In vitro susceptibilities of 78 isolates of pathogenic filamentous fungi to the imidazole compounds R34,000 and miconazole and to amphotericin B were determined using an agar dilution technique. Allescheria boydii, Sporothrix schenckii and the dematiaceous fungi (Cladosporium, Fonsecaea and Phialophora spp.) were most susceptible to miconazole with minimum inhibitory concentration (MIC) values ranging from ≤ 0.25 to 32 µg/ml and with geometric mean MIC (G-MIC) values of 0.56–1.24 µg/ml. Isolates of Aspergillus jumigatus were more susceptible to amphotericin B and miconazole than to R34,000 with G-MIC values of 1.20 and 3.48 µg/ml, respectively. Coccidioides immitis, Histoplasma capsulatum and Blastomyces dermatitidis were highly susceptible to all three drugs (G-MICs < 1 µg/ml); R34,000 was the most active of the three compounds against C. immitis (G-MIC = 0.44 µg/ml).

An unusual fungus, probably traumatically introduced into the eye of a horse while grazing, was studied on various mycological media. Upon examination of colonies the organism produced bulbils and clearly exhibited the characteristics of a new species of Papulaspora, P. equi Shadomy & Dixon.

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