Lower Vitamin D Metabolites Levels Were Associated With Increased Coronary Artery Diseases in Type 2 Diabetes Patients in India

Adela, Ramu; Borkar, Roshan M.; Bhandi, Murali Mohan; Vishwakarma, Gayatri; Reddy, P. Naveen Chander; Srinivas, R.; Banerjee, Sanjay K.

doi:10.1038/srep37593

Cited by 22 publications

(18 citation statements)

References 29 publications

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“…[ 9 ] 25-Hydroxyvitamin D3 (25OHD3) can be obtained from various sources: the exposure of the epidermis to the sunlight allows the body to synthesize 25OHD3, we can take additional supplements of fish oil which contains high levels of 25OHD3. [ 10 ] It has been found that lower serum 25OHD3 levels are epidemiologically related to higher occurrence of respiratory infections both in upper and lower respiratory tracts, and vitamin D deficiency is closely connected with badly aggravation of asthma. [ 11 ] It has been demonstrated that 25OHD3 supplementation helps more to elevate quality of life (QOL) effectively than to alleviate the pulmonary damages caused by severe asthma.…”

Section: Introductionmentioning

confidence: 99%

Serum levels of vitamin A and 25-hydroxyvitamin D3 (25OHD3) as reflectors of pulmonary function and quality of life (QOL) in children with stable asthma

Bai

Dai²

2018

Medicine

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Background:This study aims to explore the relationship between serum vitamin A and 25-hydroxyvitamin D3 (25OHD3) levels with pulmonary function and quality of life (QOL) in children with stable asthma.Methods:A total of 117 cases of children with stable asthma were assigned into the case group and 129 healthy children underwent physical examination during the same period into the control group. Electrochemiluminescence was employed to determine serum vitamin A and 25OHD3 levels. The children with stable asthma were further divided into the mild, moderate, and severe groups according to their degree of asthma. A pulmonary function meter was used to assess the pulmonary function indexes: percentage of forced expiratory volume in 1 sec/predictive value (FEV1%pred), forced vital capacity (FVC), forced expiratory volume in 1 sec/forced vital capacity (FEV1/FVC), peak expiratory flow (PEF), and maximal voluntary ventilation (MVV). The children's quality (QOL) of life with asthma was evaluated by their activities of daily living (ADLs) and Medical Research Council (MRC) scores. Pearson correlation analysis was applied to analyze the correlations of serum vitamin A and 25OHD3 levels with FEV1%pred, FVC, FEV1/FVC, PEF, MVV, ADL, and MRC.Results:Serum vitamin A and 25OHD3 levels were lower in children with stable asthma than those who were in the control group (P < .05). The severe group showed the lowest FEV1%pred, FVC, FEV1/FVC, PEF, MVV, and ADL scores, and the highest MRC score compared to the mild and moderate groups (all P < .05). Serum vitamin A and 25OHD3 levels were positively correlated with pulmonary function and ADL score in children with stable asthma, while serum vitamin A and 25OHD3 levels were negatively correlated with MRC score (all P < .05). In the case group, serum vitamin A and 25OHD3 levels were positively correlated with serum calcium and phosphorus levels (all P < .05).Conclusion:These findings indicate that increased serum vitamin A and 25OHD3 levels reflect good pulmonary function and good QOL in children with stable asthma.

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Section: Introductionmentioning

confidence: 99%

Serum levels of vitamin A and 25-hydroxyvitamin D3 (25OHD3) as reflectors of pulmonary function and quality of life (QOL) in children with stable asthma

Bai

Dai²

2018

Medicine

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“…Vitamin D has been gaining attention for non-classical roles such as regulation of inflammation, immunity, cell cycle and metabolism. Association between vitamin D deficiency and adverse cardiometabolic outcomes has been repeatedly shown in patients, but the therapeutic role of vitamin D supplementation remains controversial [3]. Clinical studies have yielded conflicting results regarding the potential benefits of vitamin D in subjects with cardiometabolic diseases [28,29].…”

Section: Discussionmentioning

confidence: 99%

“…We have earlier shown vitamin D deficiency is associated with increased prevalence of type 2 diabetes with and without coexisting coronary artery disease, both important risk factors for heart failure (3). Conditions such as chronic renal failure precipitate vitamin D deficiency as well as cardiac failure (4).…”

Section: Introductionmentioning

confidence: 99%

Paricalcitol reverses metabolic syndrome-associated heart failure through enhanced mitochondrial fusion

Nizami

Katare

Prabhakar

et al. 2020

Preprint

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Background & Purpose: We have earlier shown that vitamin D deficiency induces heart failure, in part, through insulin resistance. Whether activation of vitamin D receptor can attenuate heart failure, associated with metabolic syndrome, requires investigation. We aimed to assess cardioprotective potential of paricalcitol, a vitamin D receptor-activator, in high fat high fructose-fed rats. Experimental approach: Male Sprague Dawley rats were fed with control (Con) or high fat high fructose (HFHFrD) diet for 20 weeks. After 12 weeks, rats from HFHFrD group were divided into: HFHFrD, HFHFrD+P (paricalcitol i.p. 0.08 ug/kg/day) and HFHFrD+E (enalapril maleate i.p. 10 mg/kg/day). Intraperitoneal glucose tolerance test, blood pressure measurement and 2D echocardiography were performed. Cardiac fibrosis was assessed in Masson trichrome-stained paraffin-embedded heart sections. Mitochondrial DNA and proteins, and citrate synthase activity were measured in rat hearts. VDR was silenced in H9c2 cardiomyoblasts and immunoblotting was performed. Key Results: Paricalcitol improved glucose tolerance, serum lipid profile and blood pressure in high fat high fructose-fed rats. Paricalcitol reduced cardiac wall thickness, and increased ejection fraction in high fat high fructose-fed rats, with no effect on perivascular fibrosis. PGC1-α was uprgulated in HFHFrD+P group compared to HFHFrD group, without significant difference in mitochondrial content. Citrate synthase activity was significantly higher in HFHFrD+P group compared to HFHFrD group. Rat hearts of HFHFrD+P group had significantly higher expression of mitofusins. H9c2 cells with VDR knockdown showed significantly lower expression of Mfn2. Conclusion & Implications: Paricalcitol is cardioprotective in rats with metabolic syndrome, through improved mitochondrial dynamics, indicating repurposing potential.

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“…Vitamin D plays an essential function in the bone and mineral metabolism. Vitamin D deficiency is a frequent global health dilemma and is the reason for causing osteoporosis and osteomalacia, rickets, and other bone-related disorders [13]. In the most recent decade, researchers perceived that decreased serum 25-hydroxy vitamin D levels were related to metabolic diseases like type 1 diabetes, obesity, insulin resistance, cardiovascular diseases, and cancer [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Maternal and Neonatal Metabolic Outcomes of Vitamin D Supplementation in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

et al. 2018

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Introduction: Many scientists have revealed the association between vitamin D deficiency and gestational diabetes mellitus (GDM). The purpose of this review was to evaluate the impact of vitamin D supplementation on maternal and neonatal health measures in GDM. Methods: A comprehensive systematic literature search in the electronic databases including Cochrane Central Register of Controlled Trials, MEDLINE (PubMed), Scopus, Web of Sciences, EMBASE, Google Scholar, Clininaltrial.gov, and ProQuest as well as SID, Magiran, Irandoc, and Iranmedex for Persian literature review carried out up to January 2018. All RCTs and quasi-experimental studies that compared vitamin D supplementation with placebo or without supplementation on GDM women were included in this review. Results: Five randomized controlled trials involving 310 women were included in the meta-analysis. There were significant differences in fasting Plasma Glucose (FPG; mean difference [MD] –12.54, 95% CI –15.03 to –10.05; 3 trials, 223 participants); total cholesterol (TC; MD –24.77, 95% CI –32.57 to –16.98; 3 trials, 223 participants); low-density lipoprotein (LDL) cholesterol (MD –18.92, 95% CI –24.97 to –12.88; 3 trials, 223 participants); high-density lipoprotein (HDL) cholesterol (MD, 3.87, 95% CI 1.20–6.55; 3 trials, 223 participants); high sensitivity C-reactive protein (hs-CRP; MD –1.35, 95% CI –2.41 to –0.28; 2 trials, 126 participants); and Newborns’ hyperbilirubinemia (OR 0.33, 95% CI 0.13–0.80; 2 trials, 129 participants). Conclusions: Supplementation of GDM women with vitamin D may lead to an improvement in FPG, TC, LDL, HDL, hs-CRP serum levels as well as in newborns’ hyperbilirubinemia.

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Lower Vitamin D Metabolites Levels Were Associated With Increased Coronary Artery Diseases in Type 2 Diabetes Patients in India

Cited by 22 publications

References 29 publications

Serum levels of vitamin A and 25-hydroxyvitamin D3 (25OHD3) as reflectors of pulmonary function and quality of life (QOL) in children with stable asthma

Serum levels of vitamin A and 25-hydroxyvitamin D3 (25OHD3) as reflectors of pulmonary function and quality of life (QOL) in children with stable asthma

Paricalcitol reverses metabolic syndrome-associated heart failure through enhanced mitochondrial fusion

Maternal and Neonatal Metabolic Outcomes of Vitamin D Supplementation in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

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