<b>Cytotoxic and genotoxic effects of <i>Solanum lycocarpum </i> St.-Hil (Solanaceae) on the cell cycle of <i>Lactuca sativa</i> and <i>Allium cepa

Abstract

Solanum lycocarpum St.-Hil popularly known as 'fruta-de-lobo' or 'lobeira' is native to the Brazilian Cerrado, and used in folk medicine due to its phytotherapic properties. The action of S. lycocarpum on the cell cycle and chromosomes in order to demonstrate whether there are aneugenic and/or clastogenic effects is unknown. Thus, this study aimed at investigating the cytotoxic and genotoxic potential of methanol and hexane extracts of S. lycocarpum on growth and cell cycle of Lactuca sativa and Allium cepa. Roots from both species were exposed for 72 hours to methanol and hexane extracts with 50, 100, and 200 μg mL-1 of S. lycocarpum. Slides were prepared by the squash technique and then analyzed to determine the mitotic index and the total of chromosomal and nuclear abnormalities. The frequencies of chromosomal and nuclear abnormalities were high and significant with a dose-dependent effect, indicating that S. lycocarpum has a cytotoxic and genotoxic action depending on the dose used on meristem cells of A. cepa and L. sativa.

Sulfur supplementation mitigates drought-induced deleterious effects on soybean plants

“…Por outro lado, os eventos clastogênicos causam a quebra cromossômica, formando pontes e aderência cromossômicas. A quebra de segmentos de cromossomos pode ocasionar a fusão inter ou intracromatínica, gerando formas irreversíveis de aderência ou levando a morte celular (CHIAVEGATTO et. al, 2017).…”

Phytochemical screening and evaluation of phytotoxic activity of Solanum lycocarpum (Solanaceae) ripe fruit

“…This species is widely used in folk medicine as a sedative, in the treatment of epilepsy, diabetes, obesity, reduction of cholesterol levels, and in the preparation of influenza syrups (Dall'Agno & Von Poser, 2000). Previous studies have shown that fruits of S. lycocarpum exhibit allelopathic, anti-inflammatory, antimicrobial, antioxidant, antitumoral, cytotoxic, genotoxic and larvicidal activities (Morais, Silva, Oliveira, Ferreira, & Lima, 2013;Pereira, Silva, Ribeiro Neto, Alves, & Lima, 2014;Morais et al, 2015;Silva, Ribeiro Neto, Alves, & Lima, 2015;Chiavegatto, Chaves, Silva, Lima, & Techio, 2017;Morais et al, 2017;Bahia et al, 2018;Morais et al, 2018;Silva et al, 2018;Silva, Fonseca, Coimbra, Duarte-Almeida, & Lima, 2019).…”

Efeitos da extração hidroetanolica e sequencial sobre o potencial tóxico dos extratos de diferentes partes da Parkia platycephala do Cerrado tocantinense

“…Vernonanthura polyanthes (assa-peixe) e observaram efeitos tóxicos da espécie em concentrações superiores a 20 mg/ml Chiavegatto et al (2017). relataram que os extratos metanolicos do fruto da Solanum lycocarpum (lobeira) têm um efeito inibitório sobre o crescimento das raízes tanto da A. cepa quanto da Lactuca sativa.…”