LPO and ROS Production in Rat Brain Exposed to Microwaves: Computational Elucidation of Melatonin in Repair System

Kesari, Kavindra Kumar; Jamal, Qazi Mohammad Sajid; Sharma, Archana; Chauhan, Prem M. S.; Dhasmana, Anupam; Siddiqui, Mohammad Haris; Sisodia, Rashmi; Verma, H. N.

doi:10.1007/978-3-319-46248-6_2

Cited by 5 publications

(5 citation statements)

References 57 publications

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“…In addition, medical interventions through the use of antioxidants are also beneficial for protection against EMR, though specific drugs are lacking. Possible medications include melatonin (28) , carnitine, caffeic acid phenethyl ester (CAPE) (59) , vitamin C (60) and different kinds of Chinese medicines (61) .…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, in the study reported by Xing et al (26) , it has been shown that 1800MHz microwave activates caspase-3 signaling pathway that leads to cell apoptosis through enhancing ROS production and DNA damage, which is consistent with another study (27) in that microwave induced non-small cell lung cancer (NSCLC) cells apoptosis by increasing the production of ROS in-vivo. In addition, Kavindra et al (28) also revealed that exposure of 2.45 GHz microwave frequency adversely affects the whole brain and cause oxidative damage by increased levels of lipid peroxide (LPO) and ROS. (26) 1800MHz 1209 mW/m 2 Mouse NIH/3T3 and human U-87 MG cells ROS increased 2018 Zhao et al (27) 433 MHz NSCLC cells ROS increased 2017 Kavindra et al (28) 2.45 GHz 0.2 mW/cm 2 brain of rats LPO and ROS increased…”

Section: Int J Radiat Res Vol 19 No 3 July 2021mentioning

confidence: 99%

“…In addition, Kavindra et al (28) also revealed that exposure of 2.45 GHz microwave frequency adversely affects the whole brain and cause oxidative damage by increased levels of lipid peroxide (LPO) and ROS. (26) 1800MHz 1209 mW/m 2 Mouse NIH/3T3 and human U-87 MG cells ROS increased 2018 Zhao et al (27) 433 MHz NSCLC cells ROS increased 2017 Kavindra et al (28) 2.45 GHz 0.2 mW/cm 2 brain of rats LPO and ROS increased…”

Section: Int J Radiat Res Vol 19 No 3 July 2021mentioning

confidence: 99%

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The non-thermal biological effects and mechanisms of microwave exposure

Zhao¹,

Dong²,

Wang³

2021

Int J Radiat Res

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The purpose of this article was to present a brief review of pertinent information regarding the effects of microwave radiation on biological systems. Researchers have been intrigued by the interaction of electromagnetic fields (EMFs) and various life processes since the 18th century. Microwaves refer to the oscillation of an EMF with a wavelength of 1 mm to 1 m, which penetrates matter to varying degrees. With the widespread and ever-increasing use of microwaves, such as cellular telephones and other wireless technologies, great attention and research has been paid to the potential adverse biological effects. It is well recognized that microwaves affect the biological functions of living organisms at both the cellular and molecular levels, and can lead to the appearance of toxicity, genotoxicity and transformation. However, until now no satisfactory mechanism has been proposed to explain the biological effects of these fields. Therefore, increasing attention should be focused on the biological effects of microwaves in the future, especially since microwaves have extensive applications in various fields.

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Section: Discussionmentioning

confidence: 99%

Section: Int J Radiat Res Vol 19 No 3 July 2021mentioning

confidence: 99%

Section: Int J Radiat Res Vol 19 No 3 July 2021mentioning

confidence: 99%

See 1 more Smart Citation

The non-thermal biological effects and mechanisms of microwave exposure

Zhao¹,

Dong²,

Wang³

2021

Int J Radiat Res

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“…In the brain tissue of rats, melatonin was able to prevent oxidative damage but failed to prevent the decrease in CAT levels caused by microwave radiation from phones [ 86 ]. Also, both 2.45 GHz RF-EMF-induced lipid peroxidation and ROS levels were decreased in the brain of rats after melatonin administration [ 87 ]. Melatonin was able to prevent rat hippocampal cell loss caused by exposure to RF-EMF at 900MHz prenatally [ 88 ].…”

Section: Melatonin As a Radio-protective Agent Against Emf: Implicati...mentioning

confidence: 99%

Melatonin: a Potential Shield against Electromagnetic Waves

Jammoul

Lawand

2022

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: Melatonin, a vital hormone synthesized by the pineal gland, has been implicated in various physiological functions and in circadian rhythm regulation. Its role in the protection against the non-ionizing electromagnetic field (EMF), known to disrupt the body’s oxidative/anti-oxidative balance, has been called into question due to inconsistent results observed across studies. This review provides the current state of knowledge on the interwoven relationship between melatonin, EMF, and oxidative stress. Based on synthesized evidence, we present a model that best describes the mechanisms underlying the protective effects of melatonin against RF/ELF-EMF induced oxidative stress. We show that the free radical scavenger activity of melatonin is enabled through reduction of the radical pair singlet-triplet conversion rate and the concentration of the triplet products. Moreover, this review aims to highlight the potential therapeutic benefits of melatonin against the detrimental effects of EMF, in general, and electromagnetic hypersensitivity (EHS), in particular.

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“…Microwaves sensitively affect some biological organs in addition to the CNS, reproductive, cardiovascular, and hematopoietic systems. Furthermore, EMR exposure increases reactive oxygen species (ROS) levels inside of tissues [ 40 ], leading to macromolecular changes, including DNA/RNA and proteins. This induced oxidative stress increases malondialdehyde, leading to membrane lipid injury, and a reduced glutathione concentration, which plays a key defensive role against various diseases [ 41 ].…”

Section: Introductionmentioning

confidence: 99%

Microwave Radiation and the Brain: Mechanisms, Current Status, and Future Prospects

Mumtaz

Rana

Choi

et al. 2022

IJMS

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Modern humanity wades daily through various radiations, resulting in frequent exposure and causing potentially important biological effects. Among them, the brain is the organ most sensitive to electromagnetic radiation (EMR) exposure. Despite numerous correlated studies, critical unknowns surround the different parameters used, including operational frequency, power density (i.e., energy dose), and irradiation time that could permit reproducibility and comparability between analyses. Furthermore, the interactions of EMR with biological systems and its precise mechanisms remain poorly characterized. In this review, recent approaches examining the effects of microwave radiations on the brain, specifically learning and memory capabilities, as well as the mechanisms of brain dysfunction with exposure as reported in the literature, are analyzed and interpreted to provide prospective views for future research directed at this important and novel medical technology for developing preventive and therapeutic strategies on brain degeneration caused by microwave radiation. Additionally, the interactions of microwaves with biological systems and possible mechanisms are presented in this review. Treatment with natural products and safe techniques to reduce harm to organs have become essential components of daily life, and some promising techniques to treat cancers and their radioprotective effects are summarized as well. This review can serve as a platform for researchers to understand the mechanism and interactions of microwave radiation with biological systems, the present scenario, and prospects for future studies on the effect of microwaves on the brain.

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LPO and ROS Production in Rat Brain Exposed to Microwaves: Computational Elucidation of Melatonin in Repair System

Cited by 5 publications

References 57 publications

The non-thermal biological effects and mechanisms of microwave exposure

The non-thermal biological effects and mechanisms of microwave exposure

Melatonin: a Potential Shield against Electromagnetic Waves

Microwave Radiation and the Brain: Mechanisms, Current Status, and Future Prospects

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