Lower prevalence of hypercholesterolemia and hyperglyceridemia found in subjects with seropositivity for both Hepatitis B and C strains independently

Chen, Jingyi; Wang, Jing‐Houng; Lin, Chih-Min; Chen, Pao-Fei; Tseng, Po‐Lin; Chen, Chien‐Hung; Chang, Kuo‐Chin; Tsai, Lin-San; Chen, Shu‐Chuan; Lu, Sheng–Nan

doi:10.1111/j.1440-1746.2010.06300.x

Cited by 53 publications

(56 citation statements)

References 36 publications

(83 reference statements)

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“…Chronic HBV infection is associated with lower prevalence of hypertriglyceridemia in men and women (Jan et al 2006;Chen et al 2010;Wong et al 2012;Chung et al 2014;Huang et al 2016). In this study, however, OBI was detected at higher frequency in HLP patients than in replacement blood donor population controls (9.5% vs. 2.4%, P < 0.001), which suggested a positive association between OBI and HLP.…”

Section: Discussioncontrasting

confidence: 47%

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Occult Hepatitis B Virus Infection in Hyperlipidemia Patients

Yang

Li²,

Li³

et al. 2017

Tohoku J. Exp. Med.

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Chronic hepatitis B virus (HBV) infection is associated with lower prevalence of hyperlipidemia (HLP).However, occult HBV infection (OBI) in HLP patients has not yet been explored. OBI is defined as the presence of detectable HBV DNA in serum or liver tissue but undetectable HBV surface antigen in serum. In this study, 1,036 HLP patients and 1,134 replacement blood donor controls were recruited. Among them, 252 HLP patients and 255 blood donors with antibody to HBV core positive were selected and analyzed. HBV DNA was confirmed by nucleic acid testing assays, and nucleotide mutations were analyzed. OBI was detected in 9.5% (24/252) of HLP patients and 2.4% (6/255) of blood donors, respectively (P < 0.001). In HLP population, 41.7% of OBI and 13.6% of non-OBI carriers were associated with daily alcohol consuming > 30 g/day (P < 0.01), while in control population those rates were not statistically different between OBI and non-OBI carriers (P > 0.05). Viral load of OBI in HLP patients was higher than that of OBI in blood donors (P < 0.05), which was a positive correlation between total cholesterol and HBV viral load levels (r = 0.474 P = 0.019). HBV vaccination rate was found significantly lower in OBI HLP patients than that in non-OBI HLP patients (P < 0.01). Importantly, mutations were found in basic core promoter region of HBV among OBI HLP patients. In conclusion, the frequency of OBI is significantly higher in HLP patients, especially those patients with heavy daily alcohol consumption.

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Section: Discussioncontrasting

confidence: 47%

“…Previous studies showed that chronic hepatitis B virus (HBV) infection was associated with lower prevalence of hypertriglyceridemia (Jan et al 2006;Chen et al 2010;Wong et al 2012;Chung et al 2014;Huang et al 2016) or hypercholesterolemia (Chen et al 2010;Liu et al 2013). …”

Section: Introductionmentioning

confidence: 99%

Occult Hepatitis B Virus Infection in Hyperlipidemia Patients

Yang

Li²,

Li³

et al. 2017

Tohoku J. Exp. Med.

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“…In other words, whether these studies [36–41, 44–47] meet the MetS criteria (Q4: The MetS and its components were defined accurately) did not affect the statistical results (SMD), so they were labeled with “UR” (unrelated) for Q4 in Table 3. The remaining 20 studies [10–17, 26–35, 42, 43] reported ORs or crude data for calculating the ORs. The MetS criteria used in these 20 studies was similar, but not identical.…”

Section: Resultsmentioning

confidence: 99%

“…For “Elevated TG”, the pooled OR was from 14 studies [10–16, 26, 28, 30, 31, 33–35], and the SMD was from 14 studies [10, 16, 17, 26, 31, 34, 36, 37, 39, 42, 44–47]. They are not identical.…”

Section: Resultsmentioning

confidence: 99%

Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysis

Li¹,

Zhao²,

Wu³

2017

PLoS ONE

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Background and aimAs there is conflicting evidence for the relationship between hepatitis B virus surface antigen (HBsAg) positivity and the prevalence of metabolic syndrome (MetS), we performed a meta-analysis to investigate whether HBsAg positivity affects the incidence of MetS.MethodsObservational studies on the relationship between HBsAg positivity and MetS were obtained from PubMed, Web of Science, and the Cochrane Library in April 2016. The pooled odds ratios (ORs) of MetS and its components (central obesity, increased fasting glucose, increased blood pressure, dyslipidemia) for subjects with or without HBsAg positivity were synthesized. The standardized mean difference of MetS components between HBsAg-positive participants and healthy controls was calculated. Heterogeneity was explored with subgroup analysis and sensitivity analysis. Publication bias was detected using Egger’s test and Begg’s test.ResultsThirty studies were eligible for meta-analysis. The MetS OR for HBsAg-positive participants was significantly decreased compared with the controls [OR = 0.80, 95% confidence interval (CI), 0.70–0.90]. The negative effect of HBsAg positivity on elevated triglycerides (OR = 0.62, 95% CI, 0.59–0.64) was strong, while that for increased fasting blood glucose was weak (OR = 0.94, 95% CI, 0.90–0.98). The pooled ORs of central obesity (OR = 0.97, 95% CI, 0.91–1.04), reduced high-density lipoprotein cholesterol (OR = 0.98, 95% CI, 0.83–1.14), and elevated blood pressure (OR = 1.00, 95% CI, 0.80–1.25) for HBsAg-positive participants were all not significantly different compared with the controls. No publication bias was detected.ConclusionsSerum HBsAg positivity is inversely associated with the prevalence of MetS. Among the five components of MetS, elevated triglycerides had the strongest inverse relationship with HBsAg positivity.

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“…Generally the redox species in the iodide/tri-iodide solution ensure holes enable transport from the oxidized dye to the counter electrode to close the redox cycle. However with a cracked film the conducting substrate intended to come into contact with oxidizing species in the electrolyte which enhance the recombination probability and in turn reduce the efficiency of the solar cell [14]. Conversely, the cracks connection will promote the formation of large dense domains which favor light scattering and harvesting.…”

Section: Protocol )mentioning

confidence: 99%

Effect of cracking and aggregation on the efficiency of DSSC

Taleb

Mesguish

Xue

2014

2014 International Renewable and Sustainable Energy Conference (IRSEC)

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Different synthesis protocols have been developed to control TiOz anatase nanoparticIe aggregation and cracks formation within the film formed by this nanoparticIe. The diameter of TiOz packing aggregate varies from 13nm to lOOnm. Efficiency of dye-sensitized solar cells (DSSC) fabricated with the obtained TiOz packing aggregate films was reported to depend on the size of the packing aggregate and cracks formation. This effect was discussed in terms of a balance between adsorbing amount of dye molecules, cracks free and the efficiency of electron transfer.

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Lower prevalence of hypercholesterolemia and hyperglyceridemia found in subjects with seropositivity for both Hepatitis B and C strains independently

Abstract: This large scale community-based study demonstrated that subjects with seropositivity for Hepatitis C not only had lower prevalence of hypercholesterolemia and hypertriglyceridemia but subjects with seropositivity for Hepatitis B had the same trend.

Cited by 53 publications

References 36 publications

Occult Hepatitis B Virus Infection in Hyperlipidemia Patients

Occult Hepatitis B Virus Infection in Hyperlipidemia Patients

Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysis

Effect of cracking and aggregation on the efficiency of DSSC

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