Proceedings of the 2014 Biomedical Sciences and Engineering Conference 2014
DOI: 10.1109/bsec.2014.6867742
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LRP-1 modulates glutamate-induced phase shifting in the mouse SCN circadian clock

Abstract: In the mammalian circadian clock located in the suprachiasmatic nucleus (SCN) glutamate mimics light-induced phase shifts through activating NMDA receptors (NMDAR). These phase shifts require concurrent activation of TrkB receptors by brain-derived neurotrophic factor (BDNF). tPA contributes to phase shifting by influencing mBDNF generation. tPA also binds to receptors, including LRP-1, and may modulate phase shifting through non-proteolytic mechanisms related to such receptor binding. Here we investigate the … Show more

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