Low testosterone elevates interleukin family cytokines in a rodent model: a possible mechanism for the potentiation of vascular disease in androgen-deficient males

Freeman, Brian M.; Mountain, Deidra J.H.; Brock, Timothy C.; Chapman, Jason R.; Kirkpatrick, Stacy S.; Freeman, Michael B.; Klein, Frederick; Grandas, Oscar H.

doi:10.1016/j.jss.2014.03.017

Cited by 38 publications

(26 citation statements)

References 49 publications

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“…We did not strive to determine the biological mechanisms associated with this pro‐resorptive role of testosterone, but we speculate it may be an indirect effect, mediated by regulation of local production of inflammatory and bone‐resorptive mediators. However, in contrast with the putative immunosuppressive effect associated with testosterone depletion, there is evidence that reduced testosterone levels are associated with increased serum levels of IL‐2, ‐6, ‐10, and ‐12; whereas exogenous testosterone replacement reduced the serum levels to near hormone‐competent control level . Differences in the experimental approach may account for these discrepancies, as the age (12 months vs 4 to 5 months) and strain (Sprague‐Dawley vs Holtzman) of the rats used were different.…”

Section: Discussionmentioning

confidence: 99%

“…However, in contrast with the putative immunosuppressive effect associated with testosterone depletion, there is evidence that reduced testosterone levels are associated with increased serum levels of IL-2, -6, -10, and -12; whereas exogenous testosterone replacement reduced the serum levels to near hormone-competent control level. 30 Differences in the experimental approach may account for these discrepancies, as the age (12 months vs 4 to 5 months) and strain (Sprague-Dawley vs Holtzman) of the rats used were different. Moreover, testosterone depletion lasted 4 weeks in the previous study, as opposed to the 8-week period of hormone depletion in the present study.…”

Section: Discussionmentioning

confidence: 99%

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Long‐term testosterone depletion attenuates inflammatory bone resorption in the ligature‐induced periodontal disease model

Gonçalves

Ortega

Steffens

et al. 2018

Journal of Periodontology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Long‐term testosterone depletion attenuates inflammatory bone resorption in the ligature‐induced periodontal disease model

Gonçalves

Ortega

Steffens

et al. 2018

Journal of Periodontology

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“…It has been shown that estrogens may modify the production of Th1, Th2 and Th17 cytokines by peripheral blood mononuclear cells [18]. Additionally, the release of the cytokines IL-2, IL-6, IL-10, IL-12, and IL-13 may be dependant on testosterone [19]. …”

Section: Discussionmentioning

confidence: 99%

Increased plasma concentrations of interleukin 35 in patients with coronary artery disease

Gorzelak-Pabiś¹,

Chałubiński²,

Wojdan³

et al. 2017

aoms

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IntroductionAtherosclerosis leading to coronary artery disease (CAD) is a chronic inflammatory condition. Interleukin 35 (IL-35) released by regulatory T cells (Tregs) has been found to be associated with CAD in the Chinese population. However, nothing is known about the relation between IL-35 concentrations and cholesterol levels. The aim of the study was to assess the levels of IL-35 in CAD patients and healthy subjects from a Caucasian population, and to analyze the relationship between IL-35 and the levels of total cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, left ventricular ejection fraction (LVEF), sex and postmenopausal status.Material and methodsThirty-one patients with CAD and 30 healthy controls were included in the study. Levels of plasma IL-35 were analyzed by ELISA. The LVEF was assessed by transthoracic echocardiographic examination. Plasma levels of cholesterol fractions and C-reactive protein (CRP) were assessed by immunoenzymatic methods.ResultsThe CAD patients had higher levels of IL-35 as compared to healthy controls (58.1 ±16.6 pg/ml vs. 5.35 ±3.35 pg/ml; p < 0.001). IL-35 levels negatively correlated with total and LDL cholesterol concentrations (R = –0.31, p < 0.01) and positively correlated with HDL cholesterol in men (R = 0.53, p < 0.01). In women, IL-35 levels negatively correlated with LVEF (R = –0.29, p < 0.05) and positively with the duration of postmenopausal status (R = 0.55, p < 0.01).ConclusionsThese results suggest a possible association between high levels of IL-35 and CAD.

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“…In in vitro studies, testosterone produced a shift from Th1 to Th2 response by reduction in TNF‐α or IL‐6 secretion, inhibition of proliferation of T cells and apoptosis (Bebo et al ., ; D'Agostino et al ., ; Huber et al ., ; Liva & Voskuhl, ; Kissick et al ., ). In male rats with lower‐than‐normal serum T levels, a decrease in IL‐2, IL‐6, IL‐10, IL‐12 and IL‐13 occurs which is reversed with testosterone supplementation (Freeman et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Hypogonadal men with psoriasis benefit from long-term testosterone replacement therapy - a series of 15 case reports

Saad

Haider²,

Gooren

2015

Andrologia

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Psoriasis is increasingly recognised as a skin disease with far-reaching systemic effects, associated with a high prevalence of comorbid disease such as cardiometabolic dysfunction, shifting the focus from a single organ disease confined to the skin to a systemic inflammatory condition. Chronic and systemic inflammation plays a major role in the development of these diseases, and there are striking similarities between the molecular and inflammatory pathways in psoriasis and atherosclerosis. In a single-centre, cumulative, prospective registry study of 347 hypogonadal men (total testosterone ≤12.1 nmol l(-1) ), fifteen men with psoriasis could be studied. Upon testosterone administration, the skin disease improved considerably. Scores on the Psoriasis Area and Severity Index and Physician Global Assessment for Psoriasis showed significant improvement for the first 24 months. Thereafter, these improvements were sustained. Upon testosterone treatment, C-reactive protein declined significantly. There were significant improvements of obesity and of lipid profiles. Adipose tissue is now regarded as a source of inflammatory factors. These preliminary results deserve to be studied in a specifically designed study to investigate the effects of testosterone on psoriasis and its associated immunopathology.

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Low testosterone elevates interleukin family cytokines in a rodent model: a possible mechanism for the potentiation of vascular disease in androgen-deficient males

Cited by 38 publications

References 49 publications

Long‐term testosterone depletion attenuates inflammatory bone resorption in the ligature‐induced periodontal disease model

Long‐term testosterone depletion attenuates inflammatory bone resorption in the ligature‐induced periodontal disease model

Increased plasma concentrations of interleukin 35 in patients with coronary artery disease

Hypogonadal men with psoriasis benefit from long-term testosterone replacement therapy - a series of 15 case reports

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