We study lepton flavor violating meson decays induced by box diagrams involving a vector leptoquark (LQ) and scalar fields in Pati-Salam (PS) unification with vector-like families. The vector LQ corresponds to the massive gauge boson associated with the PS gauge symmetry breaking and the scalar fields are the physical degrees of freedom of the PS breaking field. The LQ generally causes the rapid flavor violating decays, such as K L → µe, at the tree-level unless its mass scale is higher than PeV scale. The vector-like families are introduced to suppress the tree-level contributions mediated by the LQ and explain the realistic fermion mass matrices. In this paper, we point out that there are inevitable one-loop contributions to those meson decays from the box diagrams mediated by both one LQ and one scalar field, even if the tree-level contributions are suppressed. We consider a concrete model for demonstration, and find that the vector-like fermion masses have an upper bound for a given LQ mass when the one-loop induced meson decays are consistent with the experimental limits. The vector-like fermion mass should be lighter than 3 TeV for 20 TeV LQ, if a combination of the couplings does not suppress K L → µe decay. Our findings would illustrate importance of the box diagrams involving both LQ and physical modes of symmetry breaking scalars in generic models.