Low vitamin D status likely contributes to the link between periodontal disease and breast cancer

Grant, William B.; Boucher, Barbara J.

doi:10.1007/s10549-011-1458-6

Cited by 10 publications

(4 citation statements)

References 15 publications

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“…Low serum levels of 25OHD have been reported to be a risk factor for periodontal disease [24]. Vitamin D may potentially influence periodontal risk by reducing oral inflammation and by promoting antimicrobial peptide production.…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D nutritional status was evaluated according to 25hydroxyvitamin D (25OHD) levels, a good index of vitamin D status, as follows: sufficiency ≥ 30 ng/mL; insufficiency: 21-29 ng/mL, and deficiency: ≤ 20 ng/mL [11]. This classification was used because although the Institute of Medicine's summary conclusions of vitamin D deficiency in relation to bone health reviewed that "practically all persons are sufficient at serum 25OHD levels of at least 20 ng/mL (50 nmol/L)" [23], the relevance of these specific cut points is less clear for some of the other known non classical actions of vitamin D (e.g., ant-inflammatory properties) [24].…”

Section: Exclusion Criteriamentioning

confidence: 99%

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Low Calcium Intake and Hypovitaminosis D Negatively Affect Oral Health in Young Men

Zeni¹

2017

Austin J Dent

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Section: Discussionmentioning

confidence: 99%

Section: Exclusion Criteriamentioning

confidence: 99%

Low Calcium Intake and Hypovitaminosis D Negatively Affect Oral Health in Young Men

Zeni¹

2017

Austin J Dent

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“…A brief summary of evidence supportive to the association of periodontal disease and carcinogenesis is provided in table 1 (77)(78)(79)(80)(81)(82)(83). An extensive analysis of association and cancers of different tissues and organs is beyond the scope of the current paper.…”

Section: Periodontal Inflammation -Prespectives In Carcinogenesismentioning

confidence: 99%

Chronic Inflammation and Carcinogenesis – Emerging Role of Chronic Inflammatory Periodontal Disease

Grover¹,

Kapoor²,

Sehgal³

et al. 2016

Cancer Res Front

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With exponential increase in the number of cases of cancers worldwide in recent past, it is imperative to enhance our understanding about the etiologic and risk factors associated with this seriously morbid condition. Increasing attention has been focussed on chronic infections and inflammatory diseases, implicating a role in carcinogenesis, particularly in developing countries. Periodontal disease is a bacterially induced chronic inflammatory process that affects tooth supporting connective tissue and alveolar bone in the oral cavity, potentially leading to tooth loss. The concept of these diseases as localized entities affecting only the teeth and supporting apparatus has been revised lately, in the light of mounting evidence of periodontal infection's influence on chronic inflammatory disease states. Periodontal disease has been linked to several systemic conditions like cardiovascular diseases, diabetes mellitus, adverse pregnancy outcomes, obesity and cancers, yet underlying mechanisms are still elucidating. The focus of this review article will be an in depth discussion of the role of chronic inflammation, particularly chronic periodontal inflammation in causation or association of human cancers and discussion of possible biological mechanisms involved.

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“…(2011), showed that low Vitamin D status contributes to the link between periodontal disease and breast cancer. [21]…”

Section: Introductionmentioning

confidence: 99%

Poor periodontal health: A cancer risk?

Rajesh

Thomas

Hegde

et al. 2013

J Indian Soc Periodontol

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Evidence indicates that chronic infections and inflammation are associated with increased risk of cancer development. There has also been considerable evidence that proves the interrelationship between bacterial and viral infections and carcinogenesis. Periodontitis is a chronic oral infection thought to be caused by gram-negative anaerobic bacteria in the dental biofilm. Periodontal bacteria and viruses may act synergistically to cause periodontitis. Many studies have shown that periodontal pockets may act as reservoirs for human papilloma virus, cytomegalovirus, Epstein Barr virus, and suspected agents associated with oral cancer. Periodontitis, characterized by epithelial proliferation and migration, results in a chronic release of inflammatory cytokines, chemokines, growth factors, prostaglandins, and enzymes, all of which are associated with cancer development. This review article intends to shed light on the association between periodontal health and carcinogenesis.

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Low vitamin D status likely contributes to the link between periodontal disease and breast cancer

Cited by 10 publications

References 15 publications

Low Calcium Intake and Hypovitaminosis D Negatively Affect Oral Health in Young Men

Low Calcium Intake and Hypovitaminosis D Negatively Affect Oral Health in Young Men

Chronic Inflammation and Carcinogenesis – Emerging Role of Chronic Inflammatory Periodontal Disease

Poor periodontal health: A cancer risk?

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