&lt;em&gt;In Vivo&lt;/em&gt; Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Deel, Elza van; Ridwan, Yanto; Vliet, J. Nicole van; Belenkov, Sasha; Essers, Jeroen

doi:10.3791/53603

Cited by 14 publications

(14 citation statements)

References 49 publications

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“…Of note, we found significant inter-segmental and inter-regional differences in the septum itself, which emphasizes the need for segmental reference values and confirms previous reports [27]. These findings are in agreement with the tight territorial distribution of different functional parameters (perfusion, metabolism, contraction) that were found by microCT analysis in a mouse model reported in the literature [28]. The variability of blood supply to septal segments 8 and 9 from the left anterior descending and the right coronary arteries could also contribute to this discrepancy.…”

Section: Discussionsupporting

confidence: 92%

Cardiac T2 mapping: robustness and homogeneity of standardized in-line analysis

Wiesmueller

Wuest

Heiß

et al. 2020

Journal of Cardiovascular Magnetic Resonance

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Background and purpose: Interpretation of T2 values remains difficult due to limited comparability across hardware and software systems and the lack of validated measurement recommendations for the number and orientation of mandatory slices. Our aims were to provide a standardized comparison of intra-and inter-individual T2 values in the short and long axes and to investigate inter-scanner reproducibility. Method and materials: Ninety cardiovascular magnetic resonance (CMR) studies in 30 healthy subjects were performed with three identical 1.5 T CMR scanners (same hardware and software) using a balanced steady-state free precession (bSSFP) gradient echo sequence in three short axis (SAx) and three long axis (LAx) views. A commercially available T2 mapping software package of the latest generation with automatic in-line motion correction was used for acquisition. Regions of interest were manually drawn in each of the 16 myocardial segments according to the American Heart Association (AHA) model in three SAx and three LAx acquisitions. Analysis of inter-scanner, intersegmental, intra-segmental, interregional and inter-level differences was performed. Results: Inter-scanner reproducibility was high and the mean myocardial T2 value for all evaluated segments was 45.7 ± 3.4 ms. Significant inter-segmental variations of mean T2 values were found. Mean intra-segmental T2 values were comparable between LAx and SAx acquisitions in 72%. Significantly higher T2 values were found in apical segments and a significant disparity among different regions was found for SAx and LAx orientations. Conclusion: Standardized cardiac T2 mapping is highly reproducible on identical CMR systems. T2 values vary significantly between single heart segments, regions, levels, and axes in young, healthy subjects.

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Section: Discussionsupporting

confidence: 92%

Cardiac T2 mapping: robustness and homogeneity of standardized in-line analysis

Wiesmueller

Wuest

Heiß

et al. 2020

Journal of Cardiovascular Magnetic Resonance

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“…for postsurgical analgesia. Sham, MI, and TAC surgery were performed as previously described [ 24 , 41 ]. After recovery from surgery, all exercise groups were exposed to eight weeks of voluntary wheel running ( Figure 1 B).…”

Section: Methodsmentioning

confidence: 99%

Exercise Training Has Contrasting Effects in Myocardial Infarction and Pressure Overload Due to Divergent Endothelial Nitric Oxide Synthase Regulation

Deel

Octavia

Waard

et al. 2018

IJMS

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The beneficial effects of exercise training (EX) on cardiac pathology are well recognized. Previously, we found that the effects of EX on cardiac dysfunction in mice critically depend on the underlying etiology. EX exerted beneficial effects after myocardial infarction (MI); however, cardiac pathology following pressure overload produced by transverse aortic constriction (TAC) was aggravated by EX. In the presented study, we investigated whether the contrasting effects of EX on cardiac dysfunction can be explained by an etiology-specific response of endothelial nitric oxide (NO) synthase (eNOS) to EX, which divergently affects the balance between nitric oxide and superoxide. For this purpose, mice were exposed to eight weeks of voluntary wheel running or sedentary housing (SED), immediately after sham, MI, or TAC surgery. Left ventricular (LV) function was assessed using echocardiography and hemodynamic measurements. EX ameliorated LV dysfunction and remodeling after MI, but not following TAC, in which EX even aggravated fibrosis. Strikingly, EX attenuated superoxide levels after MI, but exacerbated NOS-dependent superoxide levels following TAC. Similarly, elevated eNOS S-glutathionylation and eNOS monomerization, which were observed in both MI and TAC, were corrected by EX in MI, but aggravated by EX after TAC. Additionally, EX reduced antioxidant activity in TAC, while it was maintained following EX in MI. In conclusion, the present study shows that EX mitigates cardiac dysfunction after MI, likely by attenuating eNOS uncoupling-mediated oxidative stress, whereas EX tends to aggravate cardiac dysfunction following TAC, likely due to exacerbating eNOS-mediated oxidative stress.

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“…4). The LV mass was calculated from the product of the LV myocardial volume and the density of the myocardial tissue (1.04 g/cm 3 ) [23].…”

Section: Cardiac Remodellingmentioning

confidence: 99%

Cardiac remodelling following thoracic endovascular aortic repair for descending aortic aneurysms

Bakel

Arthurs

Nauta

et al. 2018

European Journal of Cardio-Thoracic Surgery

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OBJECTIVES Current endografts for thoracic endovascular aortic repair (TEVAR) are much stiffer than the aorta and have been shown to induce acute stiffening. In this study, we aimed to estimate the impact of TEVAR on left ventricular (LV) stroke work (SW) and mass using a non-invasive image-based workflow. METHODS The University of Michigan database was searched for patients treated with TEVAR for descending aortic pathologies (2013–2016). Patients with available pre-TEVAR and post-TEVAR computed tomography angiography and echocardiography data were selected. LV SW was estimated via patient-specific fluid–structure interaction analyses. LV remodelling was quantified through morphological measurements using echocardiography and electrocardiographic-gated computed tomography angiography data. RESULTS Eight subjects were included in this study, the mean age of the patients was 68 (73, 25) years, and 6 patients were women. All patients were prescribed antihypertensive drugs following TEVAR. The fluid–structure interaction simulations computed a 26% increase in LV SW post-TEVAR [0.94 (0.89, 0.34) J to 1.18 (1.11, 0.65) J, P = 0.012]. Morphological measurements revealed an increase in the LV mass index post-TEVAR of +26% in echocardiography [72 (73, 17) g/m2 to 91 (87, 26) g/m2, P = 0.017] and +15% in computed tomography angiography [52 (46, 29) g/m2 to 60 (57, 22) g/m2, P = 0.043]. The post- to pre-TEVAR LV mass index ratio was positively correlated with the post- to pre-TEVAR ratios of SW and the mean blood pressure (ρ = 0.690, P = 0.058 and ρ = 0.786, P = 0.021, respectively). CONCLUSIONS TEVAR was associated with increased LV SW and mass during follow-up. Medical device manufacturers should develop more compliant devices to reduce the stiffness mismatch with the aorta. Additionally, intensive antihypertensive management is needed to control blood pressure post-TEVAR.

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<em>In Vivo</em> Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Cited by 14 publications

References 49 publications

Cardiac T2 mapping: robustness and homogeneity of standardized in-line analysis

Cardiac T2 mapping: robustness and homogeneity of standardized in-line analysis

Exercise Training Has Contrasting Effects in Myocardial Infarction and Pressure Overload Due to Divergent Endothelial Nitric Oxide Synthase Regulation

Cardiac remodelling following thoracic endovascular aortic repair for descending aortic aneurysms

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