Lower serum zinc in major depression in relation to changes in serum acute phase proteins.

Maes, Michaël; Vos, Nathalie De; Demedts, Paul; Wauters, Annick; Neels, Hugo

doi:10.1016/s0165-0327(99)00011-7

Cited by 125 publications

(75 citation statements)

References 26 publications

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“…It was found that patients suffering from depression exhibit increased inflammatory cytokines, such as IL-6, which positively correlated with plasma cortisol [25]. Despite the decreased cortisol/corticosterone level after antidepressants, we received opposite results under zinc deficient conditions in our study, and this may result from the elevated IL-6 observed in zinc deficiency [23]. According to Pennix et al [39], these direct effects may lead to neurochemical and behavioral changes that may induce depression.…”

Section: Zinc Deficiency Alters Responsiveness To Antidepressantsmentioning

confidence: 49%

Zinc deficiency alters responsiveness to antidepressant drugs in mice

Młyniec

Budziszewska

Reczyński

et al. 2013

Pharmacological Reports

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Abstract:Background: There is some evidence coming from preclinical and clinical studies suggesting a relationship between dietary zinc intake and depressive symptoms. The aim of the study was to determine whether zinc deficiency alters the response to antidepressants with a different mechanism of action. We examine also whether these changes are related to activity of the hypothalamic-pituitaryadrenal HPA axis. Methods: Male CD-1 mice were assigned to groups according to diet and antidepressant administration. To evaluate animal behavior, the immobility time in the forced swim test (FST) and locomotor activity were measured. To determine serum zinc levels the flame atomic absorption spectroscopy (FAAS) was used. The serum corticosterone was determined by radioimmunoassay (RIA). Results: Antidepressants administered to zinc-deprived mice induced an altered response in the FST when compared to animals fed with an adequate diet. There were no changes in locomotor activity. Animals subjected to a zinc-deficient diet showed a significant reduction in serum zinc levels, which was normalized by antidepressant treatment. An increase in serum corticosterone concentrations in mice fed with a zinc-deficient diet and treated with antidepressants was observed, so it can be concluded that reduced levels of zinc contribute hyperactivation of the HPA axis. Conclusion:The results of this study suggest that a diet with a reduced zinc level alters antidepressant action, which is associated with a reduction in the serum zinc level and rise in the corticosterone level. The results of this study may indicate the involvement of zinc deficiency in the pathogenesis of depression.

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Section: Zinc Deficiency Alters Responsiveness To Antidepressantsmentioning

confidence: 49%

Zinc deficiency alters responsiveness to antidepressant drugs in mice

Młyniec

Budziszewska

Reczyński

et al. 2013

Pharmacological Reports

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“…Studies of clinically depressed (18)(19)(20)(21)(22)(23)(24) and healthy (27,28) groups have suggested a link between zinc status and psychological well-being. Given evidence to suggest that for a multiplicity of reasons, ageing can be associated with zinc depletion (31) , it was hypothesised that supplemented zinc would enhance mood in older people.…”

Section: Discussionmentioning

confidence: 99%

Supplemented zinc does not alter mood in healthy older European adults – a randomised placebo-controlled trial: the Zenith study

Stewart-Knox

Rae

Simpson

et al. 2011

Public Health Nutr.

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Objective: Older people are vulnerable to zinc deficiency, which may impact upon their mood. This randomised, placebo-controlled, double-blind intervention study aimed to investigate the effect of oral zinc gluconate supplementation (15 mg/d; 30 mg/d; and placebo) on subjective mood (affect) in older Europeans. Subjects: Healthy volunteers (n 387) aged 55-87 years were recruited. Setting: Volunteers in Rome (Italy; n 108) and Grenoble (France; n 91) were aged 70-87 years and those in Coleraine (Northern Ireland; n 93) and Clermont-Ferrand (France; n 95) were aged 55-70 years. Design: Mood was measured using the Positive and Negative Affect Scale on four occasions per day over 4 d at baseline, 3 and 6 months post-intervention. Results: Mixed ANOVA indicated that neither positive nor negative affect altered in response to zinc (15 mg/d or 30 mg/d) compared to placebo in either the 55-70 years or the $70 years age group. Conclusions: These results suggest that zinc does not benefit mood in healthy older people.

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“…Recently, clinical data have revealed lower serum zinc concentration in depressed patients (39,40). Clinical studies have shown zinc supplementation to be beneficial in the antidepressant therapy of depressed patients (41).…”

Section: Zinc Ion Bindingmentioning

confidence: 99%

Gene Expression Profiling Reveals Complex Changes in the Olfactory Bulbectomy Model of Depression After Chronic Treatment With Antidepressants

et al. 2008

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Abstract. We investigated the effects of antidepressants on the gene expression profile and behavior of olfactory-bulbectomized (OBX) rats. Removal of the main olfactory bulbs in rats alters neuronal function in brain areas involved in emotional regulation, resulting in maladaptive behavioral patterns similar to the symptoms of patients with depression. Previously, we found that OBX-induced behavioral and neuronal abnormalities were completely rescued by chronic treatment with SNC80, an opioid delta agonist, as well as with classical monoaminergic antidepressants. Thus, to determine the basis for this effect, we analyzed gene expression in OBX rat frontal cortex using a GeneChip ® rat Genome oligonucleotide array after imipramine or SNC80 treatment. We found that imipramine and SNC80 induced the following systematic changes in OBX rats: zinc ion binding; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; protein serine / threonine kinase activity; N-acetyltransferase activity; protein modification process; regulation of cellular process; and regulation of neurotransmitter levels. Defining the roles of candidate neuronal systems in antidepressant-induced neural changes are likely to transform the course of research on the biological basis of mood disorders.

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Lower serum zinc in major depression in relation to changes in serum acute phase proteins.

Cited by 125 publications

References 26 publications

Zinc deficiency alters responsiveness to antidepressant drugs in mice

Zinc deficiency alters responsiveness to antidepressant drugs in mice

Supplemented zinc does not alter mood in healthy older European adults – a randomised placebo-controlled trial: the Zenith study

Gene Expression Profiling Reveals Complex Changes in the Olfactory Bulbectomy Model of Depression After Chronic Treatment With Antidepressants

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