LSG vs MGB-OAGB—3 Year Follow-up Data: a Randomised Control Trial

Shivakumar, S.; Tantia, Om; Goyal, Ghanshyam; Chaudhuri, Tamonas; Khanna, Shashi; Ahuja, Anmol; Poddar, Anshuman; Majumdar, Kajari

doi:10.1007/s11695-018-3255-3

Cited by 53 publications

(28 citation statements)

References 43 publications

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“…Following systematic searches in MEDLINE, EMBASE and trial registries, 2291 abstracts were identified, and following exclusions, 25 articles regarding 20 RCTs (1803 patients) were included [ 35 – 59 ] (Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…At 2 years, 4 RCTs compared RYGB with SG, 2 RCTs compared RYGB v OAGB and 2 RCTs compared SG with OAGB [ 39 , 41 , 43 , 46 , 47 , 53 , 57 , 59 ] (Table 2 ). In standard meta-analysis, no approach was favoured over another for EWL at 2-year follow-up.…”

Section: Resultsmentioning

confidence: 99%

“…At 3–5 years, 7 RCTs compared RYGB with SG, 1 RCT compared RYGB v OAGB and 2 RCTS compared SG with OAGB [ 39 , 41 , 46 , 48 , 55 – 59 ] (Table 2 ). In standard meta-analysis, RYGB had greater EWL than SG at between 3 and 5 years postoperatively.…”

Section: Resultsmentioning

confidence: 99%

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Network Meta-Analysis of Metabolic Surgery Procedures for the Treatment of Obesity and Diabetes

et al. 2021

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Background Metabolic surgery is part of a well-established treatment intensification strategy for obesity and its related comorbidities including type 2 diabetes (T2DM). Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG) and one-anastomosis gastric bypass (OAGB) are the most commonly performed metabolic surgeries worldwide, but comparative efficacy is uncertain. This study employed network meta-analysis to compare weight loss, T2DM remission and perioperative complications in adults between RYGB, SG and OAGB. Methods MEDLINE, EMBASE, trial registries were searched for randomised trials comparing RYGB, SG and OAGB. Study outcomes were excess weight loss (at 1, 2 and 3–5 years), trial-defined T2DM remission at any time point and perioperative complications. Results Twenty randomised controlled trials were included involving 1803 patients investigating the three metabolic surgical interventions. RYGB was the index for comparison. The excess weight loss (EWL) demonstrated minor differences at 1 and 2 years, but no differences between interventions at 3–5 years. T2DM remission was more likely to occur with either RYGB or OAGB when compared to SG. Perioperative complications were higher with RYGB when compared to either SG or OAGB. Two-way analysis of EWL and T2DM remission against the risk of perioperative complications demonstrated OAGB was the most positive on this assessment at all time points. Conclusion OAGB offers comparable metabolic control through weight loss and T2DM remission to RYGB and SG whilst minimising perioperative complications. Registration number: CRD42020199779 (https:// www.crd.york.ac.uk/PROSPERO ) Graphical abstract

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Network Meta-Analysis of Metabolic Surgery Procedures for the Treatment of Obesity and Diabetes

et al. 2021

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“…While the efficacy and safety of OAGB have been validated [ 3 , 4 , 5 ] and its ability to control dyslipidemia has now been demonstrated [ 9 , 14 , 24 ], this approach is included in the ongoing debate on which procedure is the most effective in such patients. A moderate amount of studies focused on remission of T2DM, comparing OAGB with other surgical procedures [ 8 , 9 , 11 , 25 , 26 , 27 ]. Thus, this study attempts to compare LSG and OAGB in term of improvement of lipid profile in patients with severe obesity.…”

Section: Discussionmentioning

confidence: 99%

Improvement of Lipid Profile after One-Anastomosis Gastric Bypass Compared to Sleeve Gastrectomy

et al. 2021

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Fewer studies compared the improvement of plasma lipid levels after different types of surgery, in particular compared to one-anastomosis gastric bypass (OAGB). The aim of our study was to investigate how laparoscopic sleeve gastrectomy (LSG) and OAGB impact on weight loss and lipid profile 18 months after surgery, in patients with severe obesity. Forty-six patients treated with OAGB were matched to eighty-eight patients submitted to LSG. Weight loss after OAGB (33.2%) was more evident than after LSG (29.6%) (p = 0.024). The difference in the prevalence of dyslipidemia showed a statistically significant reduction only after OAGB (61% versus 22%, p < 0.001). After adjustment for delta body mass index (BMI), age and sex, we demonstrated a statistically significant decrease of the differences between the changes before and after (delta Δ) the two surgery procedures: Δ total cholesterol values (p < 0.001), Δ low density lipoprotein-cholesterol values (p < 0.001) and Δ triglycerides values (p = 0.007). Patients with severe obesity undergoing to OAGB presented a better improvement of lipid plasma values than LSG patients. The reduction of lipid plasma levels was independent of the significant decrease of BMI after surgery, of age and of sex.

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“…Bariatric surgery has become one of the most efficient methods for treating morbid obesity, not only because it dramatically reduces weight loss, but also by resolving associated comorbidity as well (4). Post-operative weight loss is also stimulated by the decreased production of hormones related to obesity such as ghrelin, which is vastly produced by the cells of the gastric fundus, the majority of which is removed during sleeve gastrectomy (SG).…”

Section: Introductionmentioning

confidence: 99%

Metabolic and Hormonal Changes after Sleeve Gastrectomy and Mini Gastric Bypass in a Rat Model of Induced Type 2 Diabetes Mellitus and Obesity

Stoica¹,

Dobrescu²,

Isaic³

et al. 2019

chr

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Introduction: Obesity is one of the leading causes of social, economic and health problems throughout the world and in the past years bariatric surgery has emerged as a method to alleviate this problem. We have conducted an experimental study aimed at comparing the metabolic and hormonal changes after sleeve gastrectomy and mini gastric bypass , two bariatric procedures showing promising results. Material and Methods: We have designed a study using a rat model with induced type 2 diabetes mellitus and obesity divided into three groups: a sleeve gastrectomy group, a mini gastric bypass group and a sham operated group, all of which had their glycemia, lipid profile, ghrelin and insulin levels measured before and after the procedures. Results: The results showed a significant decrease (p<0.05) in fasting glucose levels, lipid profile and ghrelin levels in the mini gastric bypass compared to the sleeve gastrectomy group. Conclusions: This study has demonstrated that both SG and MGB are effective treatments for morbid obesity and T2DM and both procedures can significantly resolve obesity-related metabolic changes.

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LSG vs MGB-OAGB—3 Year Follow-up Data: a Randomised Control Trial

Cited by 53 publications

References 43 publications

Network Meta-Analysis of Metabolic Surgery Procedures for the Treatment of Obesity and Diabetes

Network Meta-Analysis of Metabolic Surgery Procedures for the Treatment of Obesity and Diabetes

Improvement of Lipid Profile after One-Anastomosis Gastric Bypass Compared to Sleeve Gastrectomy

Metabolic and Hormonal Changes after Sleeve Gastrectomy and Mini Gastric Bypass in a Rat Model of Induced Type 2 Diabetes Mellitus and Obesity

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