&lt;i&gt;In vitro&lt;/i&gt; antiplasmodial properties of &lt;i&gt;Flacourtia flavescens&lt;/i&gt; willd. (&lt;i&gt;Flacourtiaceae&lt;/i&gt;) and &lt;i&gt;Rytigynia canthioides&lt;/i&gt; (benth.) Robyns (rubiaceae)

Djikpo-Tchibozo, M. A.; Karou, SD; Sanon, Souleymane; Toukourou, Fatiou; Souza, Comlan de

doi:10.4314/ajtcam.v8i1.60527

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…Many antimalarial investigations have also been done on plants used traditionally to treat infectious diseases with satisfactory results. This was demonstrated by results achieved with numerous studies on species from Benin Pharmacopoeia (Bero et al, 2013;Attioua et al, 2012;Djikpo-Tchibozo et al, 2011). Unfortunately, empirical and traditional knowledge are not registered and disappear over time.…”

Section: Introductionmentioning

confidence: 99%

Ethnobotanical survey of medicinal plants used in malaria management in South Benin

Lagnika¹,

Djehoue²,

Yédomonhan³

et al. 2016

J. Med. Plants Res.

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In Bénin, malaria is a major public health concern, especially for children under five years and pregnant women. Considering the inefficiency of the health centers in some regions, people use plants for their primary health care. This study aimed to identify and document the medicinal plants used in the treatment of malaria in four departments (Littoral, Ouémé, Plateau and Zou) of south Bénin. Data were recorded using interview and field observation. 42 informants including 15 traditional healers and 27 medicinal plants sellers with an average of fourteen years of experience were interviewed. Plants were identified by a botanist from the National Herbarium of Bénin. The study revealed that a total of 34 plants species belonging to 33 genera and 24 families were collected. The most frequently cited plant species was Chamaecrista rotundifolia, Senna siamea and Dialium guineense. Caesalpinioideae and Rubiaceae are the most families mentioned by the informants. The most common preparation method is decoction and the route of administration is oral. The results contributed to the conservation of empirical knowledge of medicinal plants used for the treatment of malaria and could help to identify new research topics in connection with the implementation of Traditional Medicines.

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Section: Introductionmentioning

confidence: 99%

Ethnobotanical survey of medicinal plants used in malaria management in South Benin

Lagnika¹,

Djehoue²,

Yédomonhan³

et al. 2016

J. Med. Plants Res.

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In Vivo Antiplasmodial Activity of Entandrophragma cylindricum (Sprague) Sprague Ethyl Acetate Extract in Plasmodium berghei-Infected Mice

Nadia

Cédric

Christian

et al. 2020

Journal of Parasitology Research

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Background. One of the most dangerous Plasmodium species is Plasmodium falciparum. Hence, it causes a higher rate of mortality. The resistance of Plasmodium falciparum to the ACT (Artemisinin-based Combination Therapies) has led to the search for new antimalarial drugs. The purpose of this research was to assess the in vivo antiplasmodial activity of Entandrophragma cylindricum ethyl acetate extract to provide a scientific basis for the use of this medicinal plant to treat malaria. Methods. Entandrophragma cylindricum stem bark powder was macerated in ethyl acetate to obtain the extract. The extract liquid filtrate was concentrated, evaporated and dry using a Rotavapor. The Peter and Rane test were used for the suppressive and curative antiplasmodial activities at different doses (125, 250 and 500 mg/kg). A positive and negative control groups were administered chloroquine (5 mg/kg) and 10% hypromelose, respectively. To assess the parasitemia of the mice a thin blood smear was made. Results. The ethyl acetate extract completely (100%) inhibited the development of P. berghei in the suppressive test at the dose of 500 mg/kg while that of the curative test was inhibited at 95%. The extract-treated group (500 mg/kg) and (Chloroquine (5 mg/kg) group all survived. The negative control group recorded a 100% mortality rate. Conclusion. The present study provides scientific confirmation on the use of E. cylindricum stem bark as an antiplasmodial remedy. However, the identification of the mode of action and the purification of the active compounds are necessary for further studies.

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<i>In vitro</i> antiplasmodial properties of <i>Flacourtia flavescens</i> willd. (<i>Flacourtiaceae</i>) and <i>Rytigynia canthioides</i> (benth.) Robyns (rubiaceae)

Cited by 2 publications

References 14 publications

Ethnobotanical survey of medicinal plants used in malaria management in South Benin

Ethnobotanical survey of medicinal plants used in malaria management in South Benin

In Vivo Antiplasmodial Activity of Entandrophragma cylindricum (Sprague) Sprague Ethyl Acetate Extract in Plasmodium berghei-Infected Mice

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