Lower serum levels of Meteorin-like/Subfatin in patients with coronary artery disease and type 2 diabetes mellitus are negatively associated with insulin resistance and inflammatory cytokines

Dadmanesh, Maryam; Aghajani, Hassan; Fadaei, Reza; Ghorban, Khodayar

doi:10.1371/journal.pone.0204180

Cited by 57 publications

(54 citation statements)

References 30 publications

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“…The low serum levels of Metrnl in patients diagnosed with PCOS showed an independent association with the pathogenesis of the disease, partly through insulin resistance, as evidenced by the correlation between Metrnl levels and glucose homeostasis parameters. Similar correlation was observed in several studies [35][36][37]. For instance, Wang et al found that Metrnl levels positively correlated with FBG, post-prandial BG, HbA1c, fasting insulin, and HOMA-IR.…”

Section: Plos Onesupporting

confidence: 85%

“…Furthermore, a strong inverse correlation was detected between serum Metrnl and hs-CRP levels in the PCOS group and subgroups. The same association was detected by Dadmanesh et al [36], and Li et al [73], in the context of T2DM and CAD. El-Ashmawy et al also found a negative correlation between serum Metrnl and hs-CRP levels, IL-6, TNF-α, and endothelial dysfunction markers (E-selectin and intracellular adhesion molecule-1) in DM patients.…”

Section: Plos Onesupporting

confidence: 79%

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Circulating levels of Meteorin-like protein in polycystic ovary syndrome: A case-control study

et al. 2020

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Patients diagnosed with polycystic ovary syndrome (PCOS) are at high risk of developing a myriad of endocrinologic and metabolic derailments. Moreover, PCOS is a leading cause of habitual abortion, also known as recurrent pregnancy loss (RPL). Meteorin-like protein (Metrnl) is a newly discovered adipokine with the potential to counteract the metaflammation. This study aimed at determining the associations of serum Metrnl levels with homocysteine, hs-CRP, and some components of metabolic syndrome in PCOS-RPL and infertile PCOS patients.This case-control study was conducted in 120 PCOS patients (60 PCOS-RPL and 60 infertile) and 60 control. Serum hs-CRP and homocysteine were assessed using commercial kits, while adiponectin, Metrnl, FSH, LH, free testosterone and insulin levels were analyzed using ELISA technique. Serum Metrnl levels were found to be lower in PCOS patients when compared to controls (67.98 ± 26.66 vs. 96.47 ± 28.72 pg/mL, P <0.001)). Furthermore, serum adiponectin levels were lower, while free testosterone, fasting insulin, HOMA-IR, homocysteine, and hs-CRP were significantly higher in PCOS group compared to controls. Moreover, serum Metrnl correlated with BMI, adiponectin, and homocysteine in controls, and inversely correlated with FBG, fasting insulin, and HOMA-IR in PCOS group and subgroups. Besides, it inversely correlated with hs-CRP in control, and PCOS group and subgroups. These findings revealed a possible role of Metrnl in the pathogenesis of PCOS and RPL. Nevertheless, there is a necessity for future studies to prove this concept.

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Section: Plos Onesupporting

confidence: 85%

Section: Plos Onesupporting

confidence: 79%

Circulating levels of Meteorin-like protein in polycystic ovary syndrome: A case-control study

et al. 2020

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“…96 A study by Lee et al demonstrated lower levels of MERNTL in newly diagnosed patients with T2DM and pre-diabetes subjects in comparison to controls. 96 However, there are some conflicting data regarding the expression levels of METRNL in those with T2DM and obesity. 96 However, there are some conflicting data regarding the expression levels of METRNL in those with T2DM and obesity.…”

Section: Meteorin-like (Metrnl)mentioning

confidence: 98%

“…94,95 Moreover, it has been reported that the circulating levels of METRNL are lower in obese patients. 96 A study by Lee et al demonstrated lower levels of MERNTL in newly diagnosed patients with T2DM and pre-diabetes subjects in comparison to controls. 97 A similar observation was reported in patients with T2DM as well as its association with the parameters of glucose and lipid metabolism and markers of the endothelial function.…”

Section: Meteorin-like (Metrnl)mentioning

confidence: 98%

“…97 A similar observation was reported in patients with T2DM as well as its association with the parameters of glucose and lipid metabolism and markers of the endothelial function. 96 However, there are some conflicting data regarding the expression levels of METRNL in those with T2DM and obesity. One group has reported elevated levels of METRNL in individuals with T2DM compared to non-diabetic controls while another group has shown that METRNL expression in the adipose tissue is higher in obese children in comparison to lean children.…”

Section: Meteorin-like (Metrnl)mentioning

confidence: 99%

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Myokines in skeletal muscle physiology and metabolism: Recent advances and future perspectives

2019

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Myokines are molecules produced and secreted by skeletal muscle to act in an auto-, para-and endocrine manner to alter physiological function of target tissues. The growing number of effects of myokines on metabolism of distant tissues provides a compelling case for crosstalk between skeletal muscle and other tissues and organs to regulate metabolic homoeostasis. In this review, we summarize and discuss the current knowledge regarding the impact on metabolism of several canonical and recently identified myokines. We focus specifically on myostatin, β-aminoisobutyric acid, interleukin-15, meteorin-like and myonectin, and discuss how these myokines are induced and regulated as well as their overall function. We also review how these myokines may serve as potential prognostic biomarkers that reflect whole-body metabolism and how they may be attractive therapeutic targets for treating muscle and metabolic diseases. K E Y W O R D Sinterleukin-15, metabolism, meteorin-like, myonectin, myostatin, β-aminoisobutyric acid

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Serum Meteorin‐like is associated with weight loss in the elderly patients with chronic heart failure

Cai

Wang

et al. 2021

J cachexia sarcopenia muscle

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Background Unintentional weight loss (cachexia) has been associated with poor outcomes in chronic heart failure (CHF). Meteorin‐like (Metrnl) is a novel myokine with protective effects on cardiovascular diseases. However, the change of Metrnl concentrations and its role in elderly patients with CHF remains unclear. The aim of this study was to evaluate the association of serum Metrnl with weight loss and outcomes in elderly patients with CHF. Methods A total of 931 consecutive elderly patients (aged 60 years and older) with CHF and 135 age‐matched and sex‐matched control subjects were enrolled. Serum Metrnl concentration was measured by enzyme‐linked immunosorbent assay. Body weight was measured at baseline and 12 months. Results Median of serum Metrnl levels was lower in CHF patients when compared with controls [201.31 (184.95–261.16) pg/mL vs. 168.68 (103.15–197.54) pg/mL, P < 0.001]. Patients with the lowest levels of Metrnl had higher N‐terminal pro brain natriuretic peptide (NT‐proBNP) levels but lower left ventricular eject fraction (LVEF) and estimated glomerular filtration rate (P < 0.001). Lower serum Metrnl was associated with a higher risk of >5% weight loss from baseline to 12 months [odds ratio = 6.13, 95% confidence interval (CI) = 2.57–14.62 per log decrease; P < 0.001]. Serum Metrnl levels were decreased as LVEF decreased (P < 0.001) and were positively correlated with LVEF (r = 0.267, P < 0.001) but negatively correlated with NT‐proBNP levels (r = −0.257, P < 0.001). Cox regression analysis suggested that lower serum Metrnl was associated with higher cardiovascular mortality [hazard ratio (HR) = 6.71, 95% CI = 3.41–13.18 per log decrease; P < 0.001], CHF rehospitalization (HR = 3.07, 95% CI = 1.82–5.17 per log decrease; P < 0.001), and the combined major adverse cardiac event(s) (MACEs) (HR = 5.38, 95% CI = 3.51–8.25 per log decrease; P < 0.001). The Kaplan–Meier survival curves showed that low concentration of Metrnl was a prognostic indicator of MACEs in patients with CHF. Conclusions Our study suggests that lower serum Metrnl level is correlated with weight loss and the severity of cardiac dysfunction in elderly patients with CHF.

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Lower serum levels of Meteorin-like/Subfatin in patients with coronary artery disease and type 2 diabetes mellitus are negatively associated with insulin resistance and inflammatory cytokines

Cited by 57 publications

References 30 publications

Circulating levels of Meteorin-like protein in polycystic ovary syndrome: A case-control study

Circulating levels of Meteorin-like protein in polycystic ovary syndrome: A case-control study

Myokines in skeletal muscle physiology and metabolism: Recent advances and future perspectives

Serum Meteorin‐like is associated with weight loss in the elderly patients with chronic heart failure

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