Lower circulating irisin is associated with type 2 diabetes mellitus

Liu, Jing; Wong, Melvin D.S.; Toy, Wan Ching; Tan, Clara; Liu, Sylvia; Ng, Xiao Wei; Tavintharan, Subramaniam; Sum, Chee Fang; Lim, Su Chi

doi:10.1016/j.jdiacomp.2013.03.002

Cited by 393 publications

(408 citation statements)

References 23 publications

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“…The current and previously published results (Huh et al, 2012;Liu et al 2013;Park et al, in press;Stengel et al, 2012) mutually reinforce the correlation of irisin with BMI and strongly suggest that plasma irisin levels reflect the net adipose tissue in humans. Moreover, it was described a positive correlation between FNDC5 muscle Non-regainers subjects with successful weight maintenance (n 5 38) and regainers, subjects with weight regain 4 months after ending the hypocaloric diet (n 5 39).…”

Section: Discusionsupporting

confidence: 86%

“…Surprisingly, a recent report has revealed a significant decrease in circulating irisin and adipose and muscle tissue gene expression levels in obesity, suggesting that irisin is inversely associated with different adiposity markers (Moreno-Navarrete et al, 2013). On the other hand, low circulating irisin levels were associated with chronic kidney disease (Wen et al, 2013), intrahepatic triglycerides content in obese adults with non alcoholic fatty liver disease (Zhang et al, 2013) and with type 2 diabetes (Choi et al, 2013;Liu et al, 2013). All together these reports highlight the need of further research to elucidate the true role of irisin in health and disease (Polyzos et al, 2013).…”

Section: Discusionmentioning

confidence: 98%

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Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Crujeiras

Pardo

Roca-Rivada

et al. 2013

American J Hum Biol

129

117

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Objective: The recently discovered peptide irisin has been hypothesized to be a regulator of body metabolism. The objective of this work was to evaluate whether circulating human irisin levels are modulated by body size and changes in adiposity during an energy restriction treatment and the subsequent weight regain.Methods: A group of 94 obese patients (50 men, 44 women; 49.4 6 9.4 years; BMI 35.6 6 4.5 kg/m 2 ) participated in a weight loss program following an 8-week hypocaloric diet (230% energy expenditure) with a weight maintenance follow-up. The patients were evaluated at 0, 8, and 24 weeks after starting treatment. In addition, 48 normal-weight subjects (16 men, 32 women; 35.71 6 8.8 years; BMI 22.9 6 2.2 kg/m 2 ) participated as controls. Plasma irisin, body weight, body composition, and hormones controlling energy homeostasis were measured.Results: Irisin levels were higher in obese subjects (353.1 6 18.6 ng/mL) than in those of normal-weight (198.4 6 7.8 ng/mL; P 0.001) and were also higher in men (340.9 6 20 ng/mL) than in women (267.6 6 12 ng/mL; P < 0.05). Moreover, irisin plasma levels were significantly correlated with high levels of direct and indirect adiposity markers, such as weight, BMI, waist circumference, and fat mass, as measured by bioimpedance, but not with height or leptin levels. Interestingly, irisin levels paralleled body weight reduction after the dietary treatment (week 8) and again returned to the baseline levels at 24 weeks in those patients regaining the lost weight.Conclusions: Irisin strongly reflects body fat mass, suggesting that the irisin circulating levels are conditioned by adiposity level. Am. J. Hum. Biol. 26:198-207, 2014.

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Section: Discusionsupporting

confidence: 86%

Section: Discusionmentioning

confidence: 98%

Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Crujeiras

Pardo

Roca-Rivada

et al. 2013

American J Hum Biol

129

117

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“…There is a possibility that irisin may be a surrogate marker for MetS. Most studies in adults showed that levels of irisin were linked to the incidence of T2DM [7], insulin resistance [19,20], and dyslipidemia [21], which are components of MetS. However, there were discrepancies reporting the relationship between irisin and metabolic diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Myokines are induced by exercise in rodents and humans, are related to browning in adipose tissue and are found to increase energy expenditure in mice without influencing movement and food intake, leading to a decrease in obesity and an improvement in glucose homeostasis [6]. Recent studies have reported that irisin is linked to T2DM [7] and MetS [8] in adults. However, there are only a few studies that have evaluated the relationship between irisin and MetS in pediatrics.…”

mentioning

confidence: 99%

Irisin is a biomarker for metabolic syndrome in prepubertal children

et al. 2018

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Abstract. The aim of the present study was to evaluate the association of irisin with obesity and metabolic syndrome (MetS) in Korean prepubertal children. A total of 96 children and adolescents aged 6 to 10 years (56 males) were included in this study. Subjects were divided into 3 groups: normal weight (n = 54), overweight (n = 16), and obese (n = 26). In the subgroup analyses, overweight/obese children were further divided based on their MetS status (with MetS vs. without MetS). Children with obesity tended to exhibit a lower mean irisin concentration compared to those with normal weight (p = 0.028). Using Pearson's correlation coefficient to compare all the children in the study, there was a significant inverse correlation between irisin and body mass index (BMI) standard deviation scores (SDS) (r = -0.210, p = 0.041), waist circumference SDS (r = -0.203, p = 0.049), and glucose (r = -0.296, p = 0.004). In the subgroup analyses of overweight/obese children, irisin exhibited a significant inverse correlation with glucose (r = -0.507, p = 0.001) and triglycerides (r = -0.331, p = 0.033). Children with MetS exhibited lower irisin concentrations than those without MetS (14.70 ng/mL vs. 22.02 ng/mL, p = 0.001), and these associations were significant after adjusting for age, gender, and BMI SDS (14.51 ng/mL vs. 22.06 ng/mL, p = 0.002). The irisin level of 15.43 ng/mL was determined to be a possible cutoff to distinguish children with metabolic syndrome from overweight/obese children, with a sensitivity of 75% and a specificity of 94% (p < 0.001). Our results suggest that decreased irisin levels may be associated with MetS in prepubertal children and that irisin might be a biomarker for MetS in prepubertal children. WITH an increasing population of overweight and obese children, metabolic complications associated with being overweight/obese, such as insulin resistance, hypertension and dyslipidemia, have become a major public health concern [1]. The incidence of childhood metabolic syndrome (MetS), which is closely related to insulin resistance, is defined as a clustering of abdominal obesity, hypertension, dyslipidemia and glucose intolerance and is increasing around the world, including in Korea [2]. The clustering of metabolic risk factors begins in childhood [3], and these multiple risk factors tend to persist from childhood into adulthood [4]. Childhood MetS is a risk factor for MetS, cardiovascular diseases and Submitted Jun. 15, 2017; Accepted Aug. 16, 2017 as EJ17-0260 Released online in J-STAGE as advance publication Sep. 12, 2017 Correspondence to: Il Tae Hwang, MD, PhD, Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Hallym University College of Medicine, 150 Seongan-ro, Gangdong-gu, Seoul, Korea, 05338 E-mail: ithwang83@hallym.or.kr type 2 diabetes mellitus (T2DM) in adulthood [5]. It is therefore important to identify early MetS in children and adolescents.Recently, adipokines (i.e., adipocyte-secreted proteins) and myokines (i.e., myocyte-secreted proteins) have been s...

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“…Interestingly, the K153R polymorphism in the gene (MSTN) encoding myostatin could be associated with EL, as shown by previous research from our group . There is some controversy among the numerous studies that have assessed circulating blood levels of irisin in people with obesity, diabetes, and CVD (Huh et al 2012;Choi et al 2013;Liu et al 2013;MorenoNavarrete et al 2013;Park et al 2013;Stengel et al 2013;Vamvini et al 2013;Sanchis-Gomar et al 2014a;Sanchis-Gomar et al 2014b). Some authors have expressed their concerns about the notion that irisin is a real myokine (i.e., being released by contracting muscles) or that this molecule has actual beneficial effects on health (Timmons et al 2012;Erickson 2013;Pekkala et al 2013;Raschke et al 2013).…”

Section: Discussionmentioning

confidence: 99%

FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs

Sanchís-Gomar

Garatachea

et al. 2014

AGE

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Irisin might play an important role in reducing the risk of obesity, insulin resistance, or several related diseases, and high irisin levels may contribute to successful aging. Thus, the irisin precursor (FNDC5) gene is a candidate to influence exceptional longevity (EL), i.e., being a centenarian. It has been recently shown that two single-nucleotide polymorphisms (SNPs) in the FNDC5 gene, rs16835198 and rs726344, are associated with in vivo insulin sensitivity in adults. We determined luciferase gene reporter AGE (2014) 36:9733 DOI 10.1007 Fabian Sanchis-Gomar and Nuria Garatachea contributed equally to this paper activity in the two above-mentioned SNPs and studied genotype distributions among centenarians (n=175, 144 women) and healthy controls (n=347, 142 women) from Spain. We also studied an Italian [79 healthy centenarians (40 women) and 316 healthy controls (156 women)] and a Japanese cohort [742 centenarians (623 women) and 499 healthy controls (356 women)]. The rs726344 SNP had functional significance, as shown by differences in luciferase activity between the constructs of this SNP (all P≤0.05), with the variant A-allele having higher luciferase activity compared with the G-allele (P = 0.04). For the rs16835198 SNP, the variant T-allele tended to show higher luciferase activity compared with the G-allele (P=0.07). However, we found no differences between genotype/allele frequencies of the two SNPs in centenarians versus controls in any cohort, and no significant association (using logistic regression adjusted by sex) between the two SNPs and EL. Further research is needed with different cohorts as well as with additional variants in the FNDC5 gene or in other genes involved in irisin signaling.

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Lower circulating irisin is associated with type 2 diabetes mellitus

Cited by 393 publications

References 23 publications

Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Irisin is a biomarker for metabolic syndrome in prepubertal children

FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs

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