Low Vitamin B12 level as a risk factor for very early recurrent abortion

Reznikoff-Etiévant, M.F.; Zittoun, J; Vaylet, C. de Labriolle; Pernet, Pierre; Milliez, Jacques

doi:10.1016/s0301-2115(02)00100-8

Cited by 68 publications

(29 citation statements)

References 14 publications

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“…Recent observational studies suggest that maternal vitamin B-12 deficiency is associated with increased risk of pregnancy complications, such as NTDs (65,(68)(69)(70)(71)(72)80), spontaneous abortions (73)(74)(75), preeclampsia (65), and LBW (76,77,99). However, most studies were case-control or cross-sectional in design, which constrains the interpretability of findings and causal inference.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have examined the associations of maternal vitamin B-12 status and risk of adverse fetal outcomes, including spontaneous abortions. In a study in France, maternal vitamin B-12 deficiency (serum vitamin B-12: <180 pg/L) was associated with a 9-fold greater odds of early recurrent abortion ($2 consecutive abortions with the same partner with <12 wk of amenorrhea), compared with replete vitamin B-12 status (OR: 9.5; 95% CI: 1.2, 75; P < 0.05) (75). In a study among Syrian women, higher maternal vitamin B-12 concentrations were associated with lower odds of recurrent pregnancy loss (OR: 0.99; 95% CI: 0.98, 0.99; P = 0.012) (92).…”

Section: Literature Reviewmentioning

confidence: 98%

“…Maternal vitamin B-12 deficiency is associated with increased risk of common pregnancy complications, including spontaneous abortion, recurrent pregnancy loss, smallfor-gestational age (SGA), low birth weight (LBW), intrauterine growth restriction (IUGR), and NTDs (44,65,(68)(69)(70)(71)(72)(73)(74)(75)(76)(77). Infants born to vitamin B-12-deficient women are at increased risk of developmental abnormalities, growth failure, and anemia (18,78).…”

Section: Nutrient-nutrient Interactionsmentioning

confidence: 99%

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Vitamin B-12 and Perinatal Health

Finkelstein

Layden

Stover

2015

Advances in Nutrition

139

104

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Vitamin B-12 deficiency (<148 pmol/L) is associated with adverse maternal and neonatal outcomes, including developmental anomalies, spontaneous abortions, preeclampsia, and low birth weight (<2500 g). The importance of adequate vitamin B-12 status periconceptionally and during pregnancy cannot be overemphasized, given its fundamental role in neural myelination, brain development, and growth. Infants born to vitamin B-12-deficient women may be at increased risk of neural tube closure defects, and maternal vitamin B-12 insufficiency (<200 pmol/L) can impair infant growth, psychomotor function, and brain development, which may be irreversible. However, the underlying causal mechanisms are unknown. This review was conducted to examine the evidence that links maternal vitamin B-12 status and perinatal outcomes. Despite the high prevalence of vitamin B-12 deficiency and associated risk of pregnancy complications, few prospective studies and, to our knowledge, only 1 randomized trial have examined the effects of vitamin B-12 supplementation during pregnancy. The role of vitamin B-12 in the etiology of adverse perinatal outcomes needs to be elucidated to inform public health interventions. Adv Nutr 2015;6:552-63.

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Section: Discussionmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 98%

Section: Nutrient-nutrient Interactionsmentioning

confidence: 99%

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Vitamin B-12 and Perinatal Health

Finkelstein

Layden

Stover

2015

Advances in Nutrition

139

104

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“…There is compelling evidence to indicate that maternal Bvitamin status during the period leading up to and around the time of conception can have a major impact on fertility, pregnancy establishment, and term delivery [1][2][3]. Mild hyperhomocysteinemia is prevalent in subjects polymorphic for a number of enzymes involved in folate/methionine metabolism, and/or who consume diets deficient in B vitamins, such as vitamin B 12 and folate [4].…”

Section: Introductionmentioning

confidence: 99%

B-Vitamin and Homocysteine Status Determines Ovarian Response to Gonadotropin Treatment in Sheep1

Raji

Singh

et al. 2009

Biology of Reproduction

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Maternal B-vitamin status and homocysteinemia can affect fertility and pregnancy establishment, although the direct effects on ovarian follicle and oocyte development are not known. We report on the effects of restricting the supply of vitamin B(12) and methionine from the diet of mature female sheep on ovarian folliculogenesis following follicle-stimulating hormone (FSH) stimulation. The study was split into three batches and involved 76 animals. Surprisingly, the number of growing, estrogen-active antral follicles following FSH treatment was enhanced (P = 0.005) following this dietary intervention. This increase occurred even in the presence of modest live-weight loss (batch 1 only) and depressed plasma insulin concentrations, suggesting a breakdown in the regulation of follicular responsiveness to FSH. This dietary intervention also increased plasma homocysteine concentrations. Physiological concentrations of homocysteine increased granulosa cell proliferation (P < 0.001), estradiol production (P = 0.05), and FSHR transcript expression (P = 0.017) during culture. Transcript levels for growth differentiation factor 9 and bone morphogenetic protein 15 in oocytes from treated ewes were increased (P < 0.05) in the first two batches. Furthermore, regression of BMP receptor 2 (BMPR2) transcript expression and diet on follicle number revealed a significant interaction (P = 0.01); BMPR2 transcript expression was associated with follicle number only in vitamin B(12)/methionine-restricted animals. Because FSHR transcript expression also was positively (P = 0.007) related to follicle number, the effects of diet may have arisen through enhanced FSH and BMP signaling. Although this remains to be confirmed, the data support an intraovarian impact of vitamin B(12)/methionine-deficient diets.

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“…Vitamin B12 deficiency is associated with increased risk for early recurrent abortion (Reznikoff-Etievant et al 2002) and preeclampsia in pregnant women (Refsum 2001) and neural tube defects in infants (Adams et al 1995;Ray and Blom 2003;Groenen et al 2004;Gaber et al 2007). A tripling in the risk for neural tube defects was reported by Ray and coworkers for infants born to women in the lowest quartile of vitamin B12 status compared with the highest quartile (Ray et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Subclinical vitamin B12 deficiency in pregnant women attending an antenatal clinic in Nigeria

VanderJagt

Ujah

Patel

et al. 2009

Journal of Obstetrics and Gynaecology

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Inadequate vitamin B12 status in a pregnant woman increases the risk for adverse maternal and fetal outcomes. The use of serum vitamin B12 concentration alone to assess vitamin B12 status in pregnant women is unreliable because of the decrease in serum vitamin B12 levels in normal pregnancy. The combination of serum vitamin B12 and methylmalonic acid (MMA) concentrations may provide a better estimate of vitamin B12 status. We obtained blood samples from 98 pregnant women in the third trimester at an antenatal clinic in Jos, Nigeria. All subjects were taking iron and folate supplements. Twelve of the subjects had a serum vitamin B12 concentration <148 pmol/l and 18 subjects had a serum MMA level >271 nmol/l. Using a combination of low serum vitamin B12 and elevated MMA concentrations, eight subjects were classified as having subclinical vitamin B12 deficiency. Because of the potential harmful consequences of vitamin B12 deficiency in pregnant women, it would be advisable to add vitamin B12 supplements to the existing regimen of folate and iron supplements currently provided to pregnant women in Nigeria.

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Low Vitamin B12 level as a risk factor for very early recurrent abortion

Cited by 68 publications

References 14 publications

Vitamin B-12 and Perinatal Health

Vitamin B-12 and Perinatal Health

B-Vitamin and Homocysteine Status Determines Ovarian Response to Gonadotropin Treatment in Sheep1

Subclinical vitamin B12 deficiency in pregnant women attending an antenatal clinic in Nigeria

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