Low-temperature synthesis of nanoparticle-assembled, transparent, and low-crystallized hydroxyapatite blocks

Okada, Masahiro; Furuzono, Tsutomu

doi:10.1016/j.jcis.2011.04.068

Cited by 28 publications

(25 citation statements)

References 40 publications

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“…Nevertheless, it was commonly observed that nano-sized crystals of apatites synthesized through the chemical precipitation were often highly agglomerated; however, these agglomerates could be clusters of ultra-fine primary particles [304]. The prepared nanodimensional apatites might be consolidated to transparent bioceramics [330]. A hydrothermal synthesis [69,72,156,157,257,258,288,322,323, seems to be the second most popular preparation technique of the nanodimensional and/or nanocrystalline apatites.…”

Section: Nanodimensional and Nanocrystalline Apatitesmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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Nano-sized particles and crystals play an important role in the formation of calcified tissues of various animals. For example, nano-sized and nanocrystalline calcium orthophosphates in the form of apatites of biological origin represent the basic inorganic building blocks of bones and teeth of mammals. Namely, according the recent developments in biomineralization, tens to hundreds nanodimensional crystals of a biological apatite are self-assembled into these complex structures. This process occurs under a strict control by bioorganic matrixes. Furthermore, both a greater viability and a better proliferation of various types of cells have been detected on smaller crystals of calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the hard tissue-engineering field, starting from bone repair and augmentation to controlled drug delivery systems. This review reports on current state of the art and recent developments on the subject, starting from synthesis and characterization to biomedical and clinical applications. Furthermore, the review also discusses possible directions for future research and development.

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Section: Nanodimensional and Nanocrystalline Apatitesmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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“…The morphology of amorphous nanoparticles is generally spherical, whereas that of crystalline nanoparticles is determined thermodynamically or kinetically according to the surface energy or reaction rate constant of each crystalline plane 33) . In this study, chemical precipitation under the alkaline conditions at low temperature (25°C) resulted in the formation of spherical nanoparticles, which was likely due to the formation of ACP, as it has no specific crystalline planes and a relatively low Ca/P ratio at the initial stage 34) . The increase in preparation temperature led to the formation of rod-shaped nanocrystals with a crystal structure of a hexagonal prism.…”

Section: Discussionmentioning

confidence: 80%

“…Note that the HAp nanoparticles used for the adsorption tests in this study should be weakly flocculated 39) , and the drying of the nanoparticle dispersion generally induces the formation of severe aggregation that decreases the surface area of the nanoparticles 34,40) . Therefore, the nanoparticles for CPC adsorption tests were used without drying after the preparation.…”

Section: Discussionmentioning

confidence: 99%

Adsorption and desorption behaviors of cetylpyridinium chloride on hydroxyapatite nanoparticles with different morphologies

et al. 2016

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Application of hydroxyapatite (HAp) nanoparticles to repair damaged enamel has attracted recent attention. In this study, HAp nanoparticles with various morphologies (spherical, short-rod, long-rod and fiber morphologies) were synthesized via chemical precipitation methods without the addition of template molecules, and the adsorption/desorption behaviors of a cationic antibacterial agent, cetylpyridinium chloride (CPC), on the HAp nanoparticles were evaluated. The adsorption of CPC on each HAp nanoparticle showed Langmuir-type adsorption, and the short-rod/long-rod HAp nanoparticles showed thermodynamically more stable adsorption of CPC than that with the spherical/fiber HAp nanoparticles. The desorption rate of CPC from the short-rod/long-rod HAp nanoparticles was slower than that of the spherical/fiber HAp nanoparticles. The HAp nanoparticles with different CPC release profiles presented here have potential applications as nanoparticulate enamel repair agents with antibacterial properties.

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“…With respect to synthesis strategies to obtain colloidal nanoparticles of HA, there are various methods such as hydrothermal, [16][17][18][19] chemical precipitate, 20,21 wet chemical, 22,23 and sol-gel 24 methods. Among these, the hydrothermal method has aroused great interest due to its good repeatability, wide temperature range, the possibility to control the form, size, and shape, simplicity of operation, ability to produce crystalline nanoparticles without posterior thermal treatment, 25 and especially to obtain stable colloidal suspensions of nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

“…In this work an empirical model that allows the control of the shape and size of HA nanoparticles due to the control of the initial experimental conditions was proposed. Although studies using factorial design to understand the effect of some experimental conditions on the final properties of colloidal HA nanoparticles have been previously published, 19,21,22,24,25,28,29,31 only a few of them evaluated the statistical significance of the effects. Usually, these studies present models that consider the experimental parameters that affect the size of the particles, which were previously identified in univariate studies, but their statistical significance has been ignored, which is not true in multivariate studies.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Optimization of Colloidal Hydroxyapatite Nanoparticles by Hydrothermal Processes

Arantes¹,

Coimbra²,

Cristovan³

et al. 2018

J. Braz. Chem. Soc.

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This paper reports an optimized, simple, fast and inexpensive method for hydroxyapatite (HA) nanoparticle synthesis. Through a multivariate statistical analysis using a factorial design with 2 3 resolution, an empirical model was developed which allows control of the shape and size of the HA nanoparticles. This model was used to synthesize HA nanoparticles with sizes between 8 and 600 nm, formed by oriented attachment growth mechanism. The structure was confirmed by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) images, which also showed that HA nanoparticles had well-defined nanorod forms and narrow size distributions. It was observed that the model is statistically significant and the main parameter for the growth of crystals in the hydrothermal process was temperature.

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Low-temperature synthesis of nanoparticle-assembled, transparent, and low-crystallized hydroxyapatite blocks

Cited by 28 publications

References 40 publications

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Adsorption and desorption behaviors of cetylpyridinium chloride on hydroxyapatite nanoparticles with different morphologies

Synthesis and Optimization of Colloidal Hydroxyapatite Nanoparticles by Hydrothermal Processes

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