Loxoprofen sodium induces the production of complement C5a in human serum

Kumagai, Tomoaki; Yamaguchi, Naohito; Hirai, Hiroyuki; Kojima, Shigeyuki; Kodani, Yoshiko; Hashiguchi, Akihiko; Haida, Michiko; Nakamura, Masataka

doi:10.1016/j.intimp.2016.01.025

Search citation statements

Order By: Relevance

Paper Sections

Select...

Discussion1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2018

2023

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

(1 citation statement)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 24-hour BAT suggests basophil degranulation via classical complement pathway activation. 11 In other words, ropivacaine may cause anaphylaxis without antigen presentation by antigen-presenting cells. Some drugs bind directly to immune receptors, inducing non-IgE-mediated responses within hours of drug administration.…”

Section: Discussionmentioning

confidence: 99%

Delayed Nonimmune Anaphylaxis Caused by Ropivacaine for Preoperative Nerve Blocks: A Case Report

Ishii,

Miyoshi,

Kubo

et al. 2023

A&A Practice

View full text Add to dashboard Cite

Ropivacaine is an amide local anesthetic with rare reports of anaphylaxis. To our knowledge, this is the first report of delayed nonimmune anaphylaxis induced by ropivacaine. A 70-year-old man underwent general anesthesia with a nerve block for a total knee arthroplasty. The patient developed symptoms of anaphylaxis 3.5 hours after receiving ropivacaine for femoral and tibial nerve blocks. A basophil activation test (BAT) revealed ropivacaine as the causative agent. Notably, anaphylaxis can be caused by medications even hours after their administration, and all administered drugs should be suspected of potentially causing anaphylaxis.

show abstract

Section: Discussionmentioning

confidence: 99%