Anti-diarrheal therapeutic potential of diminazene aceturate stimulation of the ACE II/Ang-(1–7)/Mas receptor axis in mice: A trial study

Souza, Luan Kelves Miranda de; Nogueira, Kerolayne M.; Araújo, Thiago Souza; Sousa, Nayara Alves de; Sousa, Francisca Beatriz M.; Oliveira, Ana Patrícia de; Sales, Thiago M.; Silva, Karine; Rocha, Talita Magalhães; Leal, Luzia Kalyne Almeida Moreira; Magalhães, Pedro J.C.; Souza, Marcellus H.; Medeiros, Jand Venes Rolim

doi:10.1016/j.bcp.2021.114500

Cited by 4 publications

(1 citation statement)

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“…In conclusion, DIZE administration after radiation injury promoted multiorgan recovery without overt tissue toxicity. Whether DIZE could alleviate some of the associated sequelae observed in long COVID-18 [ 164 ] (postural orthostatic tachycardia syndrome, neurological dysfunction signalling, immune dysregulation, microbiota disruption, and erectile dysfunction [ 165 , 166 ]) in animals or humans is yet to be proposed.…”

Section: Diarylamidines Serine Proteasesmentioning

confidence: 99%

COVID-19 and Diarylamidines: The Parasitic Connection

Hulme

2023

IJMS

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As emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants (Omicron) continue to outpace and negate combinatorial vaccines and monoclonal antibody therapies targeting the spike protein (S) receptor binding domain (RBD), the appetite for developing similar COVID-19 treatments has significantly diminished, with the attention of the scientific community switching to long COVID treatments. However, treatments that reduce the risk of “post-COVID-19 syndrome” and associated sequelae remain in their infancy, particularly as no established criteria for diagnosis currently exist. Thus, alternative therapies that reduce infection and prevent the broad range of symptoms associated with ‘post-COVID-19 syndrome’ require investigation. This review begins with an overview of the parasitic–diarylamidine connection, followed by the renin-angiotensin system (RAS) and associated angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSSR2) involved in SARS-CoV-2 infection. Subsequently, the ability of diarylamidines to inhibit S-protein binding and various membrane serine proteases associated with SARS-CoV-2 and parasitic infections are discussed. Finally, the roles of diarylamidines (primarily DIZE) in vaccine efficacy, epigenetics, and the potential amelioration of long COVID sequelae are highlighted.

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Section: Diarylamidines Serine Proteasesmentioning

confidence: 99%