Low-temperature supercritical activation enables high-performance detection of cell-free DNA by all-carbon-nanotube transistor

Ren, Qinqi; Zhang, Yaping; Ma, Shenhui; Wang, Xiaofang; Chang, Kuan‐Chang; Zhang, Yiming; Yin, Feng; Lib, Zigang; Zhang, Min

doi:10.1016/j.carbon.2022.04.068

Cited by 11 publications

(1 citation statement)

References 32 publications

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“…However, defects in the dielectric and channels of CNT-based TFTs inevitably occur and can result in noisy or unreliable output signals. Thus, Ren et al [33] proposed a method for enhancing the performance of TFT-based biosensors by employing a low-temperature supercritical carbon dioxide (SCCO 2 ) fluid activation method. They developed a cell-free DNA sensing platform using an all-CNT-functionalized peptide probe.…”

Section: Electrochemical Sensingmentioning

confidence: 99%

Cancer Targeting and Diagnosis: Recent Trends with Carbon Nanotubes

Singh

Kumar

2022

Nanomaterials

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Cancer belongs to a category of disorders characterized by uncontrolled cell development with the potential to invade other bodily organs, resulting in an estimated 10 million deaths globally in 2020. With advancements in nanotechnology-based systems, biomedical applications of nanomaterials are attracting increasing interest as prospective vehicles for targeted cancer therapy and enhancing treatment results. In this context, carbon nanotubes (CNTs) have recently garnered a great deal of interest in the field of cancer diagnosis and treatment due to various factors such as biocompatibility, thermodynamic properties, and varied functionalization. In the present review, we will discuss recent advancements regarding CNT contributions to cancer diagnosis and therapy. Various sensing strategies like electrochemical, colorimetric, plasmonic, and immunosensing are discussed in detail. In the next section, therapy techniques like photothermal therapy, photodynamic therapy, drug targeting, gene therapy, and immunotherapy are also explained in-depth. The toxicological aspect of CNTs for biomedical application will also be discussed in order to ensure the safe real-life and clinical use of CNTs.

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Section: Electrochemical Sensingmentioning

confidence: 99%

Cancer Targeting and Diagnosis: Recent Trends with Carbon Nanotubes

Singh

Kumar

2022

Nanomaterials

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Ultra‐Flexible Monolithic 3D Complementary Metal‐Oxide‐Semiconductor Electronics

Zhang,

Wang,

Zhu

et al. 2023

Adv Funct Materials

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Flexible electronics based on complementary metal‐oxide‐semiconductor (CMOS) technology have enabled a smart soft world. However, the trade‐off among flexibility, density, and electrical performance has been a long‐lasting unresolved issue. Here, a monolithic three‐dimensional (M3D) CMOS design is proposed to address this problem and realize ultra‐flexible electronics with high electronic‐performance and integration. This design utilizes vertically stacked p‐type carbon nanotube transistors and n‐type indium gallium zinc oxide ones, which share common gates and drains, saving the inter tier vias required in the traditional M3D structure to reduce routing and improve flexibility. With this design, CMOS logic gates, multi‐stage circuits, ring oscillators (ROs) and memory modules, are demonstrated. This design enables circuits to save up to 45% of area compared with their planar counterparts. Particularly, inverters exhibit a record‐high gain of 191, and 55‐stage ROs can operate well even after bending at a 500‐µm radius for 50 cycles, exhibiting the highest flexibility among the reported ones. The ultra‐flexible and high‐integration RO enables a wearable light recorder to collect harmful blue light shining into human eyes by simply attaching the circuits on a contact lens. This integration method provides possibilities for developing complex‐function wearable electronics.

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Multi‐Body Biomarker Entrapment System: An All‐Encompassing Tool for Ultrasensitive Disease Diagnosis and Epidemic Screening

Ren

Jiang

et al. 2023

Advanced Materials

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Ultrasensitive identification of biomarkers in biofluids is essential for precise diagnosis of diseases. For the gold standard approaches, polymerase chain reaction and enzyme‐linked immunosorbent assay, cumbersome operational steps hinder their point‐of‐care applications. Here, w e implement a bionic biomarker entrapment system (BioES), which employs a multi‐body Y‐shaped tetrahedral DNA probe immobilized on carbon nanotube transistors. W e successfully realize clinical identification of endometriosis by detecting an estrogen receptor, ERβ, from the lesion tissue of endometriosis patients and establish a standard diagnosis procedure. The multi‐body Y‐shaped BioES achieves a theoretical limit of detection (LoD) of 6.74 aM and a LoQ of 141 aM in a complex protein milieu. Furthermore, the BioES is optimized into multi‐site recognition module for enhanced binding efficiency, realizing the first identification of monkeypox virus antigen A35R and unamplified detection of circulating tumor DNA of breast cancer in serum. The rigid and compact probe framework with synergy effect enable the BioES to target A35R and DNA with a LoD down to 991 aM and 0.21 aM, respectively. Owing to its versatility for proteins and nucleic acids as well as ease‐of‐manipulation and ultra‐sensitivity, the BioES can be leveraged as an all‐encompassing tool for population‐wide screening of epidemics and clinical disease diagnosis.This article is protected by copyright. All rights reserved

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Low-temperature supercritical activation enables high-performance detection of cell-free DNA by all-carbon-nanotube transistor

Cited by 11 publications

References 32 publications

Cancer Targeting and Diagnosis: Recent Trends with Carbon Nanotubes

Cancer Targeting and Diagnosis: Recent Trends with Carbon Nanotubes

Ultra‐Flexible Monolithic 3D Complementary Metal‐Oxide‐Semiconductor Electronics

Multi‐Body Biomarker Entrapment System: An All‐Encompassing Tool for Ultrasensitive Disease Diagnosis and Epidemic Screening

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