Low Vitamin D Status Does Not Adversely Affect Short-Term Functional Outcome After Total Hip Arthroplasty

Unnanuntana, Aasis; Saleh, Anas; Nguyen, Joseph; Sculco, Thomas P.; Cornell, Charles N.; Mancuso, Carol A.; Lane, Joseph M.

doi:10.1016/j.arth.2012.04.027

Cited by 39 publications

(50 citation statements)

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“…Our findings are in agreement with the literature [5,15,18,24,25]. Bogunovic et al [5] (using a 32-ng/ mL cutoff) found that 43% of patients undergoing orthopaedic surgery had subnormal levels.…”

Section: Discussionsupporting

confidence: 83%

“…This particular finding agrees with previous reports [5,13,24,25]. However, in contrast to previous reports, we did not find associations between insufficiency and any other baseline patient characteristic (age, sex, race, comorbidities) (regardless of the threshold used) [5,24,25]. Bogunovic et al [5] found that patients between the ages of 18 and 50 years were at more risk of having inadequate vitamin D levels (p = 0.018), as well as male sex and patients with darker skin tone (black and Hispanics) (p \ 0.001 for both).…”

Section: Discussionsupporting

confidence: 83%

“…Regarding insufficiency and baseline patient characteristics, our patients with insufficiency had higher BMI (using the 20-ng/mL threshold). This particular finding agrees with previous reports [5,13,24,25]. However, in contrast to previous reports, we did not find associations between insufficiency and any other baseline patient characteristic (age, sex, race, comorbidities) (regardless of the threshold used) [5,24,25].…”

Section: Discussioncontrasting

confidence: 57%

“…Bogunovic et al [5] (using a 32-ng/ mL cutoff) found that 43% of patients undergoing orthopaedic surgery had subnormal levels. Unnanuntana et al [25] also found that 46.6% of patients undergoing THA had hypovitaminosis. Evidently, the insufficiency of vitamin D in patients who undergo THA is fairly prevalent, regardless of the threshold value used.…”

Section: Discussionmentioning

confidence: 96%

“…Even though hypovitaminosis D is the accepted term for insufficient or deficient levels [18], in view of the current lack of consensus on what level defines the low end of the normal range (and much more on the derived terms), we will refer to all patients with subnormal levels as patients with insufficiency for the sake of simplicity. What appears clear is that this vitamin is associated with a number of diseases [16,18,26] and, in some reports, with poorer results after surgery [14,15,18]; however, findings on the latter point have varied among studies [24,25].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D Insufficiency in Patients With THA: Prevalence and Effects on Outcome

Lavernia

Villa

Iacobelli

et al. 2013

Clin Orthop Relat Res

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Background The consequences of vitamin D insufficiency in the elderly remain controversial. The prevalence and potential effects of its chronic insufficiency on quality of life and physical function in patients undergoing THA have received little attention.Question/purposes We determined (1) prevalence of preoperative vitamin D insufficiency in patients undergoing THA and (2) relationships of insufficiency to patientperceived outcomes (PPOs) and hip scores. Methods We retrospectively reviewed 62 consecutive patients who underwent 66 primary THAs. We excluded two patients with missing data and the second hip of bilateral THAs, leaving 60 patients (60 hips) for final inclusion. Based on preoperative plasma 25-hydroxyvitamin-D3 levels, patients were retrospectively assigned into a normal or insufficient group. We used two different thresholds (20 and 30 ng/mL) to define insufficiency; groups were set twice. We compared demographics, BMI, American Society of Anesthesiologists score, Charlson Comorbidity Index; albumin, transferrin, calcium levels; and total lymphocyte count between groups. The insufficient group had a higher mean BMI with the 20-ng/mL cutoff but not with the 30-ng/mL cutoff. We compared the 20-ng/mL cutoff groups (adjusting for BMI) and the 30-ng/mL cutoff groups in terms of preoperative and postoperative Quality of Well-being Scale, SF-36, WOMAC, Harris hip, and Merle d'Aubigné-Postel scores. Mean followup was 11 months (range, 3-24 months). Results The prevalence of vitamin D insufficiency was 30% (using 20 ng/mL) and 65% (using 30 ng/mL). Preoperative and postoperative Harris hip and Merle d'Aubigné-Postel scores were lower in patients with

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