<i>Acanthopanax senticosus</i> Root Extract Exerts Dual Action on Mouse Ileal Smooth Muscle Function, Leading to Modulation of Gastrointestinal Motility

MS/MS molecular networking‐guided in‐depth profiling of triterpenoid saponins from the fruit of Eleutherococcus senticosus and their neuroprotectivity evaluation

“…1,2 Traditionally, E. senticosus is used as a classical adaptogen, a medicinal plant that increases the non-specific inter-systemic antistress effects of the organism. 3,4 As a natural herbal medicine with tonifying, sleepstrengthening, and tranquilizing effects, 5 it was recorded in the 2020 edition of the Chinese Pharmacopoeia and the 14th edition of the Russian Pharmacopoeia, 4,6 and it was approved by the European Medicines Agency (EMA) in 2014. 7 According to clinical trials, E. senticosus has significant beneficial effects on cognitive function and physical and mental endurance, and it exerts antidepressant and antifatigue effects.…”

“…7 According to clinical trials, E. senticosus has significant beneficial effects on cognitive function and physical and mental endurance, and it exerts antidepressant and antifatigue effects. 3,4,8 Modern pharmacology studies showed that E. senticosus fruit (ESF) can soothe the neural system, restoring vigor and improving sleep. 9,10 Various biological effects of ESF have been reported, including antioxidant, 11 antibacterial, 12 immunomodulatory, 13 antiobesity, 14 and tonic effects, 13,15 which could be attributed to the constituents of ESF, including triterpenoid saponins (TS), [16][17][18] flavonoids, 19 and phenolic acids.…”

“…(synonymous with Acanthopanax senticosus , family Araliaceae), also known as Siberian ginseng or eleuthero, is distributed mainly in cold areas, such as southeastern Russia, northern China, Siberia, Japan, and North Korea 1,2 . Traditionally, E. senticosus is used as a classical adaptogen, a medicinal plant that increases the non‐specific inter‐systemic antistress effects of the organism 3,4 . As a natural herbal medicine with tonifying, sleep‐strengthening, and tranquilizing effects, 5 it was recorded in the 2020 edition of the Chinese Pharmacopoeia and the 14th edition of the Russian Pharmacopoeia, 4,6 and it was approved by the European Medicines Agency (EMA) in 2014 7 .…”

“…As a natural herbal medicine with tonifying, sleep‐strengthening, and tranquilizing effects, 5 it was recorded in the 2020 edition of the Chinese Pharmacopoeia and the 14th edition of the Russian Pharmacopoeia, 4,6 and it was approved by the European Medicines Agency (EMA) in 2014 7 . According to clinical trials, E. senticosus has significant beneficial effects on cognitive function and physical and mental endurance, and it exerts antidepressant and antifatigue effects 3,4,8 . Modern pharmacology studies showed that E. senticosus fruit (ESF) can soothe the neural system, restoring vigor and improving sleep 9,10 .…”

Pharmacological effects of Eleutherococcus senticosus on the neurological disorders

“…According to the records in classic publications and pharmacological reports, the traditional uses of ES (Table 1) Neural calming and vitality replenishing effects are usually recognized as a major function of ES. According to the records, the roots and rhizomes of Ciwujia were used as tonifying, replenishing, heart-nourishing, and tranquilizing herbal medicines (Miyauchi-Wakuda et al, 2020). Owing to its tonic effect, ES has been highly praised by the Bancao Gangmu (Encyclopedia of Herbs, China) as a god-given herbal for improving appetite and physical fitness, as well as for enhancing memory when eating it regularly for a long time (Li, 2003).…”