Lower Mean Corpuscular Hemoglobin Concentration is Associated with Favorable Prognosis of Resected Pancreatic Cancer.

Abstract

Objective: This study was designed to explore the value of mean corpuscular hemoglobin concentration (MCHC) for overall survival (OS) in resectable pancreatic cancer (PC). Background: Systemic inflammatory response are important factors that promotes the occurrence and metastasis of malignant tumors. MCHC are suggested to be relevant to the prognosis of several malignancies. Such as lung cancer, head and neck cancers. However, there are few studies to explore the correlation between them and PC. Methods: The present study included totally 544 patients with PC who underwent radical resection between March 2011 and May 2019. These patients were classified into a training set (n=195) and a validation set (n=349). Kaplan-Meier curve method and Cox proportional hazard regression model were employed to analyze prognosis. Results: Survival curve showed that OS were significantly favorable for resectable PC patients with low preoperative MCHC (P=0.015). Multivariate analysis suggested that MCHC (hazard ratio [HR], 1.266; 95% confidential interval [CI], 0.895-1.792; P=0.028) were independent prognostic factors for resectable PC patients. Conclusion: Low MCHC was positively correlated with OS in resectable PC, which could be used to predict the prognosis.