Low Turnover Renal Osteodystrophy With Abnormal Bone Quality and Vascular Calcification in Patients With Mild-to-Moderate CKD

El-Husseini, Amr; Abdalbary, Mohamed; Lima, Florence; Issa, Mohamed; Ahmed, Mohamed Tarek; Winkler, Michael; Srour, Habib; Davenport, Daniel L.; Wang, Guodong; Faugère, Marie-Claude; Malluche, Hartmut H.

doi:10.1016/j.ekir.2022.02.022

Cited by 16 publications

(24 citation statements)

References 66 publications

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“…Patients' age, urea, creatinine, phosphorus, and alkaline phosphatase all had positive relationships with the association, which was negative for calcium and GFR (P0.05). A positive association between FGF23 serum levels and serum phosphate levels was shown by Van Husen et al, 2010 (16) (17) discovered that only GFR at the beginning of the study, c-terminal FGF23, and intact FGF23 remained significant.…”

Section: Resultsmentioning

confidence: 76%

“…In addition, bone mineralization was impaired and bone formation was reduced. In Ferreira A. C., et al, 2022 (16), high levels of PTH and a younger age were linked to rapid bone turnover. Low levels of PTH and advanced age, on the other hand, were linked to lower bone turnover.…”

Section: Resultsmentioning

confidence: 96%

“…There was also a decrease in the rate of bone formation and a reduction in bone mineralization. Osteoporosis was discovered in just 6.5 percent of patients with DXA-measured BMD, whereas no patients had osteoporosis in the lower back or whole hip, according to a study by El-Husseini A, et al, 2022 (16). A total of 44.8 percent of patients were found to have osteopenia at the whole hip, 35.5% at the femoral neck, and 9.7% at the lumbar spine.…”

Section: Resultsmentioning

confidence: 98%

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Serum Fibroblast Growth Factor 23 as an Early Biomarker for Detection of Renal Osteodystrophy and Progression of Chronic Kidney Disease in Children

A.Kamel

Elhamshary

Abdelgwad

et al. 2022

Benha Journal of Applied Sciences

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Background: Chronic kidney disease (CKD) is a major public health issue that imposes significant financial burdens on health systems across the world. Calcium and phosphorus levels in the blood are maintained by tubular reabsorption systems in the kidneys. Changes in the mineral metabolism occur as renal disease progresses. Chronic hyperphosphatemia causes FGF23 levels to rise in later stages of CKD. Bone cells are the major source of FGF23's secretion. The regulation of mineral ion homeostasis by FGF23 has been shown. Methods: Sixty youngsters will participate in the trial, which was done at the paediatric nephrology section of Benha University Hospital. Group I consists of 40 individuals with end-stage renal disease. Divided into the following groups based on GFR: Patients in CKD stages I, II, III, and IV were followed up in our paediatric nephrology clinic every three or six months, depending on their health. 2-Patients with CKD stage V were included in subgroup IB (n = 25). (undergoing regular hemodialysis three times per week, with each dialysis session lasting three to four hours). Group II: consists of 20 youngsters who seem to be in good health. It was made up of 10 men and 10 women, all of whom seemed to be of the same age, sex, and social status. Submissions came from all of the subjects: Blood count in its entirety (CBC), Serum creatinine level, blood urea nitrogen (BUN), serum calcium (Ca), serum phosphorus (Po4), serum alkaline phosphatase (ALP), parathyroid hormone (PTH), serum fibroblast growth factor 23 (FGF23) were all measured in this study. We discovered 24 patients with normal radiological results, 14 patients with subperiosteal bone resorption, seven patients with pathological fractures, and one patient with brown tumours (2.5 percent ). We found that the concentration of FGF23 in group I (532.5 pg/ml vs. 124.9 pg/ml) was statistically significantly higher than the control group (124.9pg/ml). We discovered a cutoff point of 159.7 pg/ml with a sensitivity of 85%, specificity of 90%, accuracy of 80%, PPV of 94.4 %, NPP of 75%, AUROC of 0.837, and a P value of 0.0001 for FGF23 in predicting CKD. It may be concluded that the early biomarker FGF 23 can be utilised to track the progression of chronic kidney disease in kids.

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Section: Resultsmentioning

confidence: 76%

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 98%

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Serum Fibroblast Growth Factor 23 as an Early Biomarker for Detection of Renal Osteodystrophy and Progression of Chronic Kidney Disease in Children

A.Kamel

Elhamshary

Abdelgwad

et al. 2022

Benha Journal of Applied Sciences

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“…We read with interest the article “Low Turnover Renal Osteodystrophy With Abnormal Bone Quality and Vascular Calcification in Patients With Mild-to-Moderate CKD” by El-Husseini et al. 1 On the basis of bone biopsy findings, the authors reported that low turnover bone (LTB) disease was the most prevalent pattern of renal osteodystrophy in patients with early CKD stages 2 to 3, with a prevalence of 84%. This finding is in agreement with previous reports by Coen et al.…”

mentioning

confidence: 99%

“…Finally, El-Husseini et al. 1 claim that Fourier transform infrared spectroscopy has added value in evaluating bone quality in LTB disease. We wonder whether the assessment of bone mineral-to-matrix ratio by infrared spectroscopy allows an accurate evaluation of bone quality and strength as bone histomorphometry in patients with CKD with LTB disease.…”

mentioning

confidence: 99%