&lt;i&gt;In Vitro&lt;/i&gt; Antibacterial Activity of &lt;i&gt;Eclipta alba&lt;/i&gt; (L.) Hassk

Selvamani, S.; Balamurugan, S.

doi:10.18052/www.scipress.com/ilns.21.28

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…Eclipta alba L. is small branched annual herbaceous plant with a long history of traditional medicines uses in many countries, especially in tropical and subtropical regions. E. Alba is a source of coumestan-type compounds used in pharmaceutical formulations of medicines prescribed for the treatment of cirrhosis of the liver and infectious hepatitis [1]. E. alba is traditionally used for blackening, promoting hair growth, and strengthening the hair.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Antioxidant Activity of Eclipta Alba L.

Thenmozhi

Jayanthi²

2019

Asian J Pharm Clin Res

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Objective: Earlier various studies on pharmacological and therapeutic properties of Eclipta alba L. have been reported. The present investigation is on phytochemical screening and antioxidant activity of E. alba L. using different solvent extracts. Method: The shade-dried and grounded E. alba L. plant materials were treated with petroleum ether, chloroform, ethyl acetate, ethanol, methanol, and water (aqueous) solvents. The extracted residue was then dissolved in dimethylsulfoxide and further used for phytochemical screening and antioxidant studies. Results: E. alba L. on different solvent extract, the extractive yield was higher in methanol (14.22±0.99% w/w). The phytochemical screening analysis showed high number of secondary metabolites in the aqueous extract compared to other solvent studied. The metabolite flavonoids, phenols, and tannins are likely to be antioxidant potential compound. Hence, further, the total flavonoid content determination showed high of 0.875±0.020 μg/g in methanol extract. Further antioxidant property of E. alba L. was studied by method such as1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, nitric oxide scavenging activity, metal chelating activity, and superoxide dismutase activity which showed high antioxidant potency with IC50 values of 62.76±0.63 μg/ml, 96.24±0.34 μg/ml, 72.29±0.61 μg/ml, and 108.40±0.52 μg/ml, respectively, in the petroleum ether extract. Conclusion: From the present study, the substantiate result of antioxidant studies has been obtained from petroleum ether extract . Furthermore the extractive value and flavonoid content was observed to be high in methanol extract. The antioxidant potency of E. alba L. was found to be high in petroleum ether extract compared to other solvent studied.

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Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Antioxidant Activity of Eclipta Alba L.

Thenmozhi

Jayanthi²

2019

Asian J Pharm Clin Res

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Antibacterial Potency of Extracted Essential Oils of Some Plant Species against Common Gram-Positive and Gram-Negative Bacteria

Zaman

2021

King Khalid University Journal of Health Sciences

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Background: In the last decades, due to the rapid emergence of multidrug resistant pathogens, the antibiotic-resistance phenomenon has become a global health crisis. Therefore, there is a need to find new remedies against pathogenic microbes. Objectives: The main intention of this research was to appraise the antibacterial potency of extracted essential oils (EEOs) from various plant species versus human disease-causing bacterial strains. Materials and Methods: Antibacterial and bactericidal activity of EEOs was tested on human disease-causing strains which included Gram-positive as well as Gram-negative bacteria. Antibacterial analysis for various extracts of the different plants was performed by utilizing the method of disc diffusion and deduction of minimum inhibitory concentration (MIC) by microbroth dilution assays of the EEOs against the bacterial strains. Standard antibiotics (amoxicillin, metronidazole, rifampicin, clarithromycin, oxacillin, and clindamycin) were used to compare with EEO antibacterial activity. Results: Eclipta alba EEO was most effective against Streptococcus Pyogenes (2.06 ± 0.15), Neisseria gonorrhoeae (1.50 ± 0.20), Streptococcus aureus (0.05 ± 0.02), and Pseudomonas aeruginosa (4.56 ± 0.25). Leucas linifolia EEO was most effective against E. coli (3.13 ± 0.25) and Klebsiella Pneumoniae (4.33 ± 0.23). Bactericidal activity EEO from E. alba with minimum bactericidal concentration (MBC) ranged from 0.11 ± 0.03 to 10.60 ± 0.55; Atriplex hortensis (8.73 ± 2.62–12.07 ± 0.65); Hedyotis scandens (9.13 ± 0.50–15.30 ± 0.43); L. linifolia (0.94 ± 0.05–10.73 ± 0.20); Murraya koenigii (9.0 ± 0.55–12.90 ± 0.18); and Phlogacanthus thyrsiflorus (5.96 ± 1.15–13.0 ± 0.52). Bactericidal activity E. alba EEO was highest against S. Pyogenes (4.06 ± 0.15), N. gonorrhoeae (3.06 ± 0.40), and S. aureus (0.11 ± 0.03). L. linifolia EEO was most effective against P. aeruginosa (0.94 ± 0.05) and K. Pneumoniae (8.73 ± 0.41). Against E. coli (5.96 ± 1.15), the bactericidal activity of P. thyrsiflorus EEO was most effective. Conclusions: Comparison to the antibacterial activity of EEOs from six different plant species used in the study was more effective than the tested antibiotics. MIC and MBC values show that E. alba EEO plant species was the most effective against the tested human pathogenic bacterial strains.

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<i>In Vitro</i> Antibacterial Activity of <i>Eclipta alba</i> (L.) Hassk

Cited by 2 publications

References 7 publications

Phytochemical Screening and Antioxidant Activity of Eclipta Alba L.

Phytochemical Screening and Antioxidant Activity of Eclipta Alba L.

Antibacterial Potency of Extracted Essential Oils of Some Plant Species against Common Gram-Positive and Gram-Negative Bacteria

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