&lt;b&gt;&lt;i&gt;Exserohilum rostratum&lt;/i&gt;&lt;/b&gt; Keratitis in a Patient with Human Immunodeficiency Virus

Chaidaroon, Winai; Phaocharoen, Nutt; Srisomboon, Titipol; Vanittanakom, Nongnuch

doi:10.1159/000499688

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…2014, an open access article), (c) Bipolaris hawaiiensis (adapted from Chaidaroon et al . 2019, an open access article) and (d) Exserohilum mcginnisii (adapted from Qiu and Yao 2013, an open access article).…”

Section: Major Dh Causing Mycotic Keratitismentioning

confidence: 99%

Recent advances on mycotic keratitis caused by dematiaceous hyphomycetes

Rai

Ingle

et al. 2021

J Appl Microbiol

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Dematiaceous hyphomycetes (DH) are darkly pigmented fungi ubiquitously found all over the world as plant pathogens and saprophytes, and many of the members of this group have emerged as opportunistic pathogens. These fungi are responsible for a wide variety of infections including mycotic keratitis, which is considered as one of the major causes of corneal blindness, particularly in tropical and subtropical countries with an annual global burden of about 1 000 000 patients. The infection is more common in workers working in an outdoor environment. Moreover, trauma is found to be the most important predisposing cause of mycotic keratitis. Considerable delay in diagnosis and scarcity of effective pharmacological drugs are the major factors responsible for increased morbidity and visual impairment. Considering the crucial role of DH in mycotic keratitis, in the present review, we have focused on major DH with special emphasis on their pathogenicity, diagnosis and treatment strategies.

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Section: Major Dh Causing Mycotic Keratitismentioning

confidence: 99%

Recent advances on mycotic keratitis caused by dematiaceous hyphomycetes

Rai

Ingle

et al. 2021

J Appl Microbiol

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“…Among these species, E. rostratum has been described as a phytopathogen; however, an outbreak of fungal meningitis associated with contaminated methylprednisolone injections was reported by the Center of Diseases Control (CDC) in the United States in 2012 [ 9 ], culminating in the death of 8% of patients after 12 months of the diagnostic [ 10 ]. Cases of sinusitis [ 11 ] and keratitis [ 12 ] were also reported. Lately, this species has been successfully used as a model of rabbit meningoencephalitis [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Monocerin, a Fungal Secondary Metabolite, on Endothelial Cells

Gomes

Conrado

Oliveira

et al. 2023

Toxins

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This study reports the isolation and identification of the endophytic fungus Exserohilum rostratum through molecular and morphological analysis using optical and transmission electron microscopy (TEM), as well as the procurement of its secondary metabolite monocerin, an isocoumarin derivative. Considering the previously observed biological activities of monocerin, this study was performed on human umbilical vein endothelial cells (HUVECs) that are widely used as an in vitro model for several different purposes. Important parameters, such as cell viability, senescence-associated β-galactosidase, cellular proliferation by using 5(6)-carboxyfluorescein diacetate N-succinimidyl ester (CFSE), apoptosis analysis with annexin, cellular morphology through scanning electron microscopy (SEM), and laser confocal analysis were evaluated after exposing the cells to monocerin. After 24 h of exposure to monocerin at 1.25 mM, there was more than 80% of cell viability and a low percentage of cells in the early and late apoptosis and necrosis. Monocerin increased cell proliferation and did not induce cell senescence. Morphological analysis showed cellular integrity. The study demonstrates aspects of the mechanism of action of monocerin on endothelial cell proliferation, suggesting the possibility of its pharmaceutical application, such as in regenerative medicine.

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