Low Vitamin B12 and Parkinson Disease

McCarter, Stuart J.; Teigen, Levi; McCarter, Allison R.; Benarroch, Eduardo E.; Louis, Erik K. St.; Savica, Rodolfo

doi:10.1016/j.mayocp.2019.01.039

Cited by 22 publications

(7 citation statements)

References 34 publications

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“…In relation to OCM, there is growing evidence of a possible role of B-vitamins in PD onset and development, especially in patients with cognitive impairment ( Seidl et al, 2014 ; McCarter et al, 2019 ). This potential role is supported by the fact that folate, the natural form of vitamin B9, and the synthetic food additive folic acid are essential cofactors in homocysteine metabolism.…”

Section: C Metabolism and Parkinson’s Diseasementioning

confidence: 99%

Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases

Bou Ghanem,

Hussayni,

Kadbey

et al. 2024

Front. Aging Neurosci.

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The intricate interplay of one-carbon metabolism (OCM) with various cellular processes has garnered substantial attention due to its fundamental implications in several biological processes. OCM serves as a pivotal hub for methyl group donation in vital biochemical reactions, influencing DNA methylation, protein synthesis, and redox balance. In the context of aging, OCM dysregulation can contribute to epigenetic modifications and aberrant redox states, accentuating cellular senescence and age-associated pathologies. Furthermore, OCM’s intricate involvement in cancer progression is evident through its capacity to provide essential one-carbon units crucial for nucleotide synthesis and DNA methylation, thereby fueling uncontrolled cell proliferation and tumor development. In neurodegenerative disorders like Alzheimer’s and Parkinson’s, perturbations in OCM pathways are implicated in the dysregulation of neurotransmitter synthesis and mitochondrial dysfunction, contributing to disease pathophysiology. This review underscores the profound impact of OCM in diverse disease contexts, reinforcing the need for a comprehensive understanding of its molecular complexities to pave the way for targeted therapeutic interventions across inflammation, aging and neurodegenerative disorders.

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Section: C Metabolism and Parkinson’s Diseasementioning

confidence: 99%

Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases

Bou Ghanem,

Hussayni,

Kadbey

et al. 2024

Front. Aging Neurosci.

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“…Vitamins A, C, and E have strong antioxidant properties. Oxidative damage causes DNA to become a poor substrate for DNMTs, thereby producing a state of global hypomethylation [ 78 , 100 ]. Oxidation may also change the histone acetylation balance.…”

Section: Treatment Of Neurodegenerative Disorders With Epinutraceutic...mentioning

confidence: 99%

“…Curcumin is used to treat dyspepsia, stress, and mood disorders [ 132 ] and is a specific inhibitor of p300/CREB-binding protein (CBP) HAT activity [ 133 ]. In some brain diseases, HAT inhibition decreases nuclear histone acetylation, leading to inhibition of the NF-κB pathway [ 100 , 102 , 103 ]. P300/CBP acetylates NF-κB, and curcumin inhibits p-300 mediated acetylation of the isoform of NF-κB RelA [ 134 ].…”

Section: Treatment Of Neurodegenerative Disorders With Epinutraceutic...mentioning

confidence: 99%

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Natural Bioactive Products as Epigenetic Modulators for Treating Neurodegenerative Disorders

et al. 2023

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Neurodegenerative disorders (NDDs) are major health issues in Western countries. Despite significant efforts, no effective therapeutics for NDDs exist. Several drugs that target epigenetic mechanisms (epidrugs) have been recently developed for the treatment of NDDs, and several of these are currently being tested in clinical trials. Furthermore, various bioproducts have shown important biological effects for the potential prevention and treatment of these disorders. Here, we review the use of natural products as epidrugs to treat NDDs in order to explore the epigenetic effects and benefits of functional foods and natural bioproducts on neurodegeneration.

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“…Studies have found that early VitB12 supplementation can delay cognitive decline, reduce brain atrophy, and reduce the incidence of dementia and Alzheimer’s disease (AD) later in life. 20 , 21 Our previous study found that methylcobalamin (MeCbl) supplementation alleviated cognitive impairment induced by PM 2.5 in C57BL/6 mice. 22 However, there are few reports on the effect of PM 2.5 , through dysregulation of gut microbiota, on cognitive ability.…”

Section: Introductionmentioning

confidence: 99%

PM _2.5 induced neurotoxicity through unbalancing vitamin B12 metabolism by gut microbiota disturbance

Zhu,

Xia,

Wang

et al. 2023

Gut Microbes

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Fine particulate matter (PM 2.5 ) in the atmosphere is easily accompanied by toxic and harmful substances, causing serious harm to human health, including cognitive impairment. Vitamin B12 (VitB12) is an essential micronutrient that is synthesized by bacteria and contributes to neurotransmitter synthesis as a nutrition and signaling molecule. However, the relationship between VitB12 attenuation of cognitive impairment and intestinal microbiota regulation in PM 2.5 exposure has not been elucidated. In this study, we demonstrated that PM 2.5 caused behavioral defects and neuronal damage in Caenorhabditis elegans ( C. elegans ), along with significant gene expression changes in neurotransmitter receptors and a decrease in VitB12 content, causing behavioral defects and neuronal damage in C. elegans . Methylcobalamin (MeCbl), a VitB12 analog, alleviated PM 2.5 -induced neurotoxicity in C. elegans . Moreover, using in vivo and in vitro models, we discovered that long-term exposure to PM 2.5 led to changes in the structure of the gut microbiota, resulting in an imbalance of the VitB12-associated metabolic pathway followed by cognitive impairment. MeCbl supplementation could increase the diversity of the bacteria, reduce harmful substance contents, and restore the concentration of short-chain fatty acids (SCFAs) and neurotransmitters to the level of the control group to some degree. Here, a new target to mitigate the harm caused by PM 2.5 was discovered, supplying MeCbl for relieving intestinal and intracellular neurotransmitter disorders. Our results also provide a reference for the use of VitB12 to target the adjustment of the human intestinal microbiota to improve metabolic disorders in people exposed to PM 2.5 .

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Low Vitamin B12 and Parkinson Disease

Cited by 22 publications

References 34 publications

Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases

Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases

Natural Bioactive Products as Epigenetic Modulators for Treating Neurodegenerative Disorders

PM _2.5 induced neurotoxicity through unbalancing vitamin B12 metabolism by gut microbiota disturbance

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Low Vitamin B12 and Parkinson Disease

Cited by 22 publications

References 34 publications

Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases

Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases

Natural Bioactive Products as Epigenetic Modulators for Treating Neurodegenerative Disorders

PM 2.5 induced neurotoxicity through unbalancing vitamin B12 metabolism by gut microbiota disturbance

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PM _2.5 induced neurotoxicity through unbalancing vitamin B12 metabolism by gut microbiota disturbance