Lower Uric Acid Levels in Subjects Consuming Coffee compared to Not Consuming Coffee

Abstract

Uric acid as the nitrogen compounds produced from catabolism purine from both diet and endogenous nucleic acids (DNA deoxyribonucleic acid). One of the factors that can increase uric acid levels is the factor of excessive purine intake. The habit of consuming coffee can reduce levels of uric acid because the content of polyphenol compounds in coffee such as chlorogenic acid can inhibit the activity of the enzyme xanthine oxidase, thereby reducing levels of uric acid. The purpose of study was to determine differences in uric acid levels between subjects who consumed coffee and did not consume coffee in the Eastern Puskesmas area in 2018. This study included an analytical study with research design cross-sectional. The number of study subjects was 46 subjects aged 45-54 years. Spectrophotometer Rayto measured the level of uric acid in the blood, data on the history of gout and consumption habits were obtained using an observation sheet. Data analysis used test Mann-Whitney. There were differences in uric acid levels between subjects who consumed coffee and did not consume coffee in the East Rim Health Center area in 2018, the uric acid level of subjects who consumed coffee was lower than subjects who did not consume coffee (CI 95% 6.20, 7.80 ; p =0.001). Uric acid levels of subjects who consume coffee are lower than subjects who do not consume coffee, and coffee can be used as a non-pharmacological alternative treatment and prevention of Gout.

Analysis Of Uric Acid Levels In Pre-Elderly Patients In Terms Of Coffee Drinking Behavior In The Work Area Of The Cikeusal Health Center, Serang Regency In 2022

“…Based on statistical analysis, the results of the Anova One Way test were obtained, namely the p value (0.000) which is smaller than the α value (0.05), so it shows that there is a significant influence between coffee drinking habits on the uric acid levels of men aged 45-65 years. Sunita et al (2019) there was a difference in uric acid levels between subjects who consumed coffee and did not consume coffee, uric acid levels of subjects who consumed coffee were lower than subjects who did not consume coffee (CI 95% 6.20, 7.80; p = 0.001). The uric acid levels of subjects who consumed coffee were lower than those subjects who did not consume coffee.…”

“…Coffee, one of the drinks that is known to be low in purines is one of the most popular drinks in Indonesia (Utami, 2019). Coffee consumption has a positive effect on the body can reduce uric acid levels because coffee contains polyphenol compounds (Chlorogenic Acid) which can inhibit the work of xanthine oxidase (Sunita, 2019).…”

“…The content of coffee (polyphenols) that has been identified as an antioxidant is chlorogenic acid (Welkriana, et al, 2018). This compound is able to inhibit the work of xanthin oxidase, if the work of the xanthin oxidase enzyme is inhibited, the formation of uric acid in the body will decrease (Sunita, et al, 2019). Coffee also has negative effects, including disrupting iron absorption, causing iron deficiency anemia, peptic ulcer, erosive esophagitis, and gastroesophageal reflux (Dewajanti, 2019).…”