&lt;i&gt;Clostridium butyricum&lt;/i&gt; affects nutrition and immunology by modulating gut microbiota

Yamamoto, Miyako; Ohmori, Harunori; Takei, Daisuke; Matsumoto, Tomio; Takemoto, Masumi; Ikeda, Masanobu; Sumimoto, Ryo; Kobayashi, Tsuyoshi; Ohdan, Hideki

doi:10.12938/bmfh.2021-046

Cited by 10 publications

(6 citation statements)

References 66 publications

(75 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, we found a higher abundance of Clostridium and a lower abundance of Bacteroides at the genus level in the CB group, which may partially suggest CB colonization. In comparison to patients without CB treatment, the α-diversity index of gut microbiota was more abundant in patients who received CB 50 . Mao et al showed that CB increased the abundance of Bifidobacterium , Lactobacillus , and Lactococcus species in the gut microbiome 51 .…”

Section: Discussionmentioning

confidence: 83%

Immunoregulatory role of the gut microbiota in inflammatory depression

Liu,

Wang

et al. 2024

Nat Commun

View full text Add to dashboard Cite

Inflammatory depression is a treatment-resistant subtype of depression. A causal role of the gut microbiota as a source of low-grade inflammation remains unclear. Here, as part of an observational trial, we first analyze the gut microbiota composition in the stool, inflammatory factors and short-chain fatty acids (SCFAs) in plasma, and inflammatory and permeability markers in the intestinal mucosa of patients with inflammatory depression (ChiCTR1900025175). Gut microbiota of patients with inflammatory depression exhibits higher Bacteroides and lower Clostridium, with an increase in SCFA-producing species with abnormal butanoate metabolism. We then perform fecal microbiota transplantation (FMT) and probiotic supplementation in animal experiments to determine the causal role of the gut microbiota in inflammatory depression. After FMT, the gut microbiota of the inflammatory depression group shows increased peripheral and central inflammatory factors and intestinal mucosal permeability in recipient mice with depressive and anxiety-like behaviors. Clostridium butyricum administration normalizes the gut microbiota, decreases inflammatory factors, and displays antidepressant-like effects in a mouse model of inflammatory depression. These findings suggest that inflammatory processes derived from the gut microbiota can be involved in neuroinflammation of inflammatory depression.

show abstract

Section: Discussionmentioning

confidence: 83%

Immunoregulatory role of the gut microbiota in inflammatory depression

Liu,

Wang

et al. 2024

Nat Commun

View full text Add to dashboard Cite

show abstract

“…Indeed, we did find a higher abundance of Clostridium and lower abundance of Bacteroides at the genus level in the CB group, which may partially suggest the colonization of CB. In comparison to patients without CB treatment, the α-diversity index of gut microbiota was more abundant in patients who received CB 60 .…”

Section: Discussionmentioning

confidence: 83%

Gut microbiota characteristics and its immunoregulatory role in inflammatory depression: joint clinical and animal data

Zhang

Liu

et al. 2023

Preprint

View full text Add to dashboard Cite

Previous studies have reported that inflammatory depression is a treatment-resistant depression subtype and that disturbed gut microbiota may be the source of low-grade inflammation. But the gut microbiota’s features and its role of immunoregulation in this subtype of depression remains uncertain. We propose that Toll-like receptor 4 (TLR-4)/nuclear factor kappa-B (NF-κB) and the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome signaling pathway activated by disordered gut microbiota could contribute to intestinal and central inflammation in inflammatory depression. To test this hypothesis, we performed studies in both humans and mice. Gut microbiota composition in stool, inflammation factor and short chain fatty acid (SCFAs) in plasma, inflammatory and permeability marker in intestinal mucosa were analyzed in inflammatory depression patients. Then we performed fecal microbiota transplantation (FMT) and probiotic supplement to determine whether the behavioral phenotypes were linked with disturbed gut microbiota in inflammatory depression. Compared with non-inflammatory depression and HCs, the relative abundance of Bacteroides was significantly higher, and Clostridium was lower in inflammatory depression patients. Further, we found that SCFA-producing species increased with abnormal butanoate metabolism in the inflammatory depression patients following shotgun metagenomic sequencing. After FMT, gut microbiota in inflammatory depression increased inflammatory factors, those including as hs-CRP, TLR-4, NF-κB, NLRP3, Caspase-1, Interleukin-1β (IL-1β), and iba-1. We also found that intestinal mucosal permeability increased in recipient mice with depressive and anxiety-like behaviors. Clostridium butyricum treatment can normalize the gut microbiota, repair “gut leak,” decrease peripheral and central inflammatory factors, and have an antidepressant-like effect in the mouse model inflammatory depression. Together, our study findings indicate that inflammatory depression patients have increased pro-inflammatory genera and decreased SCFA-producing genera. Gut microbiota-derived inflammatory processes mediated by TLR-4/NF-κB–NLRP3 inflammasome signaling pathway are involved in neuroinflammation in inflammatory depression.

show abstract

“…It can also use carbohydrates in the large intestine to ferment short-chain fatty acids and repair intestinal mucosa (9, 10). In addition, CB can reduce the PH value of the intestinal environment, inhibit intestinal inflammatory response, and strengthen intestinal immune function and antioxidant capacity (11,12). CB is resistant to most antibiotics (13).…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary Clostridium butyricum on the growth performance, digestion, and intestinal health of spotted sea bass (Lateolabrax maculatus)

Kong

Zhou

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Clostridium butyricum (CB) is known to promote growth, enhance immunity, promote digestion, and improve intestinal health. In this study, we investigated the effects of CB in the feed on growth performance, digestion, and intestinal health of juvenile spotted sea bass. To provide a theoretical basis for the development and application of CB in the feed of spotted sea bass, a total of 450 spotted sea bass with an initial body weight of (9.58 ± 0.05) g were randomly divided into six groups. Gradient levels with 0, 0.1%, 0.2%, 0.3%, 0.4%, and 0.5% of CB (1×109 cfu/g) were supplemented into diets, designated as CC, CB1, CB2, CB3, CB4, and CB5, respectively. Each group was fed for 54 days. Our results suggest that dietary 0.2% and 0.3% of CB can significantly increase the weight gain (WG) and specific growth rate (SGR) of spotted sea bass. The addition of CB significantly increased intestinal amylase activity, intestinal villus length, intestinal villus width, and intestinal muscle thickness. Similarly, CB supplementation increased the expression of tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8). Sequence analysis of the bacterial 16S rDNA region showed that dietary CB altered the intestinal microbiota profile of juvenile spotted sea bass, increasing the dominant bacteria in the intestine and decreasing the harmful bacteria. Overall, dietary addition of CB can improve growth performance, enhance intestinal immunity, improve intestinal flora structure, and comprehensively improve the health of spotted sea bass.

show abstract

<i>Clostridium butyricum</i> affects nutrition and immunology by modulating gut microbiota

Cited by 10 publications

References 66 publications

Immunoregulatory role of the gut microbiota in inflammatory depression

Immunoregulatory role of the gut microbiota in inflammatory depression

Gut microbiota characteristics and its immunoregulatory role in inflammatory depression: joint clinical and animal data

Effects of dietary Clostridium butyricum on the growth performance, digestion, and intestinal health of spotted sea bass (Lateolabrax maculatus)

Contact Info

Product

Resources

About