Lowering of lipid composition in aorta of guinea pigs by Curcuma domestica

Ahmad-Raus, Raha; Abdul-Latif, Elda-Surhaida Es; Mohammad, Jamaludin J

doi:10.1186/1472-6882-1-6

Cited by 19 publications

(14 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Triglyceride content in aorta has been related to atherosclerosis in some studies [46] and has been demonstrated to be related to hypercholesterolemia. Similarly, in the present study, guinea pigs treated with RAPA had higher TG in plasma as well as in their aorta as compared to the control animals.…”

Section: Rapamycin and Liver And Aortamentioning

confidence: 98%

Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs

2006

View full text Add to dashboard Cite

Section: Rapamycin and Liver And Aortamentioning

confidence: 98%

Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs

2006

View full text Add to dashboard Cite

“…Ezekwe and Obidoa 37 have reported that flavoniods, tannins and saponins may play some roles in the hypolipidaemic effect of some plants. The mechanism of the hypocholesterolaemic action of these plant leaves may be due to inhibition of the absorption of dietary cholesterol in the intestine or its production by the liver 38 or stimulation of the biliary secretion of cholesterol and cholesterol excretion in faeces 39 .…”

Section: Discussionmentioning

confidence: 99%

Comparative Effects of the Leaves of <i>Gongronema latifolium</i> and <i>Vernonia amygdalina</i> Incorporated Diets on the Lipid Profiles of Rats

Ugwu¹,

Alumana²,

Ezeanyika³

2010

Biokemistri

View full text Add to dashboard Cite

The hypolipidaemic effects of the leaves of Gongronema latifolium (GL) and Vernonia amygdalina (VA) diet preparations on the lipid profile of rats were compared. The rats were fed for 28 days on diet specially formulated to contain 5%, 15% and 30% by weight of the leaves of each plant respectively while the control group was fed standard rat diet. The serum total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were determined on blood samples collected on the 28 th day. The results show that the VA diet induced a significantly lower serum total cholesterol level at the 15% and 30% concentrations relative to the GL diet preparation. The results also show that there was no significant difference between the effects of GL and VA diet preparations at the various levels of treatments. The comparison of the effects of the two diet preparations show that VA produced higher levels of HDL-C compared to GL which was significant at 5% and 15% concentrations respectively. It appears from our results that VA diet preparation may have better hyperlipidaemic effect than GL diet preparation. Therefore, VA may have better therapeutic promise in preventing lipid related pathologies compared to GL

show abstract

“…A 2 mm section of the aorta of each animal was soaked in 10% (v/v) formal saline solution for hematoxylin and eosin staining and another 2 mm section was placed in kriomatrix and kept at -20°C for frozen sections [21]. The remaining aorta was soaked in deionized water and homogenized for biochemical analyses.…”

Section: Histopathological Studiesmentioning

confidence: 99%

“…The tissue samples were ultrasectioned (5-6 lm thickness), stained with hematoxylin and eosin and examined under a light microscope for observation of structural abnormality. Ultra-thin sections of the frozen aorta (8 lm thickness) were stained with Schultz stain [21,22] and examined for cholesterol deposits.…”

Section: Histopathological Studiesmentioning

confidence: 99%

Hypolipidemic Effect of Celastrus paniculatus in Experimentally Induced Hypercholesterolemic Wistar Rats

2010

View full text Add to dashboard Cite

The objective of the present study was to evaluate hypolipidemic effect of methanolic extract of Celastrus paniculatus in experimentally induced hypercholesterolemic rats. Hypercholesterolemia was induced by feeding the animals with high fat diet. Oral administration of methanolic seed extract (50%) of Celastrus paniculatus at the optimized dose of 65 mg/kg body weight, substantially reduced the plasma total cholesterol, triglycerides and LDL cholesterol in comparison with induced hypercholesterolemic animal group and the results were comparable with the standard hypocholesterolemic drug and almost similar to the control group. Atherogenic index and liver weight of treated animals also showed significant decrease compared to the hypercholesterolemic animals. It substantially increased the HDL cholesterol level as compared to control group. A significant increase in the activities of lipoprotein lipase and plasma LCAT enhanced hepatic bile acid synthesis and thereby, increased degradation of cholesterol to neutral sterols. Furthermore, the activities of HMG-CoA reductase, glucose 6-phosphate dehydrogenase and malate dehydrogenase were significantly reduced. Histological studies showed less cholesterol deposits in the aorta of animals fed with seed extract of C. paniculatus compared to the induced hypercholesterolemic animals not given C. paniculatus supplement.

show abstract

Lowering of lipid composition in aorta of guinea pigs by Curcuma domestica

Abstract: Background: A short-term study was carried out using guinea pigs to determine the effects of Curcuma domestica on lipid composition in the serum and aorta.

Cited by 19 publications

References 8 publications

Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs

Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs

Comparative Effects of the Leaves of <i>Gongronema latifolium</i> and <i>Vernonia amygdalina</i> Incorporated Diets on the Lipid Profiles of Rats

Hypolipidemic Effect of Celastrus paniculatus in Experimentally Induced Hypercholesterolemic Wistar Rats

Contact Info

Product

Resources

About