&lt;b&gt;P2Y purinoceptors mediate ATP-induced changes in intracellular calcium and amylase release in acinar cells of mouse parotid &lt;/b&gt;&lt;b&gt;glands &lt;/b&gt;

Moriguchi-Mori, Kasumi; Higashio, Hisao; Isobe, Kanako; Kumagai, Miho; Sasaki, Kana; Satoh, Yuichi; Kuji, Akiyoshi; Saino, Tomoyuki

doi:10.2220/biomedres.37.37

Cited by 3 publications

(2 citation statements)

References 60 publications

(75 reference statements)

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“…Furthermore, the relevance of variable extracellular ATP was also determined by incubation with the non‐hydrolyzable ATP analogue ATP‐γ‐S (5 and 50 μM) 37 . The participation of P2Y receptors in αENaC regulation by EVs was assessed using suramin (50 μM) 38 …”

Section: Methodsmentioning

confidence: 99%

Extracellular vesicles regulate purinergic signaling and epithelial sodium channel expression in renal collecting duct cells

et al. 2021

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Section: Methodsmentioning

confidence: 99%

Extracellular vesicles regulate purinergic signaling and epithelial sodium channel expression in renal collecting duct cells

et al. 2021

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“…However, these data should be confirmed in mice and humans. Conversely, activation of P2Y 2 receptors, initially identified in a cell line of human salivary gland cells and subsequently in other epithelia, seems to contribute to saliva secretion [ 74 ]. However, data are not univocal and further research is warranted to clarify the role of these receptors.…”

Section: Purinergic Signaling In the Salivary Glandsmentioning

confidence: 99%

Purinergic Signaling in Oral Tissues

Zuccarini

Giuliani

Ronci

et al. 2022

IJMS

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The role of the purinergic signal has been extensively investigated in many tissues and related organs, including the central and peripheral nervous systems as well as the gastrointestinal, cardiovascular, respiratory, renal, and immune systems. Less attention has been paid to the influence of purines in the oral cavity, which is the first part of the digestive apparatus and also acts as the body’s first antimicrobial barrier. In this review, evidence is provided of the presence and possible physiological role of the purinergic system in the different structures forming the oral cavity including teeth, tongue, hard palate, and soft palate with their annexes such as taste buds, salivary glands, and nervous fibers innervating the oral structures. We also report findings on the involvement of the purinergic signal in pathological conditions affecting the oral apparatus such as Sjögren’s syndrome or following irradiation for the treatment of head and neck cancer, and the use of experimental drugs interfering with the purine system to improve bone healing after damage. Further investigations are required to translate the results obtained so far into the clinical setting in order to pave the way for a wider application of purine-based treatments in oral diseases.

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The imprint of salivary secretion in autoimmune disorders and related pathological conditions

Bhattarai

Junjappa

Handigund

et al. 2018

Autoimmunity Reviews

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Xerostomia is a state of oral dryness associated with salivary gland dysfunction and is induced by stress, radiation and chemical therapy, various systemic and autoimmune diseases, and specific medications. Fluid secretion is interrupted by the stimulation of neurotransmitter-induced increase in cytosolic calcium ([Ca]) in salivary gland acinar cells, prompting the mobilization of ion channels and their transporters. Salivary fluid and protein secretion are principally dependent on parasympathetic and sympathetic nerves. Various inflammatory cytokines allied with lymphocytic infiltration cause glandular damage and Sjogren's syndrome, an autoimmune exocrinopathy associated with hyposalivation. A defect in IPRs, a major calcium release channel, prompts inadequate agonist-induced [Ca] in acinar cells and deters salivary flow. The store-operated calcium entry-mediated Ca movement into the acini activates K and Cl channels, which further opens a water channel protein, aquaporin-5, and triggers the release of fluid secretion from the salivary glands. The cellular mechanism of salivary gland dysfunction and hyposalivation has not yet been elucidated. In this review, we focused mainly on the proteins responsible for deficient saliva, the correlation between inflammation and salivation, autoimmune disorders and other ailments or complications associated with hyposalivation.

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<b>P2Y purinoceptors mediate ATP-induced changes in intracellular calcium and amylase release in acinar cells of mouse parotid </b><b>glands </b>

Cited by 3 publications

References 60 publications

Extracellular vesicles regulate purinergic signaling and epithelial sodium channel expression in renal collecting duct cells

Extracellular vesicles regulate purinergic signaling and epithelial sodium channel expression in renal collecting duct cells

Purinergic Signaling in Oral Tissues

The imprint of salivary secretion in autoimmune disorders and related pathological conditions

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