated immune response and bone formation. [42][43][44] Further flow cytometry, ELISA, and immunofluorescence results confirmed that the bioactive prostheses promoted the polarization of macrophages toward the M2 phenotype, which may largely be attributed to polyphenolinduced anti-inflammation. [45] Meanwhile, endogenous stem cells were recruited and homed to defective sites, providing good conditions for mature bone tissues.…”

Section: Discussionmentioning

confidence: 74%

Highly Malleable Personalized Prostheses with Hierarchical Microstructure Boost the Long‐Term Osteointegration in Irregular Craniofacial Reconstruction

Liu,

Tong,

Chen

et al. 2023

Adv Funct Materials

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The desired clinical bone prostheses should achieve satisfactory interface integration and osteoinduction, as well as good surgical convenience. Here, a highly malleable 3D printed prosthesis with compressive strength at 13 MPa is constructed by dopamine, polyvinyl alcohol, and micro‐sized hydroxyapatite (86 wt%) as composite bioinks, which is endowed with good plasticity and can quickly match irregular defects by easily trimming. Spatially decorated collagen and hyaluronan greatly enriched the hierarchical microstructure and biological activity of malleable prosthesis. This prosthesis accelerates the proliferation and osteogenic differentiation of stem cells, regulates M2 polarization of macrophage, and promotes endogenous stem cell recruitment and early angiogenesis. Meanwhile, it significantly reinforces biomineralized deposition and vascularization, reaches full coverage of new bone in the rabbit cranial defect after 15 weeks (Φ = 10 mm), and achieves well osseointegration capacity with interfacial binding strength at 71.2% of the natural skull. This osteoinductive prosthesis provides a new design idea for bone filling.

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Section: Discussionmentioning

confidence: 74%

Highly Malleable Personalized Prostheses with Hierarchical Microstructure Boost the Long‐Term Osteointegration in Irregular Craniofacial Reconstruction

Liu,

Tong,

Chen

et al. 2023

Adv Funct Materials

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“…A compression modulus enhancement of approximately 186% (252.91 MPa) and yield strength enhancement of 43% (4.51 MPa) was observed when only 0.5 wt.% CNTs were added to PEEK/HA. Using a low-temperature 3D printing process, Gao et al [ 28 ] fabricated amorphous PAEK with carboxyl groups (PAEK-COOH) into hierarchically controllable porous scaffolds from the nanoscale to the microscale, with a mechanical strength comparable to that of trabecular bone. The nanoporous surface of the PAEK-COOH scaffold is beneficial in promoting cell adhesion, whereas the carboxyl groups can induce HA mineralization through electrostatic interactions.…”

Section: Mechanical Properties Of Peek In Dental Applicationsmentioning

confidence: 99%

PEEK for Oral Applications: Recent Advances in Mechanical and Adhesive Properties

et al. 2023

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Polyetheretherketone (PEEK) is a thermoplastic material widely used in engineering applications due to its good biomechanical properties and high temperature stability. Compared to traditional metal and ceramic dental materials, PEEK dental implants exhibit less stress shielding, thus better matching the mechanical properties of bone. As a promising medical material, PEEK can be used as implant abutments, removable and fixed prostheses, and maxillofacial prostheses. It can be blended with materials such as fibers and ceramics to improve its mechanical strength for better clinical dental applications. Compared to conventional pressed and CAD/CAM milling fabrication, 3D-printed PEEK exhibits excellent flexural and tensile strength and parameters such as printing temperature and speed can affect its mechanical properties. However, the bioinert nature of PEEK can make adhesive bonding difficult. The bond strength can be improved by roughening or introducing functional groups on the PEEK surface by sandblasting, acid etching, plasma treatment, laser treatment, and adhesive systems. This paper provides a comprehensive overview of the research progress on the mechanical properties of PEEK for dental applications in the context of specific applications, composites, and their preparation processes. In addition, the research on the adhesive properties of PEEK over the past few years is highlighted. Thus, this review aims to build a conceptual and practical toolkit for the study of the mechanical and adhesive properties of PEEK materials. More importantly, it provides a rationale and a general new basis for the application of PEEK in the dental field.

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“…PAEK-COOH was synthesized via nucleophilic substitution poly-condensation reaction (Figure 1a) from phenolphthalin (PPH) and 4, 4'-difluorobenzophenone (DFBP) in dimethyl sulfoxide (DMSO), with potassium carbonate (K 2 CO 3 ) as the catalyst. [22] Analysis by 1 H nuclear magnetic resonance (NMR) and fourier-transformed infrared (FT-IR) spectrum can confirm the presence of ether bonds, carbonyl, and carboxyl groups (Figures S1 and S2, Supporting Information). As reported, EDC can greatly improve the reactivity of carboxyl groups.…”

Section: Synthesis and Characterization Of Compositesmentioning

confidence: 99%

Biofabrication of Poly(aryletherketone)‐Hydroxyapatite Composite Scaffolds via Low‐Temperature Printing

Gao

Wang

Luan

et al. 2023

Adv Materials Technologies

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Inorganic nanoparticles doped into polymer can improve osteogenesis through structural and biological cues. However, the composite implants may be unsatisfactory partly due to the high surface energy of nanoparticles contributing to aggregation and inhomogeneity, resulting in impaired properties. Herein, poly(aryletherketone) bearing carboxyl groups (PAEK‐COOH) is synthesized, and fabricated to composites with nanohydroxyapatite (nHA) via chemical binding. The composites can be formulated to homogeneous and stable bioinks in solution, and the bioinks are fabricated to porous scaffolds via low‐temperature printing, avoiding high‐temperature damage to chemical integrations and bioactive factors. The composite scaffolds present uniform distribution of elements on the surface and mechanical properties are well‐matched with those of trabecular bone. The in vitro experiments show that the addition of nHA is conducive to promote cellular proliferation and induce osteogenic differentiation of cells. Therefore, this work develops a method to prepare uniform composites, and the composite scaffolds have the potential to be used in orthopedic applications.

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Low‐Temperature Printed Hierarchically Porous Induced‐Biomineralization Polyaryletherketone Scaffold for Bone Tissue Engineering

Cited by 15 publications

References 56 publications

Highly Malleable Personalized Prostheses with Hierarchical Microstructure Boost the Long‐Term Osteointegration in Irregular Craniofacial Reconstruction

Highly Malleable Personalized Prostheses with Hierarchical Microstructure Boost the Long‐Term Osteointegration in Irregular Craniofacial Reconstruction

PEEK for Oral Applications: Recent Advances in Mechanical and Adhesive Properties

Biofabrication of Poly(aryletherketone)‐Hydroxyapatite Composite Scaffolds via Low‐Temperature Printing

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