Lower risk of atopic dermatitis among infants born extremely preterm compared with higher gestational age

Abstract

Very low GA (< 29 weeks) was associated with a lower risk of AD compared with higher GA (29-34 weeks) and full-term birth.

8th Georg Rajka International Symposium on Atopic Dermatitis: meeting report

“…Dr S ebastien Barbarot interrogated two large French birth cohorts to investigate the effect of prematurity on AD risk. 12 Contrary to the hypothesis that extreme prematurity increases risk due to an impaired skin barrier, those with a gestational age < 29 weeks had a 50% lower risk. Possible mechanisms include shorter exposure to T helper (Th)2 cytokines during pregnancy or induction of tolerance through the impaired skin barrier.…”

“…Other studies examined the influence of early‐life events. Dr Sébastien Barbarot interrogated two large French birth cohorts to investigate the effect of prematurity on AD risk . Contrary to the hypothesis that extreme prematurity increases risk due to an impaired skin barrier, those with a gestational age < 29 weeks had a 50% lower risk.…”

Le soin de la peau du nouveau-né prématuré : un enjeu commun aux dermatologues et aux néonatalogistes

“…D'un point de vue dermatologique, l'amélioration de la survie de ces enfants a permis de mieux décrire des dermatoses d'origine infectieuse comme la dermite invasive à Candida albicans [4] et de montrer que la grande prématurité réduit le risque de déve-lopper une dermatite atopique de 50 % par des mécanismes mal compris, dans lesquels interviennent peut-être l'immaturité de la barrière cutanée et du système immunitaire avant 29 SA [5].…”

Asthma and atopic dermatitis after early‐, late‐, and post‐term birth

“…Children born prematurely appear to carry an increased risk of asthma and/or asthma‐like symptoms in childhood, whereas their risk of atopic dermatitis has been found to be decreased compared with children born at a later gestational age (GA).…”

“…cesarean section, hospital admission, reimbursement, risk factor, tobacco smoke exposure 1 | INTRODUCTION Children born prematurely appear to carry an increased risk of asthma and/or asthma-like symptoms in childhood, [1][2][3] whereas their risk of atopic dermatitis has been found to be decreased [3][4][5] compared with children born at a later gestational age (GA).…”