The forthcoming property of this manuscript is its calculating of the goal of norms and lower bounds of matrix operators taken from the weighted sequence space ℓp(w) onto a novel one defined in the present article as the generalized Fibonacci weighted difference sequence space. In this process, first of all the Fibonacci difference matrix F˜(r,s) and the space composed of sequences of which F˜(r,s)-transforms lie in ℓp(w˜), where r,s∈R are defined. Additionaly, since the seminormed space ℓp(w˜,F˜(r,s)) has the absolute homogeneous property, the topological characteristics on it are distributed symmetrically everywhere in the space.