Lowering the alcohol content of red wine does not alter its cardioprotective properties

Lamont, Kim; Blackhurst, Dee; Albertyn, Zulfah; Marais, David; Lecour, Sandrine

doi:10.7196/samj.5733

Cited by 9 publications

(9 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using both in vivo and in vitro models of myocardial I/R, studies from our laboratory demonstrate that the presence of melatonin in red wine may contributes to the protective effect of red wine against lethal I/R damage (Lamont et al, 2011 , 2015 ). This is supported by the findings that: (1) lowering the alcohol content of red wine does not alter its cardioprotective properties (Lamont et al, 2012 ); and (2) melatonin, given acutely and directly to the isolated heart at the concentration found in wine (75 ng/L) protects the isolated mouse and rat hearts against I/R injury by reducing myocardial infarct size and improving functional recovery (Lamont et al, 2011 ). (3) The cardioprotective effect of the consumption chronic and moderate red wine against I/R damage is partially abolished in the presence of prazosin, an inhibitor of melatonin receptor type 3 (M3) (Lamont et al, 2015 ).…”

Section: Role Of Dietary Melatonin In Cvdsmentioning

confidence: 82%

See 1 more Smart Citation

Cardiovascular Benefits of Dietary Melatonin: A Myth or a Reality?

2018

Self Cite

View full text Add to dashboard Cite

The role of the diet as well as the impact of the dietary habits on human health and disease is well established. Apart from its sleep regulatory effect, the indoleamine melatonin is a well-established antioxidant molecule with multiple health benefits. Convincing evidence supports the presence of melatonin in plants and foods with the intake of such foods affecting circulating melatonin levels in humans. While numerous actions of both endogenous melatonin and melatonin supplementation are well described, little is known about the influence of the dietary melatonin intake on human health. In the present review, evidence for the cardiovascular health benefits of melatonin supplementation and dietary melatonin is discussed. Current knowledge on the biological significance as well as the underlying physiological mechanism of action of the dietary melatonin is also summarized. Whether dietary melatonin constitutes an alternative preventive treatment for cardiovascular disease is addressed.

show abstract

Section: Role Of Dietary Melatonin In Cvdsmentioning

confidence: 82%

“…Very few studies have investigated the role of dietary melatonin in CVD. These are limited to the exploration of the cardioprotective effect of melatonin in red wine against myocardial I/R injury (Lamont et al, 2011 , 2012 , 2015 ; Nduhirabandi et al, 2016 ) and pulmonary hypertension (Maarman et al, 2015 ).…”

Section: Role Of Dietary Melatonin In Cvdsmentioning

confidence: 99%

Cardiovascular Benefits of Dietary Melatonin: A Myth or a Reality?

2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Most red wines contain 12% ethanol [ 46 ]. Further studies concerning lower concentrations of ethanol, and different types of composite resin are required.…”

Section: Discussionmentioning

confidence: 99%

Influence of Acid, Ethanol, and Anthocyanin Pigment on the Optical and Mechanical Properties of a Nanohybrid Dental Composite Resin

et al. 2018

View full text Add to dashboard Cite

This study investigated the influences of acidity, ethanol, and pigment on the optical properties, microhardness, and surface roughness (Ra) of a nanohybrid dental composite resin. A total of 108 disc-shaped specimens were fabricated using a nanohybrid dental composite and allocated into 36 different storage solutions according to the levels of pH (2.0, 3.0, 4.0, and 5.5), ethanol (0%, 20%, and 40%), and anthocyanin pigment (0%, 2.5%, and 12.5%). Measurements of the colorimetric parameter and the amount of color change (ΔE), translucency parameter (TP), microhardness, and surface roughness (Ra) were performed at 24 h (baseline), 1-, 2-, 3-, and 4-weeks. Repeated measures of analysis of variance (ANOVA) with a Tukey honestly significant difference test and Pearson correlation analysis were carried out (α = 0.05). Pigment of 12.5% or 40% ethanol significantly increased the ΔE (P < 0.001, P = 0.048, respectively). Pigment of 2.5% or 12.5% significantly decreased the TP (P = 0.001, P < 0.001, respectively). Microhardness of composite resin stored in pH 2.0, 3.0, 4.0 solution was lower than that for pH 5.5 (P < 0.001). Pigment, ethanol, and pH did not influence the Ra. TP change and ΔE, and Ra and ΔE had a significant positive correlation (P < 0.05). In conclusion, pigment and ethanol levels influenced the optical properties and acidity affected the microhardness of composite resin.

show abstract

“…Multiple epidemiological and experimental studies suggest that moderate and chronic consumption of red wine confers health benefits, an effect that can be attributed to both alcohol and other compounds in wine [ 4 , 5 ]. Indeed, lowering the alcohol levels in wine does not seem to affect the cardioprotective effect of regular and moderate consumption of wine against ischemia–reperfusion injury but it presents the beneficial effect of potentially limiting the adverse effects of alcohol [ 4 ]. In humans, moderate consumption of wine may decrease the risk of chronic obstructive pulmonary disease [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Chronic and moderate consumption of reduced-alcohol wine confers cardiac benefits in a rat model of pulmonary arterial hypertension

et al. 2021

Self Cite

View full text Add to dashboard Cite

Objectives In pulmonary arterial hypertension (PAH), right ventricular (RV) dysfunction develops via mechanisms involving oxidative stress. Moderate and chronic red wine (RW) consumption reduces oxidative stress and confers cardioprotection but its effect on PAH is unknown. We evaluated whether moderate and chronic consumption of reduced-alcohol RW (RARW) confers cardioprotection in a monocrotaline (MCT)-induced PAH rat model. Results Rats were randomly grouped: control; MCT; RARW; MCT + RARW. Wine was diluted to mimic moderate intake for humans, and consumed from 7 days before, until 28 days after MCT-injection. Echocardiography measured pulmonary artery acceleration time (PAAT) and RV thickness. Conjugated dienes (CD), and thiobarbituric acid reactive substances (TBARS) concentrations were assessed. MCT induced RV thickness and decreased PAAT compared to controls [1.22 ± 0.09 mm vs 0.46 ± 0.02 mm and 14 ± 1 vs 23 ± 2 m/s, respectively (p < 0.001)]. Chronic RARW consumption limited MCT-induced RV hypertrophy and increased PAAT. CD and TBARS increased in MCT-treated animals compared to controls (672 ± 43 nmol/L vs 453 ± 35 nmol/L; p < 0.01 and 13 ± 2 µmol/L vs 4 ± 0.3 µmol/L; p < 0.01). RARW reduced MCT-induced CD (472 ± 27 nmol/L vs 672 ± 43 nmol/L; p < 0.01). Conclusion Chronic and moderate intake of RARW ameliorates MCT-induced PAH in rats, which may be partly attributable to reduction of lipid peroxidation.

show abstract

Lowering the alcohol content of red wine does not alter its cardioprotective properties

Cited by 9 publications

References 14 publications

Cardiovascular Benefits of Dietary Melatonin: A Myth or a Reality?

Cardiovascular Benefits of Dietary Melatonin: A Myth or a Reality?

Influence of Acid, Ethanol, and Anthocyanin Pigment on the Optical and Mechanical Properties of a Nanohybrid Dental Composite Resin

Chronic and moderate consumption of reduced-alcohol wine confers cardiac benefits in a rat model of pulmonary arterial hypertension

Contact Info

Product

Resources

About