&lt;b&gt;&lt;i&gt;Lactococcus lactis&lt;/i&gt;&lt;/b&gt; NZ9000 Prevents Asthmatic Airway Inflammation and Remodelling in Rats through the Improvement of Intestinal Barrier Function and Systemic TGF-β Production

Cervantes‐García, Daniel; Jiménez, Mariela; Rivas‐Santiago, César; Gallegos-Alcalá, Pamela; Hernández-Mercado, Alicia; Santoyo-Payán, Leslie S; Loera‐Arias, María de Jesús; Saucedo‐Cárdenas, Odila; Oca‐Luna, Roberto Montes de; Salinas, Eva

doi:10.1159/000511146

Cited by 22 publications

(19 citation statements)

References 64 publications

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“…A beneficial effect of the administration of probiotics was suggested by showing that oral administration of Lactococcus lactis NZ9000 to rats resulted in a decrease in infiltration of pro-inflammatory leucocytes, mainly eosinophils and decreased lung IL-4 and IL-5 expression in the broncho-alveolar lavage and a reduced level of serum allergen-specific IgE [ 24 ]. Another study conducted in mice using Lactobacillus rhamnosus GR-1 significantly prevented airway hyperreactivity development and prevented microbiome disturbance in the asthmatic animals, supporting the existence of the gut–lung axis [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

Prevention and Management with Pro-, Pre and Synbiotics in Children with Asthma and Allergic Rhinitis: A Narrative Review

Meirlaen¹,

Levy²,

Vandenplas³

2021

Nutrients

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Allergic diseases including allergic rhinitis and asthma are increasing in the developing world, related to a westernizing lifestyle, while the prevalence is stable and decreasing in the industrialized world. This paper aims to answer the question if prevention and/or treatment of allergic rhinitis and asthma can be achieved by administrating pro-, pre- and/or synbiotics that might contribute to stabilizing the disturbed microbiome that influences the immune system through the gut–lung axis. We searched for relevant English articles in PubMed and Google Scholar. Articles interesting for the topic were selected using subject heading and key words. Interesting references in included articles were also considered. While there is substantial evidence from animal studies in well controlled conditions that selected probiotic strains may offer benefits in the prevention of wheezing and asthma, outcomes from clinical studies in infants (including as well pre- and postnatal administration) are disappointing. The latter may be related to the multiple confounding factors such as environment, strain selection and dosage, moment of administration and genetic background. There is little evidence to recommend administration of pro, pre- or synbiotics in the prevention of asthma and allergic rhinitis in children.

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Section: Resultsmentioning

confidence: 99%

Prevention and Management with Pro-, Pre and Synbiotics in Children with Asthma and Allergic Rhinitis: A Narrative Review

Meirlaen¹,

Levy²,

Vandenplas³

2021

Nutrients

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“…For example, various Lactobacillus rhamnosus strains have shown anti-inflammatory effects in the airway in murine models, suppressing the total immunoglobulin E (IgE) production and pulmonary eosinophil-associated inflammation ( 15 ). Other strains, e.g., Bifidobacterium breve M-16 ( 16 ), Lactococcus lactis NZ9000 ( 17 ), and Bifidobacterium lactis Bb-12 ( 18 ), could suppress asthmatic symptoms. On the contrary, unlike in animal experiments, application of probiotics in managing asthma has not achieved consistent results in human clinical trials.…”

Section: Introductionmentioning

confidence: 99%

Adjunctive Probiotics Alleviates Asthmatic Symptoms via Modulating the Gut Microbiome and Serum Metabolome

Liu

et al. 2021

Microbiol Spectr

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The human gut microbiota has a potential effect on the pathogenesis of asthma and is closely related to the disease phenotype. Our trial has demonstrated that co-administering Probio-M8 synergized with conventional therapy to alleviate asthma symptoms. The findings of the present study provide new insights into the pathogenesis and treatment of asthma, mechanisms of novel therapeutic strategies, and application of probiotics-based therapy.

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“…Lastly, the roles of probiotics, prebiotics, and synbiotics appear to reduce the respiratory inflammatory pattern via the gut-lung axis, but their role in the prevention and treatment of asthma is questionable due to the connection between the gut and lung microbiomes [303][304][305][306][307][308][309][310][311][312][313][314][315][316]319]. In order to describe the role of dietary supplements (such as fish oil, vitamins, probiotics, prebiotics, and synbiotics) in preventing and improving asthma management in children, further studies are necessary.…”

Section: Discussionmentioning

confidence: 99%

“…Prebiotics are substrates, such as inulin, fructooligosaccharides, and galacto-oligosaccharides, used by the host's microbiota with a beneficial effect. Synbiotics include live microorganisms and energetic substrates that can have a beneficial effect on the body [305][306][307].…”

Section: Probiotics Prebiotics and Synbiotics: Prevention And Treatmentmentioning

confidence: 99%

Pediatric Obesity-Related Asthma: The Role of Nutrition and Nutrients in Prevention and Treatment

et al. 2021

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Childhood obesity rates have dramatically risen in numerous countries worldwide. Obesity is likely a factor in increased asthma risk, which is already one of the most widespread chronic respiratory pathologies. The pathogenic mechanism of asthma risk has still not yet been fully elucidated. Moreover, the role of obesity-related inflammation and pulmonary overreaction to environmental triggers, which ultimately result in asthma-like symptoms, and the importance of dietary characteristics is well recognized. Diet is an important adjustable element in the asthma development. Food-specific composition of the diet, in particular fat, sugar, and low-quality nutrients, is likely to promote the chronic inflammatory state seen in asthmatic patients with obesity. An unbalanced diet or supplementation as a way to control asthma more efficiently has been described. A personalized dietary intervention may improve respiratory symptoms and signs and therapeutic response. In this narrative review, we presented and discussed more recent literature on asthma associated with obesity among children, focusing on the risk of asthma among children with obesity, asthma as a result of obesity focusing on the role of adipose tissue as a mediator of systemic and local airway inflammation implicated in asthma regulation, and the impact of nutrition and nutrients in the development and treatment of asthma. Appropriate early nutritional intervention could possibly be critical in preventing and managing asthma associated with obesity among children.

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<b><i>Lactococcus lactis</i></b> NZ9000 Prevents Asthmatic Airway Inflammation and Remodelling in Rats through the Improvement of Intestinal Barrier Function and Systemic TGF-β Production

Cited by 22 publications

References 64 publications

Prevention and Management with Pro-, Pre and Synbiotics in Children with Asthma and Allergic Rhinitis: A Narrative Review

Prevention and Management with Pro-, Pre and Synbiotics in Children with Asthma and Allergic Rhinitis: A Narrative Review

Adjunctive Probiotics Alleviates Asthmatic Symptoms via Modulating the Gut Microbiome and Serum Metabolome

Pediatric Obesity-Related Asthma: The Role of Nutrition and Nutrients in Prevention and Treatment

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