Background: One of skin diseases that is frequently taking attention among teenagers and young adults is acne or in medical term called acne vulgaris. Acne treatment can be treated by repairing follicular abnormalities, decreasing sebum production, decreasing the number of Propionibacterium acnes colonies and reducing inflammation of the skin. The bacterial population of Propionibacterium acnes can be reduced by giving an antibacterial substance such as erythromycin, clindamycin and benzoyl peroxide. In the treatment of acne we can get antibacterial originating from nature, one of which can be obtained in the secondary metabolism of plants. The extracts and essential oils of betel leaf contain antibacterial and antifungal activities. The effectiveness of the use of betel leaf ethanol extract (Piper betle Linn) in acne treatment can be improved by creating formulations in form of cream preparations. Formulations in cream preparations will affect the amount and speed of active substances that can be absorbed. Objectives: To determine the effectiveness of the ethanol extract cream of betel leaf (piper betle linn) cream in formulas with what percentage of active substance has the most-inhibitory effect on the growth of Propionibacterium acnes. Methods:The study used experimental research. Propionibacterium acnes samples were diluted in 0.9% physiological NaCl sterile and embedded in Nutrient Agar (NA) media. The media was inserted into an incubator at 37 ° C for 24 hours. The test of antibacterial activity used the disk diffusion method. The antibacterial activity test results were statistically analyzed using the Statistical Product Services Solution (SPSS 17) program with a confidence level of 95% (α = 0.05). Results: The three creams containing betel leaf ethanol extracts at percentages of 5%, 10% and 15% for each had inhibitory zones: 9.8 mm, 15.85 mm, 17.35 mm. Conclusion: Cream that contains 15% active substance has the strongest inhibition.

Latar belakang: Singkong (Manihot utilissima Pohl.) adalah salah satu tanaman yang bagian daunnya sering dimanfaatkan sebagai obat oleh masyarakat. Beberapa penelitian telah membuktikan bahwa kandungan flavonoid ekstrak daun singkong memiliki aktivitas antibakteri terhadap bakteri gram positif maupun bakteri gram negatif. Sediaan farmasi yang dapat digunakan untuk menjaga kesehatan khususnya kulit adalah sabun cair. Sabun cair lebih higienis dan lebih praktis dibawa kemana-mana serta harus memenuhi syarat uji karakteristik SNI. Tujuan: Penelitian ini bertujuan untuk mengetahui formula sabun cair dari ekstrak etanol daun singkong (Manihot utilissima Pohl.) yang memenuhi karakteristik sediaan sabun cair. Metode:Penelitian menggunakan metode eksperimental untuk meneliti karakteristik sediaan sabun cair dengan konsentrasi ekstrak daun singkong 0%, 2%, 3% dan 4% yang meliputi uji organoleptis, homogenitas, pH, tinggi busa dan iritasi. Hasil: Hasil uji sediaan sabun cair pada formula I (2%), formula II (3%), dan formula III (4%) telah memenuhi syarat uji organoleptis, homogenitas, pH, tinggi busa yang ditetapkan oleh SNI serta tidak menyebakan iritasi pada kulit. Kesimpulan: Penelitian yang telah dilakukan menunjukkan bahwa daun singkong dapat diformulasikan menjadi sabun cair karena pada konsentrasi 2%, 3% dan 4% telah memenuhi syarat uji karakteristik. Saran: Perlu dilakukan penelitian lebih lanjut dengan alat pengaduk canggih, variasi konsentrasi ekstrak dibawah 2% dan konsentrasi CMC dibawah 1%. Selain itu, perlu dilakukan uji viskositas dan uji aktivitas antibakteri untuk mengetahui karakteristik dan efektivitas antibakteri.  

Infection is a disease that causes tissue damage. One cause of skin infections is bacteria Staphylococcus aureus. Utilization of natural materials as traditional medicine in Indonesia is now increasing. Centella Asiatica is one of the nutritious plants for medicine, contains active antibacterial components such as saponin or asiatikosida, alkaloid, flavonoids, and tannins. Saponins or asiaticocides are lipophilic which can form complex compounds with cell membranes through hydrogen bonds, then destroy the permeability of bacterial cell walls. This research is to test the effectivity of antimicrobial substances contained in the extract of Leaf kola leaf infusion as a traditional medicine to the growth of Staphylococcus aureus, with the descriptive survey design method to find out the effectiveness of Inca leaf infusion extract zone (Centella Asiatica L) to bacteria Staphylococcus aureus. Result: The concentration formed inhibition zone of bacterial growth Staphylococcus aureus is 25% concentration average 7.25 mm, 50% average 11.3 mm, 75% average 12,75 mm, and 100% average 17 , 6 mm. Conclusion: Leaf kola infusion extract (Centella Asiatica L) on the growth of Staphylococcus aureus forming inhibit zone at concentrations 25%, 50%, 75%, and 100%.

Latar Belakang : Senyawa purin dari tuak yang berlebihan dapat meningkatkan kadar asam urat dalam darah. Meningkatnya produksi asam urat dalam tubuh, hal ini disebabkan karena sintesis atau pembentukan asam urat yang berlebihan (Hiperurisemia). Tujuan: Untuk Mengetahui gambaran kadar asam urat pada warga pengkonsumsi minuman tuak di Kecamatan Singgaran Pati Kota Bengkulu tahun 2019. Metode: Penelitian ini menggunakan desain penelitian deskriptif. Jumlah sampel dalam penelitian ini adalah 42 pasien dengan metode Accidental sampling. Hasil: Berdasarkan penelitian yang telah dilakukan pada responden sebanyak 28 0rang (67%) mengkonsumsi minuman tuak setiap hari, 14 orang (33%) mengkonsumsi minuman tuak kadang–kadang. Responden yang mengkonsumsi tuak setiap hari sebanyak 11 orang (26%) memiliki kadar asam urat normal, 17 orang (41%) memiliki kadar asam urat tidak normal (tinggi). Responden yang mengkonsumsi minuman tuak kadang-kadang sebanyak 14 orang, responden yang mengkonsumsi tuak kadang-kadang sebanyak 12 orang (28%) memiliki kadar asam urat normal, 2 orang (5%) memiliki kadar asam urat tidak normal (tinggi). Kesimpulan: Secara keseluruhan dari 42 orang responden yang diteliti 23 orang (55%) memiliki kadar asam urat normal dan 19 orang (45%) memiliki kadar asam urat tidak normal.

Uric acid as the nitrogen compounds produced from catabolism purine from both diet and endogenous nucleic acids (DNA deoxyribonucleic acid). One of the factors that can increase uric acid levels is the factor of excessive purine intake. The habit of consuming coffee can reduce levels of uric acid because the content of polyphenol compounds in coffee such as chlorogenic acid can inhibit the activity of the enzyme xanthine oxidase, thereby reducing levels of uric acid. The purpose of study was to determine differences in uric acid levels between subjects who consumed coffee and did not consume coffee in the Eastern Puskesmas area in 2018. This study included an analytical study with research design cross-sectional. The number of study subjects was 46 subjects aged 45-54 years. Spectrophotometer Rayto measured the level of uric acid in the blood, data on the history of gout and consumption habits were obtained using an observation sheet. Data analysis used test Mann-Whitney. There were differences in uric acid levels between subjects who consumed coffee and did not consume coffee in the East Rim Health Center area in 2018, the uric acid level of subjects who consumed coffee was lower than subjects who did not consume coffee (CI 95% 6.20, 7.80 ; p =0.001). Uric acid levels of subjects who consume coffee are lower than subjects who do not consume coffee, and coffee can be used as a non-pharmacological alternative treatment and prevention of Gout.