2021
DOI: 10.1371/journal.pone.0257176
|View full text |Cite
|
Sign up to set email alerts
|

Lower p66Shc promoter methylation in subjects with chronic renal failure

Abstract: Objective To determine the correlation between DNA methylation of p66Shc promoter and some markers of inflammatory and oxidative stress in chronic renal failure (CRF) patients compared with healthy subjects. Methods An observational cross-sectional study was conducted in the nephrology department at Sidi Bouzid Regional Hospital (Tunisia). In total, 39 patients with CRF and 37 healthy subjects were included. Several biochemical parameters were measured. Furthermore, markers of the oxidative and inflammatory … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(2 citation statements)
references
References 47 publications
0
2
0
Order By: Relevance
“…It has been demonstrated that p66Shc expression is significantly higher in at least some cell types of diabetic patients, including peripheral mononuclear cells, renal cortex, and aorta. Similarly, increase in expression of p66Shc was seen in serum and placenta of patients with gestational diabetes mellitus [4,[25][26][27][28][29]. Also, high glucose and diabetes mellitus can increase p66Shc expression [4,30].…”
Section: The Molecular Role Of P66shc In Diabetesmentioning
confidence: 84%
See 1 more Smart Citation
“…It has been demonstrated that p66Shc expression is significantly higher in at least some cell types of diabetic patients, including peripheral mononuclear cells, renal cortex, and aorta. Similarly, increase in expression of p66Shc was seen in serum and placenta of patients with gestational diabetes mellitus [4,[25][26][27][28][29]. Also, high glucose and diabetes mellitus can increase p66Shc expression [4,30].…”
Section: The Molecular Role Of P66shc In Diabetesmentioning
confidence: 84%
“…Diabetes is one of the most important causes of end stage renal diseases. It has been shown that p66Shc expression increases in renal tissue of patients with diabetic nephropathy, and epigenetic changes in its promoter were observed in patients with diabetic nephropathy [ 27 ]. p66Shc-negative diabetic mice show significantly better renal function and structure compared to wild-type mice.…”
Section: Effects Of P66shc On Diabetes-related Complicationsmentioning
confidence: 99%