Lower Omega-3 Index Is a Marker of Increased Propensity of Hypertensive Rat Heart to Malignant Arrhythmias

Bačová, Barbara Szeiffová; Sec, Peter; Radošinská, Jana; Čertı́k, Milan; Vachulova, A.; Tribulová, Narcis

doi:10.33549/physiolres.932626

Cited by 7 publications

(1 citation statement)

References 25 publications

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“…A recent noteworthy study showed that β1-adrenoceptor autoantibody suppression is involved in the antiarrhythmic effects of omega-3 FA in male and female rats with essential hypertension [224]. The older rats in this strain exhibited lower omega-3 index than the normotensive controls [225]. Their antiarrhythmic effect was also demonstrated in the treatment of sympathetic over-drive in normotensive and hypertensive rats [226], and its supplementation in obese older female rats resulted in reduced heart susceptibility to VT and VF [227].…”

Section: Antiarrhythmic Efficacy Of Omega-3 Fatty Acidsmentioning

confidence: 99%

Mechanisms Underlying Antiarrhythmic Properties of Cardioprotective Agents Impacting Inflammation and Oxidative Stress

Andelová

Bacova

Sýkora

et al. 2022

IJMS

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The prevention of cardiac life-threatening ventricular fibrillation and stroke-provoking atrial fibrillation remains a serious global clinical issue, with ongoing need for novel approaches. Numerous experimental and clinical studies suggest that oxidative stress and inflammation are deleterious to cardiovascular health, and can increase heart susceptibility to arrhythmias. It is quite interesting, however, that various cardio-protective compounds with antiarrhythmic properties are potent anti-oxidative and anti-inflammatory agents. These most likely target the pro-arrhythmia primary mechanisms. This review and literature-based analysis presents a realistic view of antiarrhythmic efficacy and the molecular mechanisms of current pharmaceuticals in clinical use. These include the sodium‑glucose cotransporter-2 inhibitors used in diabetes treatment, statins in dyslipidemia and naturally protective omega-3 fatty acids. This approach supports the hypothesis that prevention or attenuation of oxidative and inflammatory stress can abolish pro-arrhythmic factors and the development of an arrhythmia substrate. This could prove a powerful tool of reducing cardiac arrhythmia burden.

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Section: Antiarrhythmic Efficacy Of Omega-3 Fatty Acidsmentioning

confidence: 99%

Mechanisms Underlying Antiarrhythmic Properties of Cardioprotective Agents Impacting Inflammation and Oxidative Stress

Andelová

Bacova

Sýkora

et al. 2022

IJMS

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About the controversies of the cardioprotective effect of n-3 polyunsaturated fatty acids (PUFAs) between animal studies and clinical meta-analyses: a review with several strategies to enhance the beneficial effects of n-3 PUFAs

Demaison

Leger

Vergely³

et al. 2019

J Physiol Biochem

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Differences between α-linolenic and linoleic acid supplementation on the redox status and cardiodynamic parameters of male and female Wistar albino rats

Radoman

Živković²,

Nikolić³

et al. 2018

ARCH BIOL SCI BELGRA

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The aim of present study was to investigate the difference between α-linolenic acid (ALA, omega-3) and linoleic acid (LA, n-6) on the redox status and cardiac function of the isolated rat heart. ALA or LA were administered for 6 weeks by gavage to all animals, which were randomly divided into 4 groups: male rats treated with a linoleic acid (M-LA), dose of 7.3 mg/kg/day; female rats treated with a linoleic acid (F-LA), dose of 7.3 mg/kg/day; male rats treated with an α-linolenic acid (M-ALA), dose of 165 mg/kg/day; female rats treated with α-linolenic acid (F-ALA), dose of 165 mg/kg/day. Using the Langendorff technique, markers of heart function were evaluated: the maximum and minimum rates of pressure development in the left ventricle (LV; dp/dt max, dp/dt min), systolic and diastolic left ventricle pressure (SLVP, DLVP, respectively), heart rate (HR) and coronary flow (CF). We measured the concentrations of prooxidative markers: nitrites (NO 2-), superoxide anion radicals (O 2-) and hydrogen peroxide (H 2 O 2), as well as the index of lipid peroxidation (TBARS) in the plasma and effluent. In the lysate, we measured the concentrations of reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD). ALA more negatively influenced the isolated rat heart, especially in females. In contrast, the administration of LA was linked to more prominent oxidative stress, while the application of ALA was associated with improved activity of the antioxidative defense system (with better values in males).

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Lower Omega-3 Index Is a Marker of Increased Propensity of Hypertensive Rat Heart to Malignant Arrhythmias

Cited by 7 publications

References 25 publications

Mechanisms Underlying Antiarrhythmic Properties of Cardioprotective Agents Impacting Inflammation and Oxidative Stress

Mechanisms Underlying Antiarrhythmic Properties of Cardioprotective Agents Impacting Inflammation and Oxidative Stress

About the controversies of the cardioprotective effect of n-3 polyunsaturated fatty acids (PUFAs) between animal studies and clinical meta-analyses: a review with several strategies to enhance the beneficial effects of n-3 PUFAs

Differences between α-linolenic and linoleic acid supplementation on the redox status and cardiodynamic parameters of male and female Wistar albino rats

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