Lp(a) in hypertensive patients

Catalano, M.; Perilli, Edoardo; Carzaniga, Gianni; Colombo, Fabrizio; Carotta, Maria; Andreoni, Simona

doi:10.1038/sj.jhh.1000540

Cited by 24 publications

(18 citation statements)

References 7 publications

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“…32 In addition, several studies have found a correlation between the prevalence of hypertension in blacks and both higher levels of lipoprotein(a) and greater thickness of the left ventricular septal and posterior walls. 33,34 It has also been shown that African Americans respond less favorably to certain antihypertensive drug therapies, particularly ␤-blockers and ACE inhibitors. 35 Sociocultural, economic, and environmental determinants may also influence the potency of certain risk factors such as hypertension in blacks and Hispanics.…”

Section: Discussionmentioning

confidence: 99%

Race-Ethnic Disparities in the Impact of Stroke Risk Factors

Sacco

Boden‐Albala

Abel

et al. 2001

Stroke

345

259

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Background and Purpose-Stroke risk factors have been determined in large part through epidemiological studies in white cohorts; as a result, race-ethnic disparities in stroke incidence and mortality rates remained unexplained. The aim in the present study was to compare the prevalence, OR, and etiological fraction (EF) of stroke risk factors among white, blacks, and Caribbean Hispanics living in the same urban community of northern Manhattan. Methods-In this population-based incident case-control study, cases (nϭ688) of first ischemic stroke were prospectively matched 1:2 by age, sex, and race-ethnicity with community controls (nϭ1156). Risk factors were determined through in-person assessment. Conditional logistic regression was used to calculate adjusted ORs in each race-ethnic group. Prevalence and multivariate EFs were determined in each race-ethnic group.

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Section: Discussionmentioning

confidence: 99%

Race-Ethnic Disparities in the Impact of Stroke Risk Factors

Sacco

Boden‐Albala

Abel

et al. 2001

Stroke

345

259

View full text Add to dashboard Cite

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“…In the present study, it was found that the hypertensive patients had higher plasma concentrations of Lp (a) than in the controls. In a similar study, Catalano et al 8 reported significantly elevated levels of plasma Lp(a) in 123 Caucasian essential arterial hypertensive patients (47 men and 76 women). The pathogenicity and atherogenic role of Lp (a) is greatly influenced by the concentration of other serum lipids and lipoproteins.…”

Section: Discussionmentioning

confidence: 79%

Serum Lipoprotein (a) as an independent marker of cardiovascular risk in patients with Essential Hypertension

Vyas

Sirajwala

2013

Int J of Biomed & Adv Res

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Aim: Aims of study was to find out the level of serum lipoprotein (a) in healthy and hypertensive subjects and role of serum lipoprotein (a) as an independent marker of cardiovascular risk in patients with essential hypertension.

Material and Method: 100 patients with essential hypertension and 50 apparently healthy subjects were included in study. Sera were collected from them and measure serum Lipoprotein(a) with Latex Turbidimetric method on automated chemistry analyzer. Unpaired T-test was used to assess the significant difference in the means of the studied variables in the different groups.

Results: The mean level of Serum Lipoprotein(a) is higher in patients with essential hypertension comparing with the control group (21.6 ± 11.9 and 30.3 ± 13.6,p <0.001).

Conclusion: The findings clearly project that plasma concentration of Lp(a) albeit within normal range could be an independent risk factor for atherosclerosis and could contribute towards increasing the risk for cardiovascular diseases in persons with essential hypertension.

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“…Our present study demonstrated no significant differences in the conventional lipid profile, but that may be because lipid lowering drugs are commonly prescribed medication for hypertensive patients in Thailand. Some patients may have had clinically silent vascular disease resulting from increased Lp(a), hs-CRP levels and oxidative stress, rather than by hypertension [17]. Thus, the increased concentrations of Lp(a), hs-CRP and decreased eGFR in the hypertensive patients could constitute a first pathological sign, in the absence of organ damages.…”

Section: Discussionmentioning

confidence: 99%

Association of Elevated Serum Lipoprotein(a), Inflammation, Oxidative Stress and Chronic Kidney Disease with Hypertension in Non-diabetes Hypertensive Patients

2016

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Hypertension is the most common cardiovascular risk factor. Lipoprotein(a) [Lp(a)], inflammation, oxidative stress and chronic kidney disease (CKD) exacerbate the response to tissue injury and acts as markers of the vascular disease, especially in glomerulosclerosis. We compared the clinical characteristics of 138 non-diabetes hypertensive women (ndHT) patients with 417 non-diabetes normotensive subjects and tested the association of hypertension with Lp(a), inflammation, CKD and oxidative stress by using multiple logistic regression. BP, BMI, waist circumference, creatinine, Lp(a), inflammation and malondialdehyde levels were significantly higher and CKD state in the ndHT patients (p \ 0.05). Multiple logistic regression showed hypertension associated with increased Lp(a), inflammation, ORs and 95 % CIs were 2.52 (1.33, 4.80), 2.75 (1.44, 5.27) after adjusting for their covariates. Elevated serum Lp(a) and inflammation levels concomitants with increased oxidative stress and CKD were the major risk factors associated with hypertension and implications for the increased risk of HT and vascular disease.

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Lp(a) in hypertensive patients

Cited by 24 publications

References 7 publications

Race-Ethnic Disparities in the Impact of Stroke Risk Factors

Race-Ethnic Disparities in the Impact of Stroke Risk Factors

Serum Lipoprotein (a) as an independent marker of cardiovascular risk in patients with Essential Hypertension

Association of Elevated Serum Lipoprotein(a), Inflammation, Oxidative Stress and Chronic Kidney Disease with Hypertension in Non-diabetes Hypertensive Patients

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