Renal failure is the loss of ability of kidneys to excrete waste products, concentrate urine, electrolytes and fluid balance leading to retention of creatinine, urea and other metabolic waste products that are normally excreted by the kidney. It is of two types, acute renal failure (ARF) or acute kidney injury (AKI) and chronic renal failure (CRF) or chronic kidney disease (CKD). Jacob et al., (2005) [5] reported that initial high UPC determination i.e. more than 1.0 in dogs with CRF was associated with greater risk of developing uremic crisis and death, compared to dogs with UPC less than 1.0 and thus concluded that UPC determination in dogs with CRF could be prognostic value. And also stated that determining urine specific gravity in a dehydrated patient quickly reveals its renal status. If the specific gravity is <1.015 in the dogs the animal had inadequate renal The investigation was carried out on 24 clinical cases suspected of renal failure in dogs on the basis of clinical signs admitted at Veterinary Clinical Complex (VCC),