&lt;i&gt;In vitro&lt;/i&gt; Comparison of the Antifungal Activities of R34,000, Miconazole and Amphotericin B

Dm, Dixon; Ge, Wagner; Shadomy, Smith; Hj, Shadomy

doi:10.1159/000237809

Cited by 19 publications

(9 citation statements)

References 7 publications

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“…One previous report on the in vitro sus ceptibilities of the dematiaceous fungi av eraged the findings for 13 strains of Cladosporium, Phialophora and Fonsecaea spe cies [19]. Only 23% of the strains were sus ceptible to ^4 ¿tg/ml of Amph B; since different species of dematiaceous fungi were tested, it is not possible to make a di rect comparison.…”

Section: Discussionmentioning

confidence: 97%

In vitro and in vivo Drug Studies with Three Agents of Central Nervous System Phaeohyphomycosis

Dixon

Polak

1987

Chemotherapy

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Amphotericin B (Amph B), 5-fluorocytosine (5-FC), ketoconazole (KTZ), fluconazole (FLZ), amorolfine (AMOR) and terbinafine (TER) were tested against 3 agents of central nervous system phaeohyphomycosis in vitro and in life-threatening infections in mice. The fungi studied were Cladosporium bantianum, Dactylaria constricta and Wangiella dermatitidis. The broadest protection against this group of fungi in mice was offered by 5-FC followed by Amph B and FLZ, then KTZ. AMOR and TER were inactive in vivo. The results of in vitro susceptibility testing had no predictive value. In contrast, the data obtained from the mouse models should be useful clinically.

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Section: Discussionmentioning

confidence: 97%

In vitro and in vivo Drug Studies with Three Agents of Central Nervous System Phaeohyphomycosis

Dixon

Polak

1987

Chemotherapy

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“…Com pounds belonging to the imidazole class o f antifungal agents have been shown to have broad spectra of antifungal activities in vitro [1,2,4,6]. Oxiconazole [Ro 13-8996; Z-2,4-dichloro-2-imidazoll-yl)-acetophenonel-0-(2,4-dichlorobenzyl)-oxime nitrate; F. H offm ann-La Roche, Basel, Switzerland; Siegfried, Zofingen, Switzerland] is a recently de scribed imidazole derivative characterized by a broad antifungal spectrum in vitro as well as in vivo activity both topically and orally [7,8].…”

Section: Introductionmentioning

confidence: 99%

In vitro Susceptibility Studies with Oxiconazole (Ro 13–8996)

Gebhart

Espinel-Ingroff

Shadomy³

1984

Chemotherapy

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Oxiconazole (Ro 13–8996) is a recently described imidazole derivative intended for topical use. 128 isolates of pathogenic fungi were tested in vitro against oxiconazole, miconazole, and ketoconazole using an agar dilution method. Results indicated that miconazole was markedly more active than either oxiconazole or ketoconazole against Candida albicans while ketoconazole was the more active compound against Candida parapsilosis. A species specific difference in the susceptibilities of isolates of Aspergillus fumigatus and Aspergillus flavus to all three imidazoles with A. flavus being more susceptible was noted. Both Mucor and Rhizopus were more susceptible to oxiconazole than to either miconazole or ketoconazole. There were no noticeable differences among the dermatophytes in tests with the three drugs with all geometric mean minimum inhibition concentrations (MIC) being less than 1.0 μgml^-1. The dematiaceous fungi also demonstrated no major differences in susceptibility to the three drugs. One isolate of Pseudallescheria boydii was relatively resistant to all three drugs (MIC ≥16 μgml^-1).

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“…One of the drug-free plates was inoculated at the beginning and the other at the end of the set. Plates were incubated at 300C for 2 May 1983). Also, it has been shown that R 51,211 has curative effects at dosages of 2.5 to 10 mg/kg in experimentally disseminated trichophytosis and systemic candidiasis (12).…”

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In vitro studies with R 51,211 (itraconazole)

Espinel-Ingroff¹,

Shadomy²,

Gebhart³

1984

Antimicrob Agents Chemother

128

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The in vitro activity of R 51,211 (itraconazole, accepted generic name; Janssen Pharmaceutica, Beerse, Belgium), a new orally active triazole, was compared with those of two existing orally active azoles, ketoconazole and BAY n 7133, and a topical agent, Ro 14-4767/002. An agar dilution procedure (Kimmig agar) was performed with 148 isolates of pathogenic fungi. Incubation was at 30 degrees C from 48 h to 7 days. R 51,211 was dissolved in 0.2 N HCl in absolute ethanol, ketoconazole was dissolved in 0.2 N HCl alone, BAY n 7133 was dissolved in absolute ethanol, and Ro 14-4767/002 was dissolved in dimethyl sulfoxide. R 51,211 and Ro 14-4767/002 were the most active drugs against isolates of Histoplasma capsulatum, and R 51,211 showed the greatest activity in vitro against isolates of Blastomyces dermatitidis and Cryptococcus neoformans. Ro 14-4767/002 was the most active drug against 30 isolates of dermatophytes, followed by R 51,211, ketoconazole, and BAY n 7133. R 51,211 showed the best activity in vitro against 19 isolates of Aspergillus fumigatus and Aspergillus flavus, as well as 19 isolates of dematiaceous fungi. All four drugs had 90% MICs of greater than or equal to 16 micrograms/ml when tested with isolates of zygomycetous fungi.

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<i>In vitro</i> Comparison of the Antifungal Activities of R34,000, Miconazole and Amphotericin B

Cited by 19 publications

References 7 publications

In vitro and in vivo Drug Studies with Three Agents of Central Nervous System Phaeohyphomycosis

In vitro and in vivo Drug Studies with Three Agents of Central Nervous System Phaeohyphomycosis

In vitro Susceptibility Studies with Oxiconazole (Ro 13–8996)

In vitro studies with R 51,211 (itraconazole)

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