Lower level of synovial fluid interferon-gamma in HLA-B27-positive than in HLA-B27-negative patients with Chlamydia trachomatis reactive arthritis

S, Bas; Tk, Kvien; Buchs, Nicolas; Fulpius, Thierry; Gabay, Cem

doi:10.1093/rheumatology/keg163

Cited by 43 publications

(27 citation statements)

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“…It is interesting to note that in Chlamydia-induced ReA, synovial fluid levels of IFN␥ were lower in HLA-B27-positive patients than in HLA-B27-negative patients (41). This bears an interesting relationship to our findings in the present study, in which as-yetuncharacterized genetic susceptibility conferring sensitivity to experimental C trachomatis-induced arthritis was also associated with a relative lack of IFN␥ production locally.…”

Section: Host-microbe Interactions In Chlamydia-induced Arthritissupporting

confidence: 81%

Early cytokine profiles in the joint define pathogen clearance and severity of arthritis in Chlamydia‐induced arthritis in rats

Inman

Chiu

2006

Arthritis & Rheumatism

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Objective. Although Chlamydia trachomatisinduced arthritis is among the most common rheumatic diseases having an identified infectious trigger, the pathogenesis of this arthritis is not well defined. We sought to investigate the host-microbe interactions that contribute to the severity of arthritis initiated by chlamydial infection.Methods. We established an experimental rat model of C trachomatis-induced arthritis that recapitulates many pathologic features of the clinical disease. The severity of the arthritis was defined using an established histopathologic scoring system. Host clearance of the pathogen and local cytokine production were examined by enzyme-linked immunosorbent assays.Results. Lewis rats were susceptible to C trachomatis-induced arthritis, whereas BN rats were relatively resistant to this disease. Significant differences in the histopathologic severity of arthritis were originally observed on day 21, and this prompted an examination of the acute phase of the arthritis. As early as day 5 after the onset of the arthritis, pathologic changes in Lewis rats were more severe than those in BN rats. An evaluation of the role of complement using cobra venom factor treatment excluded complement as being the key to differential sensitivity, because decomplementation did not eliminate the differences in arthritis severity between Lewis and BN rats. Host clearance, in contrast, was significantly different between the rat strains, with BN rats showing more prompt and effective clearance of the pathogen from both synovial tissues and spleen compared with Lewis rats. Local cytokine profiles demonstrated that host resistance was characterized by enhanced synovial expression of tumor necrosis factor ␣, interferon-␥ (IFN␥), and interleukin-4.Conclusion. These studies demonstrated that cytokines thought to be proinflammatory in nature can play an important role in host defense in infectiontriggered arthritis and serve to highlight the dynamic cytokine relationships that constitute effective hostpathogen interactions.

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Section: Host-microbe Interactions In Chlamydia-induced Arthritissupporting

confidence: 81%

Early cytokine profiles in the joint define pathogen clearance and severity of arthritis in Chlamydia‐induced arthritis in rats

Inman

Chiu

2006

Arthritis & Rheumatism

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“…The main driver of M1 polarization is IFN␥, a Th1 cytokine that has been reported to be decreased in SpA synovitis, including HLA-B27ϩ reactive arthritis (27,34). Consistent with this, macrophages derived from the peripheral blood monocytes of AS patients were reported to have an impaired IFN␥ signature as compared with that in healthy controls, which could be restored in vitro by incubation with IFN␥ (35).…”

Section: Discussionmentioning

confidence: 54%

“…In RA, TNF␣ and IL-1␤ are important drivers of bone and cartilage damage (46)(47)(48)(49)(50). Although lower levels of these cytokines in the inflamed SpA joint may contribute to the preservation of tissue integrity, no clear differences in downstream destructive processes have yet been demonstrated between SpA and RA (34,46,51). Alternatively, rather than protecting from tissue destruction, low levels of M1-derived cytokines in SpA may contribute by allowing tissue repair (50,52).…”

Section: Discussionmentioning

confidence: 99%

Absence of a classically activated macrophage cytokine signature in peripheral spondylarthritis, including psoriatic arthritis

Vandooren¹,

Noordenbos²,

Ambarus³

et al. 2009

Arthritis & Rheumatism

154

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Objective. Peripheral spondylarthritis (SpA) is characterized by macrophages that express CD163, a marker of alternative activation (M2). The purpose of this study was to assess whether this differential infiltration with macrophage subsets was associated with a different local inflammatory milieu in SpA as compared with rheumatoid arthritis (RA).Methods Conclusion. The local inflammatory milieu is clearly different in SpA as compared with RA peripheral arthritis. Synovitis in SpA, including that in PsA, is characterized by a selective decrease in M1-derived proinflammatory mediators, such as TNF␣ and IL-1␤.

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“…Bas et al [19] showed that for a subset of ANA ¼ antinuclear antibody; ASCA ¼ anti-Saccharomyces cerevisiae mannan antibodies test; CBC ¼ complete blood count; CRP ¼ C-reactive protein; ESR ¼ erythrocyte sedimentation rate; HLA-B27 ¼ hHHuman leukocyte antigen B27; p-ANCA ¼ perinuclear staining antineutrophil cytoplasmic antibodies; RF ¼ rheumatoid factor; SI ¼ sacroiliac.…”

Section: Pathophysiologymentioning

confidence: 99%

Reactive Arthritis: A Review

Kim

Klausmeier

Orr

2009

Journal of Adolescent Health

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Lower level of synovial fluid interferon-gamma in HLA-B27-positive than in HLA-B27-negative patients with Chlamydia trachomatis reactive arthritis

Abstract: The lower IFN-gamma concentrations in HLA-B27-positive patients with C. trachomatis reactive arthritis could be related to the tendency of these patients to have more severe or chronic arthritis.

Cited by 43 publications

References 0 publications

Early cytokine profiles in the joint define pathogen clearance and severity of arthritis in Chlamydia‐induced arthritis in rats

Early cytokine profiles in the joint define pathogen clearance and severity of arthritis in Chlamydia‐induced arthritis in rats

Absence of a classically activated macrophage cytokine signature in peripheral spondylarthritis, including psoriatic arthritis

Reactive Arthritis: A Review

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