Low-Temperature Synthesis and Antibacterial Activity of Hybrid Systems of Gentamicin Sulfate with Copper and Iron Nanoparticles

Vernaya, O. I.; Шабатин, В. П.; Semenov, A. M.; Шабатина, Т. И.; Melnikov, M.Y.

doi:10.3103/s0027131420040094

Cited by 5 publications

(11 citation statements)

References 16 publications

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“…Cu or CuONPs have been revealed synergistic effects when combined with gentamicin, doxycycline and amoxicillin/clavulamic acid against E. coli, P. aeruginosa, B. cereus, P. mirabilis and S. aureus. 106,131,132 Vernaya et al (2020) showed the efficacy of FeNPs as a promising precursor of targeted drug delivery systems. In this work, gentamycin was combined with chemical synthesized FeNPs.…”

Section: Methods Amentioning

confidence: 99%

“…In this work, gentamycin was combined with chemical synthesized FeNPs. 106 Only three works were found displaying the development of bimetallic NPs and posterior conjugation with antibiotics, in particular: Ag-Au, Ag-Pt and Cu-Zn nanoparticles. efficient against all pathogens than individual AgNPs or PtNPs.…”

Section: Methods Amentioning

confidence: 99%

“…In this work, gentamycin was combined with chemically synthesized FeNPs. 106 Only three works were found to display the development of bimetallic NPs and posterior conjugation with antibiotics, in particular Ag−Au, Ag−Pt, and Cu−Zn nanoparticles. Fakhri et al tested the synergistic antimicrobial activity of doxycyclineconjugated bimetallic Ag−AuNPs against P. aeruginosa, E. coli, S. aureus, and M. luteus, showing promising results for burn healing therapy.…”

Section: Therapeutic Agents Conjugated With Mnps and Antimicrobial Ef...mentioning

confidence: 99%

“…Vernaya et al showed the efficacy of FeNPs as promising precursors of targeted drug delivery systems. In this work, gentamycin was combined with chemically synthesized FeNPs …”

Section: Therapeutic Agents Conjugated With Mnps and Antimicrobial Ef...mentioning

confidence: 99%

See 3 more Smart Citations

Synergistic Effects Between Metal Nanoparticles and Commercial Antimicrobial Agents: A Review

Ribeiro

Dias

Zille

2022

ACS Appl. Nano Mater.

128

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Nanotechnology has expanded into a broad range of clinical applications. In particular, metal nanoparticles (MNPs) display unique antimicrobial properties, a fundamental function of novel medical devices. Combining MNPs with commercial antimicrobial drugs (e. g., antibiotics, antifungals and antivirals) may offer several opportunities to overcome some disadvantages of their individual use and enhance effectiveness. MNPs-conjugates display multiple advantages. As drug delivery systems, the conjugates can extend the circulation of the drugs in the body, facilitate intercellular targeting, improve drug stabilization, and possess superior delivery. Concomitantly, they reduce the required drug dose, minimize toxicity and broaden the antimicrobial spectrum. In this work, the common strategies to combine MNPs with clinically used antimicrobial agents are underscored. Furthermore, a comprehensive survey about synergistic antimicrobial effects, mechanism of action and cytotoxicity is depicted. SilverAntimicrobial, drug deliver, anticancer, anti-angiogenic and biosensors 46,47 Gold Drug delivery, catalyst for medical therapy, antimicrobial conjugations, anticancer, gene therapy and diagnostic 48,49 Copper and copper oxide Antimicrobial and catalysis 50, 51 Iron and iron oxideAnticancer therapy, magnetic resonance imaging, targeted drug delivery and cell separation catalysis [52][53][54] Zinc oxide Personal care products, coatings, drug delivery, anticancer and antimicrobial 55, 56Aluminum oxide Drug delivery, biosensing, cancer therapy, antimicrobial, biomolecular preservation, immunotherapy 57 Titanium oxideDrug delivery, photodynamic therapy, cell imaging, biosensors, and genetic engineering, antimicrobial 58,59 Platinum Biomedical devices, anticancer therapies, cardiovascular diseases, bioimaging, nanozymes, biosensors, antimicrobial 60, 61 PalladiumPhotothermal agents, photoacoustic agents, antimicrobial, anticancer, gene/drug carriers, prodrug activators and biosensors 62,63 Scheme 1. MNPs used in biomedical applications. Silver Nanoparticles (AgNPs)AgNPs are the most prevalent inorganic nanoparticles applied as antimicrobial agent. AgNPs have demonstrated high antimicrobial activity comparable to Ag ionic form. However, several concerns have emerged regarding their cytotoxicity. The toxicity mechanisms, long-term accumulation effects and dose-response relationship are still grievously unknown. 64 Gold Nanoparticles (AuNPs)AuNPs are extremely valuable in developing antibacterial agents due to their low toxicity, high propensity for functionalization, eclectic effects, easy detection and photothermal activity. AuNPs per se possess very low antimicrobial activity, but numerous studies on the antimicrobial activity of AuNPs conjugated with small molecules, such as drugs, vaccines and antibodies, have been reported.

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Section: Methods Amentioning

confidence: 99%

Section: Methods Amentioning

confidence: 99%

Section: Therapeutic Agents Conjugated With Mnps and Antimicrobial Ef...mentioning

confidence: 99%

“…Vernaya et al showed the efficacy of FeNPs as promising precursors of targeted drug delivery systems. In this work, gentamycin was combined with chemically synthesized FeNPs …”

Section: Therapeutic Agents Conjugated With Mnps and Antimicrobial Ef...mentioning

confidence: 99%

See 2 more Smart Citations

Synergistic Effects Between Metal Nanoparticles and Commercial Antimicrobial Agents: A Review

Ribeiro

Dias

Zille

2022

ACS Appl. Nano Mater.

128

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show abstract

“…Ampicillin-functionalized Au and Ag INPs produces a combined antibacterial effect that can destroy ampicillin-resistant bacteria [ 136 ]. Cryoformed HNCs of dioxidine and gentamicin combined with Ag and Cu INPs showed an increase in antibacterial activity compared to the separate activity of the individual components [ 144 , 149 , 150 ].…”

Section: Nanocomposites Of Inps With Antibacterial Drug Substancesmentioning

confidence: 99%

Nanoparticles of Bioactive Metals/Metal Oxides and Their Nanocomposites with Antibacterial Drugs for Biomedical Applications

et al. 2022

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The increasing appearance of new strains of microorganisms resistant to the action of existing antibiotics is a modern problem that requires urgent decision. A promising potential solution is the use of nanoparticles of bioactive metals and their oxides as new antibacterial agents, since they are capable of affecting pathogenic microorganisms by mechanisms different from the mechanisms of action of antibiotics. Inorganic nanoparticles possess a wide spectrum of antibacterial activity. These particles can be easily conjugated with drug molecules and become carriers in targeted drug-delivery systems. This paper discusses the benefits and prospects of the application of nanoparticles from metals and metal oxides and their nanocomposites with antibacterial drugs.

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The Synthesis of Maghemite Nanoparticles by Thermal Decomposition of Cryochemically Modified Iron(III) Acetylacetonate

Vernaya

Shumilkin

Шабатин

et al. 2020

Moscow Univ. Chem. Bull.

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Low-Temperature Synthesis and Antibacterial Activity of Hybrid Systems of Gentamicin Sulfate with Copper and Iron Nanoparticles

Cited by 5 publications

References 16 publications

Synergistic Effects Between Metal Nanoparticles and Commercial Antimicrobial Agents: A Review

Synergistic Effects Between Metal Nanoparticles and Commercial Antimicrobial Agents: A Review

Nanoparticles of Bioactive Metals/Metal Oxides and Their Nanocomposites with Antibacterial Drugs for Biomedical Applications

The Synthesis of Maghemite Nanoparticles by Thermal Decomposition of Cryochemically Modified Iron(III) Acetylacetonate

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