&lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Vivo&lt;/i&gt; Antioxidant Potential of Hydromethanolic Extract of &lt;i&gt;Phoenix dactylifera&lt;/i&gt; Fruits

Naskar, Sagar; Islam, Aminul; Mazumder, Upal Kanti; Saha, Prerona; Haldar, Pallab Kanti; Gupta, Malaya

doi:10.3329/jsr.v2i1.2643

Cited by 86 publications

(62 citation statements)

References 10 publications

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“…Besides it also exhibits free radical scavenging properties by either through scavenging or chelating process (Usmani, 2013, Ebrahimzadeh et al, 2008, Roy et al, 2013. Flavonoids are large class of benzo-pyrone derivatives, ubiquitous in plants exhibit antioxidant activity (Naskar et al, 2010). Total flavonoid content is expressed as μg of quercetin equivalents (QE)/mg of extract.…”

Section: Estimation Of Total Flavonoid Contentmentioning

confidence: 99%

In-vitro antioxidative potential of methanolic aerial extracts from three ethnomedicinal plants of Assam: A Comparative Study

Mahato¹,

Kakoti²,

Borah³

et al. 2015

J App Pharm Sci

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Antioxidants are the substances that neutralize free radicals or their actions. The traditional antioxidant phytochemicals from plants have been reported to inhibit the propagation of free radical reactions and to protect the human body from disease. The use of synthetic antioxidants has always been questioned because of their toxicity therefore researches are being carried out on plants nowadays to bring out the potent natural antioxidants. With this intent three ethnomedicinal plants of Assam viz., Calamus leptospadix Griff., Heliotropium indicum Linn., Lasia spinosa Lour. were explored with a view to evaluate their in-vitro antioxidative potentials. The methanolic aerial extracts were studied for phytochemical analysis and antioxidative properties by different invitro assays: DPPH radical scavenging method, Nitric oxide radical scavenging activity, Hydrogen peroxide radical scavenging activity, Total phenolic content and Total flavonoid content. The percentage of inhibition was calculated by comparing the absorbance values of the control and test samples. The study conducted revealed that methanolic extract of Calamus leptospadix (CL) exhibited the highest DPPH radical scavenging activity (IC50 value of 29 ± 3.24 μg/ml), Nitric oxide radical scavenging activity (233.33 ± 3.54 μg/ml), Total phenolic content (8.02 ± 0.32 μg/ml expressed as gallic acid equivalents) and Total flavonoid contents (61.71 ± 1.16 μg/ml expressed as quercetin equivalents). Methanolic extract of Lasia spinosa (LS) showed highest hydrogen peroxide radical scavenging activity (IC50 value of 221.89 ± 2.14 μg/ml). The results obtained in the present study indicate that aerial parts of Calamus leptospadix have potent, Lasia spinosa have moderate and Heliotropium indicum (HI) have mild antioxidant and free radical scavenging activity.

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Section: Estimation Of Total Flavonoid Contentmentioning

confidence: 99%

In-vitro antioxidative potential of methanolic aerial extracts from three ethnomedicinal plants of Assam: A Comparative Study

Mahato¹,

Kakoti²,

Borah³

et al. 2015

J App Pharm Sci

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“…Phenolic compounds like flavonoïds and tannins are good antioxidant substances which have been reported to have biological activities and prevent or control oxidative stress related disorders. 39 The crude extract tested negative to alkaloids.This finding is contrary to report of Conserva and Ferreira et al in 2012 that alkaloids were present in species of Borreria. 40 Previous studies indicated that many phenolic and steroidal compounds possessed anti-plasmodial activities.…”

Section: Discussionmentioning

confidence: 99%

Antimalarial and Antioxidant Potentials of Extract and Fractions of Aerial part of Borreria ocymoides DC (Rubiaceae).

Adesegun¹,

Orabueze²,

Coker³

2017

Phcog J

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Introduction: Borreria ocymoides (Burm F) DC is a weak, erect and decumbent herb that has several folkloric, ethno medicinal uses and is included in antimalarial preparations by some traditional healers. It is also used in treatment of ring worm, eczema and microbial infections. Objectives: To evaluate antimalarial activity of extract and fractions of Borreria ocymoides in Plasmodium berghei infected mice and to investigate their antioxidant activity using 1, 1-diphenyl-2-picryl-hydrazile (DPPH). Methods: The methanol extract of aerial part of B. ocymoides and the solvent fractions obtained from partition between organic solvents were assessed for antimalarial activity against chloroquine sensitive Plasmodium berghei NK65 infected mice using the suppressive and curative test procedures. Chloroquine (10 mg/ml) was used as positive control. The antioxidant activity was evaluated using DPPH radical scavenging ability and determination of total phenolic content. Results: The crude extract (250 and 500 mg kg-1) produced a dose dependent anti-plasmodial activity in the suppressive and curative tests. The chemo suppression activity was best in the ethyl acetate fraction (87.31%) and in the order ethyl acetate >dichloromethane > hexane > aqueous fraction. The DPPH radical scavenging activity of the extract increased with concentration. The antioxidant activity was less than ascorbic acid used as positive control. Oral administration up to 5 g/kg produced no noticeable deleterious effect 24 hours after dosing and up to 7 days afterwards. Conclusion:The results indicated that the extract has a potent anti-plasmodial activity against Plasmodium berghei and the activity seems to reside in the mid-polar fractions. Thus, the plant is a potential source of new antimalarial agents.

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“…Phoenix dactylifera is famous for its use in treating jaundice and in women before and after delivery in traditional medicine practice. Naskar et al (2010) reported that water-methanolic extract of date fruit possesses potent antioxidant effect and free radical scavenging activity in addition to its hepatoprotective effect. Date syrup can replace honey by 75% because of their similarity in sugar content.…”

Section: Hepatoprotectionmentioning

confidence: 99%

“…A hydromethanolic extract of P. dactylifera fruit showed high antioxidant activity, reducing power, free radical scavenging activity, the antioxidant potential was attributed to phytoconstituents (flavonoids, saponins, tannins, steroids) and vitamin C (Naskar et al, 2010). Furthermore, aqueous P. dactylifera extract was found to inhibit significantly the lipid peroxidation, protein oxidation and also exhibited a potent superoxide and hydroxyl radical scavenging activity in a dose dependent manner in vitro (Vyawahare et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Phoenix dactylifera linn as a potential novel anti-oxidant in treating major opioid toxicity.

Sani¹,

Bakar²,

Rohin³

et al. 2015

J App Pharm Sci

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<i>In Vitro</i> and <i>In Vivo</i> Antioxidant Potential of Hydromethanolic Extract of <i>Phoenix dactylifera</i> Fruits

Cited by 86 publications

References 10 publications

In-vitro antioxidative potential of methanolic aerial extracts from three ethnomedicinal plants of Assam: A Comparative Study

In-vitro antioxidative potential of methanolic aerial extracts from three ethnomedicinal plants of Assam: A Comparative Study

Antimalarial and Antioxidant Potentials of Extract and Fractions of Aerial part of Borreria ocymoides DC (Rubiaceae).

Phoenix dactylifera linn as a potential novel anti-oxidant in treating major opioid toxicity.

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